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DNA
,Created page with "<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><b>Deoxyribonucleic acid</b> (<b>DNA</b>) is..."
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><b>Deoxyribonucleic acid</b> (<b>DNA</b>) is a molecule that encodes the <a href="http://en.wikipedia.org/wiki/Genetics" title="Genetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic</a> instructions used in the development and functioning of all known living <a href="http://en.wikipedia.org/wiki/Organism" title="Organism" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">organisms</a> and many <a href="http://en.wikipedia.org/wiki/Virus" title="Virus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viruses</a>. Along with <a href="http://en.wikipedia.org/wiki/RNA" title="RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA</a> and <a href="http://en.wikipedia.org/wiki/Proteins" title="Proteins" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">proteins</a>, DNA is one of the three major<a href="http://en.wikipedia.org/wiki/Macromolecules" title="Macromolecules" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">macromolecules</a> essential for all known forms of <a href="http://en.wikipedia.org/wiki/Life" title="Life" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">life</a>. Most DNA molecules are double-stranded helices, consisting of two long <a href="http://en.wikipedia.org/wiki/Biopolymer" title="Biopolymer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">biopolymers</a> of simpler units called <a href="http://en.wikipedia.org/wiki/Nucleotide" title="Nucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleotides</a>—each nucleotide is composed of a <a href="http://en.wikipedia.org/wiki/Nucleobase" title="Nucleobase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleobase</a> (<a href="http://en.wikipedia.org/wiki/Guanine" title="Guanine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">guanine</a>,<a href="http://en.wikipedia.org/wiki/Adenine" title="Adenine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenine</a>, <a href="http://en.wikipedia.org/wiki/Thymine" title="Thymine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine</a>, and <a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a>), recorded using the letters G, A, T, and C, as well as a <a href="http://en.wikipedia.org/wiki/Backbone_chain" title="Backbone chain" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">backbone</a> made of alternating<a href="http://en.wikipedia.org/wiki/Monosaccharide" title="Monosaccharide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sugars</a> (<a href="http://en.wikipedia.org/wiki/Deoxyribose" title="Deoxyribose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">deoxyribose</a>) and <a href="http://en.wikipedia.org/wiki/Phosphate" title="Phosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphate</a> groups (related to <a href="http://en.wikipedia.org/wiki/Phosphoric_acid" title="Phosphoric acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphoric acid</a>), with the nucleobases (G, A, T, C) attached to the sugars. DNA is well-suited for biological information storage, since the DNA backbone is resistant to cleavage and the double-stranded structure provides the molecule with a built-in duplicate of the encoded information.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The two strands of DNA run in opposite directions to each other and are therefore <a href="http://en.wikipedia.org/wiki/Antiparallel_(biochemistry)" title="Antiparallel (biochemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">anti-parallel</a>, one backbone being 3′ (three prime) and the other 5′ (five prime). This refers to the direction the 3rd and 5th carbon on the sugar molecule is facing. Attached to each sugar is one of four types of molecules called nucleobases (informally, <i>bases</i>). It is the<a href="http://en.wikipedia.org/wiki/Nucleic_acid_sequence" title="Nucleic acid sequence" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sequence</a> of these four nucleobases along the backbone that encodes genetic information. This information is read using the <a href="http://en.wikipedia.org/wiki/Genetic_code" title="Genetic code" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic code</a>, which specifies the sequence of the <a href="http://en.wikipedia.org/wiki/Amino_acid" title="Amino acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">amino acids</a> within proteins. The code is read by copying stretches of DNA into the related <a href="http://en.wikipedia.org/wiki/Nucleic_acid" title="Nucleic acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleic acid</a> RNA in a process called <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" title="Transcription (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription</a>.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Within cells, DNA is organized into long structures called <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomes</a>. During <a href="http://en.wikipedia.org/wiki/Cell_division" title="Cell division" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell division</a> these chromosomes are duplicated in the process of <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a>, providing each cell its own complete set of chromosomes. <a href="http://en.wikipedia.org/wiki/Eukaryote" title="Eukaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Eukaryotic organisms</a> (<a href="http://en.wikipedia.org/wiki/Animal" title="Animal" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">animals</a>, <a href="http://en.wikipedia.org/wiki/Plant" title="Plant" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">plants</a>, <a href="http://en.wikipedia.org/wiki/Fungus" title="Fungus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">fungi</a>, and <a href="http://en.wikipedia.org/wiki/Protist" title="Protist" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protists</a>) store most of their DNA inside the <a href="http://en.wikipedia.org/wiki/Cell_nucleus" title="Cell nucleus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell nucleus</a> and some of their DNA in<a href="http://en.wikipedia.org/wiki/Organelle" title="Organelle" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">organelles</a>, such as <a href="http://en.wikipedia.org/wiki/Mitochondria" title="Mitochondria" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mitochondria</a> or <a href="http://en.wikipedia.org/wiki/Chloroplasts" title="Chloroplasts" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chloroplasts</a>.<sup id="cite_ref-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[1]</a></sup> In contrast, <a href="http://en.wikipedia.org/wiki/Prokaryote" title="Prokaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">prokaryotes</a> (<a href="http://en.wikipedia.org/wiki/Bacteria" title="Bacteria" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacteria</a> and <a href="http://en.wikipedia.org/wiki/Archaea" title="Archaea" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">archaea</a>) store their DNA only in the <a href="http://en.wikipedia.org/wiki/Cytoplasm" title="Cytoplasm" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytoplasm</a>. Within the chromosomes, <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromatin</a> proteins such as <a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histones</a> compact and organize DNA. These compact structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The obsolete synonym "<b>desoxyribonucleic acid</b>" may occasionally be encountered, for example, in pre-1953 genetics.</p>
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Chemical structure of DNA. <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Hydrogen bonds</a> shown as dotted lines.</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA is a long <a href="http://en.wikipedia.org/wiki/Polymer" title="Polymer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polymer</a> made from repeating units called <a href="http://en.wikipedia.org/wiki/Nucleotide" title="Nucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleotides</a>.<sup id="cite_ref-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[2]</a></sup><sup id="cite_ref-Alberts_3-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Alberts-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[3]</a></sup><sup id="cite_ref-Butler_4-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Butler-4" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[4]</a></sup> DNA was first identified and isolated by <a href="http://en.wikipedia.org/wiki/Friedrich_Miescher" title="Friedrich Miescher" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Friedrich Miescher</a> and the double helix structure of DNA was first discovered by <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">James Watson</a> and <a href="http://en.wikipedia.org/wiki/Francis_Crick" title="Francis Crick" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Francis Crick</a>. The structure of DNA of all species comprises two helical chains each coiled round the same axis, and each with a pitch of 34 <a href="http://en.wikipedia.org/wiki/%C3%85ngstr%C3%B6m" title="Ångström" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ångströms</a> (3.4 <a href="http://en.wikipedia.org/wiki/Nanometre" title="Nanometre" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanometres</a>) and a radius of 10 ångströms (1.0 <a href="http://en.wikipedia.org/wiki/Nanometre" title="Nanometre" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanometres</a>).<sup id="cite_ref-FWPUB_5-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-FWPUB-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[5]</a></sup> According to another study, when measured in a particular solution, the DNA chain measured 22 to 26 <a href="http://en.wikipedia.org/wiki/%C3%85ngstr%C3%B6m" title="Ångström" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ångströms</a> wide (2.2 to 2.6 <a href="http://en.wikipedia.org/wiki/Nanometre" title="Nanometre" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanometres</a>), and one nucleotide unit measured 3.3 Å (0.33 nm) long.<sup id="cite_ref-6" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[6]</a></sup> Although each individual repeating unit is very small, DNA polymers can be very large molecules containing millions of nucleotides. For instance, the largest human <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosome</a>, chromosome <a href="http://en.wikipedia.org/wiki/Chromosome_1_(human)" title="Chromosome 1 (human)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">number 1</a>, consists of approximately 220 million <a href="http://en.wikipedia.org/wiki/Base_pair" title="Base pair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">base pairs</a><sup id="cite_ref-7" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[7]</a></sup> and is 85 mm long.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In living organisms DNA does not usually exist as a single molecule, but instead as a pair of molecules that are held tightly together.<sup id="cite_ref-autogenerated2_8-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-autogenerated2-8" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[8]</a></sup><sup id="cite_ref-berg_9-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-berg-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[9]</a></sup> These two long strands entwine like vines, in the shape of a <a href="http://en.wikipedia.org/wiki/Double_helix" title="Double helix" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">double helix</a>. The nucleotide repeats contain both the segment of the backbone of the molecule, which holds the chain together, and a nucleobase, which interacts with the other DNA strand in the helix. A nucleobase linked to a sugar is called a <a href="http://en.wikipedia.org/wiki/Nucleoside" title="Nucleoside" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoside</a> and a base linked to a sugar and one or more phosphate groups is called a <a href="http://en.wikipedia.org/wiki/Nucleotide" title="Nucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleotide</a>. A polymer comprising multiple linked nucleotides (as in DNA) is called a <a href="http://en.wikipedia.org/wiki/Polynucleotide" title="Polynucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polynucleotide</a>.<sup id="cite_ref-IUPAC_10-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-IUPAC-10" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[10]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The backbone of the DNA strand is made from alternating <a href="http://en.wikipedia.org/wiki/Phosphate" title="Phosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphate</a> and <a href="http://en.wikipedia.org/wiki/Carbohydrate" title="Carbohydrate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sugar</a> residues.<sup id="cite_ref-Ghosh_11-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Ghosh-11" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[11]</a></sup> The sugar in DNA is <a href="http://en.wikipedia.org/wiki/Deoxyribose" title="Deoxyribose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">2-deoxyribose</a>, which is a<a href="http://en.wikipedia.org/wiki/Pentose" title="Pentose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">pentose</a> (five-<a href="http://en.wikipedia.org/wiki/Carbon" title="Carbon" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">carbon</a>) sugar. The sugars are joined together by phosphate groups that form <a href="http://en.wikipedia.org/wiki/Phosphodiester_bond" title="Phosphodiester bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphodiester bonds</a> between the third and fifth carbon <a href="http://en.wikipedia.org/wiki/Atom" title="Atom" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">atoms</a> of adjacent sugar rings. These asymmetric <a href="http://en.wikipedia.org/wiki/Covalent_bond" title="Covalent bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bonds</a> mean a strand of DNA has a direction. In a double helix the direction of the nucleotides in one strand is opposite to their direction in the other strand: the strands are<i>antiparallel</i>. The asymmetric ends of DNA strands are called the <a href="http://en.wikipedia.org/wiki/Directionality_(molecular_biology)" title="Directionality (molecular biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5′</a> (<i>five prime</i>) and <a href="http://en.wikipedia.org/wiki/Directionality_(molecular_biology)" title="Directionality (molecular biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">3′</a> (<i>three prime</i>) ends, with the 5′ end having a terminal phosphate group and the 3′ end a terminal hydroxyl group. One major difference between DNA and RNA is the sugar, with the 2-deoxyribose in DNA being replaced by the alternative pentose sugar <a href="http://en.wikipedia.org/wiki/Ribose" title="Ribose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ribose</a> in RNA.<sup id="cite_ref-berg_9-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-berg-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[9]</a></sup></p>
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A section of DNA. The bases lie horizontally between the two spiraling strands.<sup id="cite_ref-12" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-12" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[12]</a></sup>(<a href="http://en.wikipedia.org/wiki/File:DNA_orbit_animated.gif" title="File:DNA orbit animated.gif" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">animated version</a>).</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The DNA double helix is stabilized primarily by two forces: <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen bonds</a> between nucleotides and <a href="http://en.wikipedia.org/wiki/Stacking_(chemistry)" title="Stacking (chemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">base-stacking</a> interactions among <a href="http://en.wikipedia.org/wiki/Aromatic" title="Aromatic" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aromatic</a> nucleobases.<sup id="cite_ref-Yakovchuk2006_13-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Yakovchuk2006-13" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[13]</a></sup> In the aqueous environment of the cell, the conjugated <a href="http://en.wikipedia.org/wiki/Pi_bond" title="Pi bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">π bonds</a> of nucleotide bases align perpendicular to the axis of the DNA molecule, minimizing their interaction with the <a href="http://en.wikipedia.org/wiki/Solvation_shell" title="Solvation shell" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">solvation shell</a> and therefore, the <a href="http://en.wikipedia.org/wiki/Gibbs_free_energy" title="Gibbs free energy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Gibbs free energy</a>. The four bases found in DNA are <a href="http://en.wikipedia.org/wiki/Adenine" title="Adenine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenine</a> (abbreviated A), <a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a> (C), <a href="http://en.wikipedia.org/wiki/Guanine" title="Guanine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">guanine</a> (G) and <a href="http://en.wikipedia.org/wiki/Thymine" title="Thymine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine</a> (T). These four bases are attached to the sugar/phosphate to form the complete nucleotide, as shown for <a href="http://en.wikipedia.org/wiki/Adenosine_monophosphate" title="Adenosine monophosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenosine monophosphate</a>.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Nucleobase_classification">Nucleobase classification</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The nucleobases are classified into two types: the <a href="http://en.wikipedia.org/wiki/Purine" title="Purine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">purines</a>, A and G, being fused five- and six-membered <a href="http://en.wikipedia.org/wiki/Heterocyclic_compound" title="Heterocyclic compound" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">heterocyclic compounds</a>, and the <a href="http://en.wikipedia.org/wiki/Pyrimidine" title="Pyrimidine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">pyrimidines</a>, the six-membered rings C and T.<sup id="cite_ref-berg_9-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-berg-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[9]</a></sup> A fifth pyrimidine nucleobase, <a href="http://en.wikipedia.org/wiki/Uracil" title="Uracil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">uracil</a> (U), usually takes the place of thymine in RNA and differs from thymine by lacking a <a href="http://en.wikipedia.org/wiki/Methyl_group" title="Methyl group" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methyl group</a> on its ring. In addition to RNA and DNA a large number of artificial <a href="http://en.wikipedia.org/wiki/Nucleic_acid_analogues" title="Nucleic acid analogues" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleic acid analogues</a> have also been created to study the properties of nucleic acids, or for use in biotechnology.<sup id="cite_ref-14" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-14" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[14]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Uracil is not usually found in DNA, occurring only as a breakdown product of cytosine. However in a number of bacteriophages – <i>Bacillus subtilis</i> bacteriophages PBS1 and PBS2 and <i>Yersinia</i> bacteriophage piR1-37 – thymine has been replaced by uracil.<sup id="cite_ref-Kiljunen2005_15-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Kiljunen2005-15" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[15]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Base_J" title="Base J" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Base J</a> (beta-d-glucopyranosyloxymethyluracil), a modified form of uracil, is also found in a number of organisms: the flagellates <i><a href="http://en.wikipedia.org/w/index.php?title=Diplonema_(protozoa)&action=edit&redlink=1" class="new" title="Diplonema (protozoa) (page does not exist)" style="text-decoration: none; color: rgb(165, 88, 88); background-image: none;">Diplonema</a></i> and<i><a href="http://en.wikipedia.org/wiki/Euglena" title="Euglena" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Euglena</a></i>, and all the <a href="http://en.wikipedia.org/wiki/Kinetoplastid" title="Kinetoplastid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">kinetoplastid</a> genera<sup id="cite_ref-Simpson1998_16-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Simpson1998-16" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[16]</a></sup> Biosynthesis of J occurs in two steps: in the first step a specific thymidine in DNA is converted into hydroxymethyldeoxyuridine; in the second HOMedU is glycosylated to form J.<sup id="cite_ref-Borst2008_17-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Borst2008-17" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[17]</a></sup> Proteins that bind specifically to this base have been identified.<sup id="cite_ref-Cross1999_18-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Cross1999-18" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[18]</a></sup><sup id="cite_ref-DiPaolo2005_19-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-DiPaolo2005-19" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[19]</a></sup><sup id="cite_ref-Vainio2009_20-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Vainio2009-20" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[20]</a></sup> These proteins appear to be distant relatives of the Tet1 oncogene that is involved in the pathogenesis of <a href="http://en.wikipedia.org/wiki/Acute_myeloid_leukemia" title="Acute myeloid leukemia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">acute myeloid leukemia</a>.<sup id="cite_ref-Iyer2009_21-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Iyer2009-21" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[21]</a></sup> J appears to act as a termination signal for <a href="http://en.wikipedia.org/wiki/RNA_polymerase_II" title="RNA polymerase II" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase II</a>.<sup id="cite_ref-van_Luenen2012_22-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-van_Luenen2012-22" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[22]</a></sup><sup id="cite_ref-Hazelbaker2012_23-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Hazelbaker2012-23" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[23]</a></sup></p>
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Major and minor grooves of DNA. Minor groove is a binding site for the dye <a href="http://en.wikipedia.org/wiki/Hoechst_stain" title="Hoechst stain" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Hoechst 33258</a>.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Grooves">Grooves</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Twin helical strands form the DNA backbone. Another double helix may be found tracing the spaces, or grooves, between the strands. These voids are adjacent to the base pairs and may provide a <a href="http://en.wikipedia.org/wiki/Binding_site" title="Binding site" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">binding site</a>. As the strands are not symmetrically located with respect to each other, the grooves are unequally sized. One groove, the major groove, is 22 Å wide and the other, the minor groove, is 12 Å wide.<sup id="cite_ref-24" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-24" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[24]</a></sup> The narrowness of the minor groove means that the edges of the bases are more accessible in the major groove. As a result, proteins like <a href="http://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription factors</a> that can bind to specific sequences in double-stranded DNA usually make contacts to the sides of the bases exposed in the major groove.<sup id="cite_ref-Pabo1984_25-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Pabo1984-25" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[25]</a></sup> This situation varies in unusual conformations of DNA within the cell <i>(see below)</i>, but the major and minor grooves are always named to reflect the differences in size that would be seen if the DNA is twisted back into the ordinary B form.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Base_pairing">Base pairing</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Base_pair" title="Base pair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Base pair</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In a DNA double helix, each type of nucleobase on one strand bonds with just one type of nucleobase on the other strand. This is called complementary <a href="http://en.wikipedia.org/wiki/Base_pair" title="Base pair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">base pairing</a>. Here, purines form <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen bonds</a> to pyrimidines, with adenine bonding only to thymine in two hydrogen bonds, and cytosine bonding only to guanine in three hydrogen bonds. This arrangement of two nucleotides binding together across the double helix is called a base pair. As hydrogen bonds are not <a href="http://en.wikipedia.org/wiki/Covalent_bond" title="Covalent bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">covalent</a>, they can be broken and rejoined relatively easily. The two strands of DNA in a double helix can therefore be pulled apart like a zipper, either by a mechanical force or high <a href="http://en.wikipedia.org/wiki/Temperature" title="Temperature" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">temperature</a>.<sup id="cite_ref-26" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-26" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[26]</a></sup> As a result of this complementarity, all the information in the double-stranded sequence of a DNA helix is duplicated on each strand, which is vital in DNA replication. Indeed, this reversible and specific interaction between complementary base pairs is critical for all the functions of DNA in living organisms.<sup id="cite_ref-Alberts_3-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Alberts-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[3]</a></sup></p>
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<td><a href="http://en.wikipedia.org/wiki/File:GC_DNA_base_pair.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="GC DNA base pair.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GC_DNA_base_pair.svg/282px-GC_DNA_base_pair.svg.png" width="282" height="177" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GC_DNA_base_pair.svg/423px-GC_DNA_base_pair.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GC_DNA_base_pair.svg/564px-GC_DNA_base_pair.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<td><a href="http://en.wikipedia.org/wiki/File:AT_DNA_base_pair.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="AT DNA base pair.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/9/91/AT_DNA_base_pair.svg/282px-AT_DNA_base_pair.svg.png" width="282" height="151" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/AT_DNA_base_pair.svg/423px-AT_DNA_base_pair.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/91/AT_DNA_base_pair.svg/564px-AT_DNA_base_pair.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; font-size: 12px; padding: 3px !important;">Top, a <b>GC</b> base pair with three <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen bonds</a>. Bottom, an <b>AT</b> base pair with two hydrogen bonds. Non-covalent hydrogen bonds between the pairs are shown as dashed lines.</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The two types of base pairs form different numbers of hydrogen bonds, AT forming two hydrogen bonds, and GC forming three hydrogen bonds (see figures, right). DNA with high <a href="http://en.wikipedia.org/wiki/GC-content" title="GC-content" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">GC-content</a> is more stable than DNA with low GC-content.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">As noted above, most DNA molecules are actually two polymer strands, bound together in a helical fashion by noncovalent bonds; this double stranded structure (<b>dsDNA</b>) is maintained largely by the intrastrand base stacking interactions, which are strongest for G,C stacks. The two strands can come apart – a process known as melting – to form two single-stranded DNA molecules (<b>ssDNA</b>) molecules. Melting occurs at high temperature, low salt and high pH (low pH also melts DNA, but since DNA is unstable due to acid depurination, low pH is rarely used).</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The stability of the dsDNA form depends not only on the GC-content (% G,C basepairs) but also on sequence (since stacking is sequence specific) and also length (longer molecules are more stable). The stability can be measured in various ways; a common way is the "melting temperature", which is the temperature at which 50% of the ds molecules are converted to ss molecules; melting temperature is dependent on ionic strength and the concentration of DNA. As a result, it is both the percentage of GC base pairs and the overall length of a DNA double helix that determines the strength of the association between the two strands of DNA. Long DNA helices with a high GC-content have stronger-interacting strands, while short helices with high AT content have weaker-interacting strands.<sup id="cite_ref-27" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-27" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[27]</a></sup> In biology, parts of the DNA double helix that need to separate easily, such as the TATAAT <a href="http://en.wikipedia.org/wiki/Pribnow_box" title="Pribnow box" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Pribnow box</a> in some <a href="http://en.wikipedia.org/wiki/Promoter_(biology)" title="Promoter (biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">promoters</a>, tend to have a high AT content, making the strands easier to pull apart.<sup id="cite_ref-28" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-28" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[28]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In the laboratory, the strength of this interaction can be measured by finding the temperature necessary to break the hydrogen bonds, their <a href="http://en.wikipedia.org/wiki/DNA_melting" title="DNA melting" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">melting temperature</a> (also called <i>T<sub style="line-height: 1em;">m</sub></i> value). When all the base pairs in a DNA double helix melt, the strands separate and exist in solution as two entirely independent molecules. These single-stranded DNA molecules (<i>ssDNA</i>) have no single common shape, but some conformations are more stable than others.<sup id="cite_ref-29" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-29" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[29]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Sense_and_antisense">Sense and antisense</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Sense_(molecular_biology)" title="Sense (molecular biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Sense (molecular biology)</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A DNA sequence is called "sense" if its sequence is the same as that of a <a href="http://en.wikipedia.org/wiki/Messenger_RNA" title="Messenger RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">messenger RNA</a> copy that is translated into protein.<sup id="cite_ref-30" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-30" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[30]</a></sup> The sequence on the opposite strand is called the "antisense" sequence. Both sense and antisense sequences can exist on different parts of the same strand of DNA (i.e. both strands contain both sense and antisense sequences). In both prokaryotes and eukaryotes, antisense RNA sequences are produced, but the functions of these RNAs are not entirely clear.<sup id="cite_ref-31" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-31" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[31]</a></sup> One proposal is that antisense RNAs are involved in regulating <a href="http://en.wikipedia.org/wiki/Gene_expression" title="Gene expression" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene expression</a> through RNA-RNA base pairing.<sup id="cite_ref-32" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-32" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[32]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A few DNA sequences in prokaryotes and eukaryotes, and more in <a href="http://en.wikipedia.org/wiki/Plasmid" title="Plasmid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">plasmids</a> and <a href="http://en.wikipedia.org/wiki/Virus" title="Virus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viruses</a>, blur the distinction between sense and antisense strands by having <a href="http://en.wikipedia.org/wiki/Overlapping_gene" title="Overlapping gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">overlapping genes</a>.<sup id="cite_ref-33" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-33" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[33]</a></sup> In these cases, some DNA sequences do double duty, encoding one protein when read along one strand, and a second protein when read in the opposite direction along the other strand. In <a href="http://en.wikipedia.org/wiki/Bacteria" title="Bacteria" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacteria</a>, this overlap may be involved in the regulation of gene transcription,<sup id="cite_ref-34" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-34" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[34]</a></sup> while in viruses, overlapping genes increase the amount of information that can be encoded within the small viral genome.<sup id="cite_ref-35" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-35" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[35]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Supercoiling">Supercoiling</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_supercoil" title="DNA supercoil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA supercoil</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA can be twisted like a rope in a process called <a href="http://en.wikipedia.org/wiki/DNA_supercoil" title="DNA supercoil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA supercoiling</a>. With DNA in its "relaxed" state, a strand usually circles the axis of the double helix once every 10.4 base pairs, but if the DNA is twisted the strands become more tightly or more loosely wound.<sup id="cite_ref-36" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-36" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[36]</a></sup> If the DNA is twisted in the direction of the helix, this is positive supercoiling, and the bases are held more tightly together. If they are twisted in the opposite direction, this is negative supercoiling, and the bases come apart more easily. In nature, most DNA has slight negative supercoiling that is introduced by <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> called <a href="http://en.wikipedia.org/wiki/Topoisomerase" title="Topoisomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">topoisomerases</a>.<sup id="cite_ref-Champoux_37-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Champoux-37" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[37]</a></sup> These enzymes are also needed to relieve the twisting stresses introduced into DNA strands during processes such as <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" title="Transcription (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription</a> and <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a>.<sup id="cite_ref-Wang_38-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Wang-38" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[38]</a></sup></p>
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<div class="magnify" style="margin-left: 3px; float: right; border: none !important; background-image: none !important;"><a href="http://en.wikipedia.org/wiki/File:A-DNA,_B-DNA_and_Z-DNA.png" class="internal" title="Enlarge" style="text-decoration: none; color: rgb(11, 0, 128); display: block; background-image: none !important; border: none !important;"><img src="http://bits.wikimedia.org/static-1.22wmf12/skins/common/images/magnify-clip.png" width="15" height="11" alt="" style="vertical-align: middle; display: block; border: none !important; background-image: none !important;" /></a></div>
From left to right, the structures of A, B and Z DNA</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Alternate_DNA_structures">Alternate DNA structures</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Molecular_Structure_of_Nucleic_Acids:_A_Structure_for_Deoxyribose_Nucleic_Acid" title="Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid</a>, <a href="http://en.wikipedia.org/wiki/Molecular_models_of_DNA" title="Molecular models of DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular models of DNA</a>, and<a href="http://en.wikipedia.org/wiki/DNA_structure" title="DNA structure" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA structure</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA exists in many possible <a href="http://en.wikipedia.org/wiki/Conformational_isomerism" title="Conformational isomerism" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">conformations</a> that include <a href="http://en.wikipedia.org/wiki/A-DNA" title="A-DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">A-DNA</a>, B-DNA, and <a href="http://en.wikipedia.org/wiki/Z-DNA" title="Z-DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Z-DNA</a> forms, although, only B-DNA and Z-DNA have been directly observed in functional organisms.<sup id="cite_ref-Ghosh_11-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Ghosh-11" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[11]</a></sup> The conformation that DNA adopts depends on the hydration level, DNA sequence, the amount and direction of supercoiling, chemical modifications of the bases, the type and concentration of metal <a href="http://en.wikipedia.org/wiki/Ion" title="Ion" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ions</a>, as well as the presence of<a href="http://en.wikipedia.org/wiki/Polyamine" title="Polyamine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polyamines</a> in solution.<sup id="cite_ref-39" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-39" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[39]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The first published reports of A-DNA <a href="http://en.wikipedia.org/wiki/X-ray_scattering_techniques" title="X-ray scattering techniques" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-ray diffraction patterns</a> — and also B-DNA — used analyses based on <a href="http://en.wikipedia.org/wiki/Patterson_function" title="Patterson function" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Patterson transforms</a> that provided only a limited amount of structural information for oriented fibers of DNA.<sup id="cite_ref-40" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-40" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[40]</a></sup><sup id="cite_ref-NatFranGos_41-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatFranGos-41" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[41]</a></sup> An alternate analysis was then proposed by Wilkins<i>et al.</i>, in 1953, for the <i>in vivo</i> B-DNA X-ray diffraction/scattering patterns of highly hydrated DNA fibers in terms of squares of <a href="http://en.wikipedia.org/wiki/Bessel_function" title="Bessel function" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bessel functions</a>.<sup id="cite_ref-NatWilk_42-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatWilk-42" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[42]</a></sup> In the same journal, <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">James Watson</a> and <a href="http://en.wikipedia.org/wiki/Francis_Crick" title="Francis Crick" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Francis Crick</a> presented their <a href="http://en.wikipedia.org/wiki/Molecular_models_of_DNA" title="Molecular models of DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular modeling</a> analysis of the DNA X-ray diffraction patterns to suggest that the structure was a double-helix.<sup id="cite_ref-FWPUB_5-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-FWPUB-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[5]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Although the "B-DNA form" is most common under the conditions found in cells,<sup id="cite_ref-43" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-43" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[43]</a></sup> it is not a well-defined conformation but a family of related DNA conformations<sup id="cite_ref-44" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-44" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[44]</a></sup> that occur at the high hydration levels present in living cells. Their corresponding X-ray diffraction and scattering patterns are characteristic of molecular <a href="http://en.wikipedia.org/wiki/Paracrystalline" title="Paracrystalline" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">paracrystals</a> with a significant degree of disorder.<sup id="cite_ref-45" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-45" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[45]</a></sup><sup id="cite_ref-46" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-46" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[46]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Compared to B-DNA, the A-DNA form is a wider right-handed spiral, with a shallow, wide minor groove and a narrower, deeper major groove. The A form occurs under non-physiological conditions in partially dehydrated samples of DNA, while in the cell it may be produced in hybrid pairings of DNA and RNA strands, as well as in enzyme-DNA complexes.<sup id="cite_ref-47" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-47" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[47]</a></sup><sup id="cite_ref-48" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-48" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[48]</a></sup>Segments of DNA where the bases have been chemically modified by <a href="http://en.wikipedia.org/wiki/Methylation" title="Methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methylation</a> may undergo a larger change in conformation and adopt the <a href="http://en.wikipedia.org/wiki/Z-DNA" title="Z-DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Z form</a>. Here, the strands turn about the helical axis in a <a href="http://en.wikipedia.org/wiki/Left-handed" title="Left-handed" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">left-handed</a> spiral, the opposite of the more common B form.<sup id="cite_ref-49" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-49" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[49]</a></sup> These unusual structures can be recognized by specific Z-DNA binding proteins and may be involved in the regulation of transcription.<sup id="cite_ref-50" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-50" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[50]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Alternate_DNA_chemistry">Alternate DNA chemistry</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">For a number of years exobiologists have proposed the existence of a <a href="http://en.wikipedia.org/wiki/Shadow_biosphere" title="Shadow biosphere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">shadow biosphere</a>, a postulated microbial biosphere of Earth that uses radically different biochemical and molecular processes than currently known life. One of the proposals was the existence of lifeforms that use <a href="http://en.wikipedia.org/wiki/Arsenic_DNA" title="Arsenic DNA" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">arsenic instead of phosphorus in DNA</a>. A report in 2010 of the possibility in the <a href="http://en.wikipedia.org/wiki/Bacterium" title="Bacterium" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacterium</a> <a href="http://en.wikipedia.org/wiki/GFAJ-1" title="GFAJ-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">GFAJ-1</a>, was announced,<sup id="cite_ref-arsenic_extremophile_51-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-arsenic_extremophile-51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[51]</a></sup><sup id="cite_ref-arsenic_extremophile_51-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-arsenic_extremophile-51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[51]</a></sup><sup id="cite_ref-Space_52-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Space-52" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[52]</a></sup> though the research was disputed,<sup id="cite_ref-Space_52-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Space-52" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[52]</a></sup><sup id="cite_ref-53" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-53" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[53]</a></sup> and evidence suggests the bacterium actively prevents the incorporation of arsenic into the DNA backbone and other biomolecules.<sup id="cite_ref-Nature_54-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nature-54" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[54]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Quadruplex_structures">Quadruplex structures</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/G-quadruplex" title="G-quadruplex" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">G-quadruplex</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">At the ends of the linear chromosomes are specialized regions of DNA called <a href="http://en.wikipedia.org/wiki/Telomere" title="Telomere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomeres</a>. The main function of these regions is to allow the cell to replicate chromosome ends using the enzyme <a href="http://en.wikipedia.org/wiki/Telomerase" title="Telomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomerase</a>, as the enzymes that normally replicate DNA cannot copy the extreme 3′ ends of chromosomes.<sup id="cite_ref-Greider_55-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Greider-55" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[55]</a></sup> These specialized chromosome caps also help protect the DNA ends, and stop the <a href="http://en.wikipedia.org/wiki/DNA_repair" title="DNA repair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA repair</a> systems in the cell from treating them as damage to be corrected.<sup id="cite_ref-Nugent_56-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nugent-56" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[56]</a></sup> In <a href="http://en.wikipedia.org/wiki/List_of_distinct_cell_types_in_the_adult_human_body" title="List of distinct cell types in the adult human body" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">human cells</a>, telomeres are usually lengths of single-stranded DNA containing several thousand repeats of a simple TTAGGG sequence.<sup id="cite_ref-57" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-57" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[57]</a></sup></p>
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DNA quadruplex formed by <a href="http://en.wikipedia.org/wiki/Telomere" title="Telomere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomere</a>repeats. The looped conformation of the DNA backbone is very different from the typical DNA helix.<sup id="cite_ref-58" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-58" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[58]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">These guanine-rich sequences may stabilize chromosome ends by forming structures of stacked sets of four-base units, rather than the usual base pairs found in other DNA molecules. Here, four guanine bases form a flat plate and these flat four-base units then stack on top of each other, to form a stable <a href="http://en.wikipedia.org/wiki/G-quadruplex" title="G-quadruplex" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">G-quadruplex</a> structure.<sup id="cite_ref-Burge_59-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Burge-59" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[59]</a></sup> These structures are stabilized by hydrogen bonding between the edges of the bases and <a href="http://en.wikipedia.org/wiki/Chelation" title="Chelation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chelation</a> of a metal ion in the centre of each four-base unit.<sup id="cite_ref-60" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-60" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[60]</a></sup> Other structures can also be formed, with the central set of four bases coming from either a single strand folded around the bases, or several different parallel strands, each contributing one base to the central structure.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In addition to these stacked structures, telomeres also form large loop structures called telomere loops, or T-loops. Here, the single-stranded DNA curls around in a long circle stabilized by telomere-binding proteins.<sup id="cite_ref-61" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-61" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[61]</a></sup> At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere strand disrupting the double-helical DNA and base pairing to one of the two strands. This <a href="http://en.wikipedia.org/wiki/Triple-stranded_DNA" title="Triple-stranded DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">triple-stranded</a> structure is called a displacement loop or <a href="http://en.wikipedia.org/wiki/D-loop" title="D-loop" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">D-loop</a>.<sup id="cite_ref-Burge_59-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Burge-59" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[59]</a></sup></p>
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<td><a href="http://en.wikipedia.org/wiki/File:Branch-dna-single.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Branch-dna-single.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/5/54/Branch-dna-single.svg/95px-Branch-dna-single.svg.png" width="95" height="71" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Branch-dna-single.svg/143px-Branch-dna-single.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Branch-dna-single.svg/190px-Branch-dna-single.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td><a href="http://en.wikipedia.org/wiki/File:Branch-DNA-multiple.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Branch-DNA-multiple.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Branch-DNA-multiple.svg/95px-Branch-DNA-multiple.svg.png" width="95" height="71" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Branch-DNA-multiple.svg/143px-Branch-DNA-multiple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Branch-DNA-multiple.svg/190px-Branch-DNA-multiple.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<td align="center">Single branch</td>
<td align="center">Multiple branches</td>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; padding: 3px !important;"><a href="http://en.wikipedia.org/wiki/Branched_DNA" title="Branched DNA" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Branched DNA</a> can form networks containing multiple branches.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Branched_DNA">Branched DNA</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Branched_DNA" title="Branched DNA" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Branched DNA</a> and <a href="http://en.wikipedia.org/wiki/DNA_nanotechnology" title="DNA nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA nanotechnology</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In DNA <a href="http://en.wikipedia.org/wiki/DNA_end#Frayed_ends" title="DNA end" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">fraying</a> occurs when non-complementary regions exist at the end of an otherwise complementary double-strand of DNA. However, branched DNA can occur if a third strand of DNA is introduced and contains adjoining regions able to hybridize with the frayed regions of the pre-existing double-strand. Although the simplest example of branched DNA involves only three strands of DNA, complexes involving additional strands and multiple branches are also possible.<sup id="cite_ref-62" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-62" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[62]</a></sup> Branched DNA can be used in <a href="http://en.wikipedia.org/wiki/Nanotechnology" title="Nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanotechnology</a> to construct geometric shapes, see the section on <a href="http://en.wikipedia.org/wiki/DNA#Uses_in_technology" title="DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">uses in technology</a> below.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Vibration">Vibration</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA may carry out <a href="http://en.wikipedia.org/wiki/Low-frequency_collective_motion_in_proteins_and_DNA" title="Low-frequency collective motion in proteins and DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">low-frequency</a> collective motion as observed by the <a href="http://en.wikipedia.org/wiki/Raman_spectroscopy" title="Raman spectroscopy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Raman spectroscopy</a><sup id="cite_ref-pmid7115900_63-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-pmid7115900-63" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[63]</a></sup><sup id="cite_ref-Urabe_1983_64-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Urabe_1983-64" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[64]</a></sup> and analyzed with a quasi-continuum model.<sup id="cite_ref-pmid6466317_65-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-pmid6466317-65" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[65]</a></sup><sup id="cite_ref-pmid2775828_66-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-pmid2775828-66" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[66]</a></sup></p>
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<td><a href="http://en.wikipedia.org/wiki/File:Cytosin.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Cytosin.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Cytosin.svg/75px-Cytosin.svg.png" width="75" height="102" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Cytosin.svg/113px-Cytosin.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Cytosin.svg/150px-Cytosin.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td><a href="http://en.wikipedia.org/wiki/File:5-Methylcytosine.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="5-Methylcytosine.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/3/3a/5-Methylcytosine.svg/95px-5-Methylcytosine.svg.png" width="95" height="83" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3a/5-Methylcytosine.svg/143px-5-Methylcytosine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3a/5-Methylcytosine.svg/190px-5-Methylcytosine.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td><a href="http://en.wikipedia.org/wiki/File:Thymin.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Thymin.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/1/15/Thymin.svg/97px-Thymin.svg.png" width="97" height="83" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Thymin.svg/146px-Thymin.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/15/Thymin.svg/194px-Thymin.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<td align="center"><a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a></td>
<td align="center"><a href="http://en.wikipedia.org/wiki/5-Methylcytosine" title="5-Methylcytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5-methylcytosine</a></td>
<td align="center"><a href="http://en.wikipedia.org/wiki/Thymine" title="Thymine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine</a></td>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; padding: 3px !important;">Structure of cytosine with and without the 5-methyl group. <a href="http://en.wikipedia.org/wiki/Deamination" title="Deamination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Deamination</a> converts 5-methylcytosine into thymine.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Base_modifications_and_DNA_packaging">Base modifications and DNA packaging</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_methylation" title="DNA methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA methylation</a>, <a href="http://en.wikipedia.org/wiki/Chromatin_remodeling" title="Chromatin remodeling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromatin remodeling</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The expression of genes is influenced by how the DNA is packaged in chromosomes, in a structure called <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromatin</a>. Base modifications can be involved in packaging, with regions that have low or no gene expression usually containing high levels of<a href="http://en.wikipedia.org/wiki/Methylation" title="Methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methylation</a> of <a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a> bases. DNA packaging and its influence on gene expression can also occur by covalent modifications of the <a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histone</a> protein core around which DNA is wrapped in the chromatin structure or else by remodeling carried out by chromatin remodeling complexes (see <a href="http://en.wikipedia.org/wiki/Chromatin_remodeling" title="Chromatin remodeling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromatin remodeling</a>). There is, further, <a href="http://en.wikipedia.org/wiki/Crosstalk_(biology)" title="Crosstalk (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">crosstalk</a> between DNA methylation and histone modification, so they can coordinately affect chromatin and gene expression.<sup id="cite_ref-67" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-67" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[67]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">For one example, cytosine methylation, produces <a href="http://en.wikipedia.org/wiki/5-Methylcytosine" title="5-Methylcytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5-methylcytosine</a>, which is important for <a href="http://en.wikipedia.org/wiki/X-inactivation" title="X-inactivation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-chromosome inactivation</a>.<sup id="cite_ref-68" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-68" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[68]</a></sup> The average level of methylation varies between organisms – the worm <i><a href="http://en.wikipedia.org/wiki/Caenorhabditis_elegans" title="Caenorhabditis elegans" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Caenorhabditis elegans</a></i> lacks cytosine methylation, while <a href="http://en.wikipedia.org/wiki/Vertebrate" title="Vertebrate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">vertebrates</a> have higher levels, with up to 1% of their DNA containing 5-methylcytosine.<sup id="cite_ref-69" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-69" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[69]</a></sup> Despite the importance of 5-methylcytosine, it can <a href="http://en.wikipedia.org/wiki/Deamination" title="Deamination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">deaminate</a> to leave a thymine base, so methylated cytosines are particularly prone to<a href="http://en.wikipedia.org/wiki/Mutation" title="Mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutations</a>.<sup id="cite_ref-70" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-70" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[70]</a></sup> Other base modifications include adenine methylation in bacteria, the presence of <a href="http://en.wikipedia.org/wiki/5-hydroxymethylcytosine" title="5-hydroxymethylcytosine" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5-hydroxymethylcytosine</a> in the <a href="http://en.wikipedia.org/wiki/Brain" title="Brain" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">brain</a>,<sup id="cite_ref-71" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-71" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[71]</a></sup> and the <a href="http://en.wikipedia.org/wiki/Glycosylation" title="Glycosylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">glycosylation</a> of uracil to produce the "J-base" in <a href="http://en.wikipedia.org/wiki/Kinetoplastid" title="Kinetoplastid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">kinetoplastids</a>.<sup id="cite_ref-72" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-72" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[72]</a></sup><sup id="cite_ref-73" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-73" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[73]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Damage">Damage</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_damage_(naturally_occurring)" title="DNA damage (naturally occurring)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA damage (naturally occurring)</a>, <a href="http://en.wikipedia.org/wiki/Mutation" title="Mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Mutation</a>, <a href="http://en.wikipedia.org/wiki/DNA_damage_theory_of_aging" title="DNA damage theory of aging" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA damage theory of aging</a></div>
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A <a href="http://en.wikipedia.org/wiki/Covalent" title="Covalent" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">covalent</a> <a href="http://en.wikipedia.org/wiki/Adduct" title="Adduct" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adduct</a> between a<a href="http://en.wikipedia.org/wiki/Cytochrome_P450,_family_1,_member_A1" title="Cytochrome P450, family 1, member A1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">metabolically activated</a> form of<a href="http://en.wikipedia.org/wiki/Benzo(a)pyrene" title="Benzo(a)pyrene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">benzo[<i>a</i>]pyrene</a>, the major <a href="http://en.wikipedia.org/wiki/Mutagen" title="Mutagen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutagen</a> in<a href="http://en.wikipedia.org/wiki/Tobacco_smoking" title="Tobacco smoking" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">tobacco smoke</a>, and DNA<sup id="cite_ref-74" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-74" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[74]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA can be damaged by many sorts of <a href="http://en.wikipedia.org/wiki/Mutagen" title="Mutagen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutagens</a>, which change the DNA sequence. Mutagens include <a href="http://en.wikipedia.org/wiki/Oxidizing_agent" title="Oxidizing agent" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">oxidizing agents</a>, <a href="http://en.wikipedia.org/wiki/Alkylation" title="Alkylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">alkylating agents</a>and also high-energy <a href="http://en.wikipedia.org/wiki/Electromagnetic_radiation" title="Electromagnetic radiation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">electromagnetic radiation</a> such as <a href="http://en.wikipedia.org/wiki/Ultraviolet" title="Ultraviolet" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ultraviolet</a> light and <a href="http://en.wikipedia.org/wiki/X-ray" title="X-ray" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-rays</a>. The type of DNA damage produced depends on the type of mutagen. For example, UV light can damage DNA by producing <a href="http://en.wikipedia.org/wiki/Thymine_dimer" title="Thymine dimer" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine dimers</a>, which are cross-links between pyrimidine bases.<sup id="cite_ref-75" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-75" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[75]</a></sup> On the other hand, oxidants such as <a href="http://en.wikipedia.org/wiki/Radical_(chemistry)" title="Radical (chemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">free radicals</a> or <a href="http://en.wikipedia.org/wiki/Hydrogen_peroxide" title="Hydrogen peroxide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen peroxide</a> produce multiple forms of damage, including base modifications, particularly of guanosine, and double-strand breaks.<sup id="cite_ref-76" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-76" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[76]</a></sup> A typical human cell contains about 150,000 bases that have suffered oxidative damage.<sup id="cite_ref-77" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-77" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[77]</a></sup> Of these oxidative lesions, the most dangerous are double-strand breaks, as these are difficult to repair and can produce <a href="http://en.wikipedia.org/wiki/Point_mutation" title="Point mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">point mutations</a>, <a href="http://en.wikipedia.org/wiki/Genetic_insertion" title="Genetic insertion" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">insertions</a> and <a href="http://en.wikipedia.org/wiki/Deletion_(genetics)" title="Deletion (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">deletions</a> from the DNA sequence, as well as <a href="http://en.wikipedia.org/wiki/Chromosomal_translocation" title="Chromosomal translocation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomal translocations</a>.<sup id="cite_ref-78" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-78" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[78]</a></sup> These mutations can cause<a href="http://en.wikipedia.org/wiki/Cancer" title="Cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cancer</a>. Because of inherent limitations in the DNA repair mechanisms, if humans lived long enough, they would all eventually develop cancer.<sup id="cite_ref-Weinberg_79-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Weinberg-79" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[79]</a></sup><sup id="cite_ref-80" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-80" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[80]</a></sup> DNA damages that are <a href="http://en.wikipedia.org/wiki/DNA_damage_(naturally_occurring)" title="DNA damage (naturally occurring)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">naturally occurring</a>, due to normal cellular processes that produce reactive oxygen species, the hydrolytic activities of cellular water, etc., also occur frequently. Although most of these damages are repaired, in any cell some DNA damage may remain despite the action of repair processes. These remaining DNA damages accumulate with age in mammalian postmitotic tissues. This accumulation appears to be an important underlying cause of aging.<sup id="cite_ref-81" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-81" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[81]</a></sup><sup id="cite_ref-82" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-82" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[82]</a></sup><sup id="cite_ref-83" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-83" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[83]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Many mutagens fit into the space between two adjacent base pairs, this is called <i><a href="http://en.wikipedia.org/wiki/Intercalation_(chemistry)" title="Intercalation (chemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">intercalation</a></i>. Most intercalators are <a href="http://en.wikipedia.org/wiki/Aromaticity" title="Aromaticity" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aromatic</a> and planar molecules; examples include <a href="http://en.wikipedia.org/wiki/Ethidium_bromide" title="Ethidium bromide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ethidium bromide</a>, <a href="http://en.wikipedia.org/wiki/Acridine" title="Acridine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">acridines</a>, <a href="http://en.wikipedia.org/wiki/Daunorubicin" title="Daunorubicin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">daunomycin</a>, and <a href="http://en.wikipedia.org/wiki/Doxorubicin" title="Doxorubicin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doxorubicin</a>. For an intercalator to fit between base pairs, the bases must separate, distorting the DNA strands by unwinding of the double helix. This inhibits both transcription and DNA replication, causing toxicity and mutations.<sup id="cite_ref-84" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-84" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[84]</a></sup> As a result, DNA intercalators may be <a href="http://en.wikipedia.org/wiki/Carcinogen" title="Carcinogen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">carcinogens</a>, and in the case of thalidomide, a <a href="http://en.wikipedia.org/wiki/Teratogen" title="Teratogen" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">teratogen</a>.<sup id="cite_ref-85" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-85" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[85]</a></sup>Others such as <a href="http://en.wikipedia.org/wiki/Benzo(a)pyrene" title="Benzo(a)pyrene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">benzo[<i>a</i>]pyrene diol epoxide</a> and <a href="http://en.wikipedia.org/wiki/Aflatoxin" title="Aflatoxin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aflatoxin</a> form DNA adducts that induce errors in replication.<sup id="cite_ref-86" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-86" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[86]</a></sup> Nevertheless, due to their ability to inhibit DNA transcription and replication, other similar toxins are also used in <a href="http://en.wikipedia.org/wiki/Chemotherapy" title="Chemotherapy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chemotherapy</a> to inhibit rapidly growing <a href="http://en.wikipedia.org/wiki/Cancer" title="Cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cancer</a> cells.<sup id="cite_ref-87" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-87" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[87]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Biological_functions">Biological functions</span></h2>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA usually occurs as linear <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomes</a> in <a href="http://en.wikipedia.org/wiki/Eukaryote" title="Eukaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">eukaryotes</a>, and circular chromosomes in <a href="http://en.wikipedia.org/wiki/Prokaryote" title="Prokaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">prokaryotes</a>. The set of chromosomes in a cell makes up its <a href="http://en.wikipedia.org/wiki/Genome" title="Genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genome</a>; the <a href="http://en.wikipedia.org/wiki/Human_genome" title="Human genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">human genome</a> has approximately 3 billion base pairs of DNA arranged into 46 chromosomes.<sup id="cite_ref-88" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-88" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[88]</a></sup> The information carried by DNA is held in the <a href="http://en.wikipedia.org/wiki/DNA_sequence" title="DNA sequence" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sequence</a> of pieces of DNA called <a href="http://en.wikipedia.org/wiki/Gene" title="Gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genes</a>. <a href="http://en.wikipedia.org/wiki/Transmission_(genetics)" title="Transmission (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Transmission</a> of genetic information in genes is achieved via complementary base pairing. For example, in transcription, when a cell uses the information in a gene, the DNA sequence is copied into a complementary RNA sequence through the attraction between the DNA and the correct RNA nucleotides. Usually, this RNA copy is then used to make a matching <a href="http://en.wikipedia.org/wiki/Peptide_sequence" title="Peptide sequence" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein sequence</a> in a process called <a href="http://en.wikipedia.org/wiki/Translation_(biology)" title="Translation (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">translation</a>, which depends on the same interaction between RNA nucleotides. In alternative fashion, a cell may simply copy its genetic information in a process called DNA replication. The details of these functions are covered in other articles; here we focus on the interactions between DNA and other molecules that mediate the function of the genome.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Genes_and_genomes">Genes and genomes</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Cell_nucleus" title="Cell nucleus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Cell nucleus</a>, <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromatin</a>, <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromosome</a>, <a href="http://en.wikipedia.org/wiki/Gene" title="Gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Gene</a>, <a href="http://en.wikipedia.org/wiki/Noncoding_DNA" title="Noncoding DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Noncoding DNA</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Genomic DNA is tightly and orderly packed in the process called <a href="http://en.wikipedia.org/wiki/DNA_condensation" title="DNA condensation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA condensation</a> to fit the small available volumes of the cell. In eukaryotes, DNA is located in the <a href="http://en.wikipedia.org/wiki/Cell_nucleus" title="Cell nucleus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell nucleus</a>, as well as small amounts in <a href="http://en.wikipedia.org/wiki/Mitochondrion" title="Mitochondrion" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mitochondria</a> and <a href="http://en.wikipedia.org/wiki/Chloroplast" title="Chloroplast" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chloroplasts</a>. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the <a href="http://en.wikipedia.org/wiki/Nucleoid" title="Nucleoid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoid</a>.<sup id="cite_ref-89" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-89" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[89]</a></sup> The genetic information in a genome is held within genes, and the complete set of this information in an organism is called its <a href="http://en.wikipedia.org/wiki/Genotype" title="Genotype" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genotype</a>. A gene is a unit of <a href="http://en.wikipedia.org/wiki/Heredity" title="Heredity" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">heredity</a> and is a region of DNA that influences a particular characteristic in an organism. Genes contain an <a href="http://en.wikipedia.org/wiki/Open_reading_frame" title="Open reading frame" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">open reading frame</a> that can be transcribed, as well as <a href="http://en.wikipedia.org/wiki/Regulatory_sequence" title="Regulatory sequence" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">regulatory sequences</a> such as <a href="http://en.wikipedia.org/wiki/Promoter_(biology)" title="Promoter (biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">promoters</a> and <a href="http://en.wikipedia.org/wiki/Enhancer_(genetics)" title="Enhancer (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enhancers</a>, which control the transcription of the open reading frame.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In many <a href="http://en.wikipedia.org/wiki/Species" title="Species" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">species</a>, only a small fraction of the total sequence of the <a href="http://en.wikipedia.org/wiki/Genome" title="Genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genome</a> encodes protein. For example, only about 1.5% of the human genome consists of protein-coding <a href="http://en.wikipedia.org/wiki/Exon" title="Exon" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">exons</a>, with over 50% of human DNA consisting of non-coding <a href="http://en.wikipedia.org/wiki/Repeated_sequence_(DNA)" title="Repeated sequence (DNA)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">repetitive sequences</a>.<sup id="cite_ref-90" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-90" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[90]</a></sup> The reasons for the presence of so much <a href="http://en.wikipedia.org/wiki/Noncoding_DNA" title="Noncoding DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">noncoding DNA</a> in eukaryotic genomes and the extraordinary differences in <a href="http://en.wikipedia.org/wiki/Genome_size" title="Genome size" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genome size</a>, or <i><a href="http://en.wikipedia.org/wiki/C-value" title="C-value" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">C-value</a></i>, among species represent a long-standing puzzle known as the "<a href="http://en.wikipedia.org/wiki/C-value_enigma" title="C-value enigma" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">C-value enigma</a>".<sup id="cite_ref-91" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-91" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[91]</a></sup> However, some DNA sequences that do not code protein may still encode functional <a href="http://en.wikipedia.org/wiki/Non-coding_RNA" title="Non-coding RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">non-coding RNA</a> molecules, which are involved in the <a href="http://en.wikipedia.org/wiki/Regulation_of_gene_expression" title="Regulation of gene expression" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">regulation of gene expression</a>.<sup id="cite_ref-92" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-92" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[92]</a></sup></p>
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<a href="http://en.wikipedia.org/wiki/T7_RNA_polymerase" title="T7 RNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">T7 RNA polymerase</a> (blue) producing a mRNA (green) from a DNA template (orange).<sup id="cite_ref-93" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-93" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[93]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Some noncoding DNA sequences play structural roles in chromosomes. <a href="http://en.wikipedia.org/wiki/Telomere" title="Telomere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Telomeres</a> and <a href="http://en.wikipedia.org/wiki/Centromere" title="Centromere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">centromeres</a> typically contain few genes, but are important for the function and stability of chromosomes.<sup id="cite_ref-Nugent_56-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nugent-56" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[56]</a></sup><sup id="cite_ref-94" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-94" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[94]</a></sup> An abundant form of noncoding DNA in humans are <a href="http://en.wikipedia.org/wiki/Pseudogene" title="Pseudogene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">pseudogenes</a>, which are copies of genes that have been disabled by mutation.<sup id="cite_ref-95" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-95" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[95]</a></sup> These sequences are usually just molecular <a href="http://en.wikipedia.org/wiki/Fossil" title="Fossil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">fossils</a>, although they can occasionally serve as raw genetic material for the creation of new genes through the process of <a href="http://en.wikipedia.org/wiki/Gene_duplication" title="Gene duplication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene duplication</a> and <a href="http://en.wikipedia.org/wiki/Divergent_evolution" title="Divergent evolution" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">divergence</a>.<sup id="cite_ref-96" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-96" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[96]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Transcription_and_translation">Transcription and translation</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Genetic_code" title="Genetic code" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic code</a>, <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" title="Transcription (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Transcription (genetics)</a>, <a href="http://en.wikipedia.org/wiki/Protein_biosynthesis" title="Protein biosynthesis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Protein biosynthesis</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A gene is a sequence of DNA that contains genetic information and can influence the <a href="http://en.wikipedia.org/wiki/Phenotype" title="Phenotype" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phenotype</a> of an organism. Within a gene, the sequence of bases along a DNA strand defines a <a href="http://en.wikipedia.org/wiki/Messenger_RNA" title="Messenger RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">messenger RNA</a> sequence, which then defines one or more protein sequences. The relationship between the nucleotide sequences of genes and the <a href="http://en.wikipedia.org/wiki/Amino_acid" title="Amino acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">amino-acid</a> sequences of proteins is determined by the rules of <a href="http://en.wikipedia.org/wiki/Translation_(biology)" title="Translation (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">translation</a>, known collectively as the <a href="http://en.wikipedia.org/wiki/Genetic_code" title="Genetic code" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic code</a>. The genetic code consists of three-letter 'words' called <i>codons</i> formed from a sequence of three nucleotides (e.g. ACT, CAG, TTT).</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In transcription, the codons of a gene are copied into messenger RNA by <a href="http://en.wikipedia.org/wiki/RNA_polymerase" title="RNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase</a>. This RNA copy is then decoded by a <a href="http://en.wikipedia.org/wiki/Ribosome" title="Ribosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ribosome</a>that reads the RNA sequence by base-pairing the messenger RNA to <a href="http://en.wikipedia.org/wiki/Transfer_RNA" title="Transfer RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transfer RNA</a>, which carries amino acids. Since there are 4 bases in 3-letter combinations, there are 64 possible codons (<img class="tex" alt="4^3" src="http://upload.wikimedia.org/math/2/9/b/29b8a6aa9d0f15d19fae3aa4c6d6c883.png" style="border: none; vertical-align: middle; margin: 0px;" /> combinations). These encode the twenty <a href="http://en.wikipedia.org/wiki/List_of_standard_amino_acids" title="List of standard amino acids" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">standard amino acids</a>, giving most amino acids more than one possible codon. There are also three 'stop' or 'nonsense' codons signifying the end of the coding region; these are the TAA, TGA and TAG codons.</p>
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DNA replication. The double helix is unwound by a <a href="http://en.wikipedia.org/wiki/Helicase" title="Helicase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">helicase</a> and <a href="http://en.wikipedia.org/wiki/Topoisomerase" title="Topoisomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">topoisomerase</a>. Next, one <a href="http://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA polymerase</a> produces the <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">leading strand</a> copy. Another DNA polymerase binds to the <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">lagging strand</a>. This enzyme makes discontinuous segments (called <a href="http://en.wikipedia.org/wiki/Okazaki_fragment" title="Okazaki fragment" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Okazaki fragments</a>) before <a href="http://en.wikipedia.org/wiki/DNA_ligase" title="DNA ligase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA ligase</a> joins them together.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Replication">Replication</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Cell_division" title="Cell division" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Cell division</a> is essential for an organism to grow, but, when a cell divides, it must replicate the DNA in its genome so that the two daughter cells have the same genetic information as their parent. The double-stranded structure of DNA provides a simple mechanism for <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a>. Here, the two strands are separated and then each strand's <a href="http://en.wikipedia.org/wiki/Complementary_DNA" title="Complementary DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">complementary DNA</a> sequence is recreated by an<a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzyme</a> called <a href="http://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA polymerase</a>. This enzyme makes the complementary strand by finding the correct base through complementary base pairing, and bonding it onto the original strand. As DNA polymerases can only extend a DNA strand in a 5′ to 3′ direction, different mechanisms are used to copy the antiparallel strands of the double helix.<sup id="cite_ref-97" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-97" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[97]</a></sup> In this way, the base on the old strand dictates which base appears on the new strand, and the cell ends up with a perfect copy of its DNA.</p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Interactions_with_proteins">Interactions with proteins</span></h2>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">All the functions of DNA depend on interactions with proteins. These <a href="http://en.wikipedia.org/wiki/Protein_interactions" title="Protein interactions" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein interactions</a> can be non-specific, or the protein can bind specifically to a single DNA sequence. Enzymes can also bind to DNA and of these, the polymerases that copy the DNA base sequence in transcription and DNA replication are particularly important.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="DNA-binding_proteins">DNA-binding proteins</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA-binding_protein" title="DNA-binding protein" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA-binding protein</a></div>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; font-size: 12px; padding: 3px !important;">Interaction of DNA (shown in orange) with<a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histones</a> (shown in blue). These proteins' basic amino acids bind to the acidic phosphate groups on DNA.</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held in complexes with structural proteins. These proteins organize the DNA into a compact structure called <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromatin</a>. In eukaryotes this structure involves DNA binding to a complex of small basic proteins called <a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histones</a>, while in prokaryotes multiple types of proteins are involved.<sup id="cite_ref-98" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-98" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[98]</a></sup><sup id="cite_ref-99" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-99" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[99]</a></sup> The histones form a disk-shaped complex called a <a href="http://en.wikipedia.org/wiki/Nucleosome" title="Nucleosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleosome</a>, which contains two complete turns of double-stranded DNA wrapped around its surface. These non-specific interactions are formed through basic residues in the histones making<a href="http://en.wikipedia.org/wiki/Ionic_bond" title="Ionic bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ionic bonds</a> to the acidic sugar-phosphate backbone of the DNA, and are therefore largely independent of the base sequence.<sup id="cite_ref-100" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-100" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[100]</a></sup>Chemical modifications of these basic amino acid residues include <a href="http://en.wikipedia.org/wiki/Methylation" title="Methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methylation</a>, <a href="http://en.wikipedia.org/wiki/Phosphorylation" title="Phosphorylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphorylation</a> and <a href="http://en.wikipedia.org/wiki/Acetylation" title="Acetylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">acetylation</a>.<sup id="cite_ref-101" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-101" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[101]</a></sup> These chemical changes alter the strength of the interaction between the DNA and the histones, making the DNA more or less accessible to<a href="http://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription factors</a> and changing the rate of transcription.<sup id="cite_ref-102" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-102" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[102]</a></sup> Other non-specific DNA-binding proteins in chromatin include the high-mobility group proteins, which bind to bent or distorted DNA.<sup id="cite_ref-103" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-103" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[103]</a></sup> These proteins are important in bending arrays of nucleosomes and arranging them into the larger structures that make up chromosomes.<sup id="cite_ref-104" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-104" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[104]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. In humans, replication<a href="http://en.wikipedia.org/wiki/Protein_A" title="Protein A" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein A</a> is the best-understood member of this family and is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair.<sup id="cite_ref-105" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-105" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[105]</a></sup> These binding proteins seem to stabilize single-stranded DNA and protect it from forming <a href="http://en.wikipedia.org/wiki/Stem-loop" title="Stem-loop" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">stem-loops</a> or being degraded by <a href="http://en.wikipedia.org/wiki/Nuclease" title="Nuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleases</a>.</p>
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The lambda repressor <a href="http://en.wikipedia.org/wiki/Helix-turn-helix" title="Helix-turn-helix" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">helix-turn-helix</a> transcription factor bound to its DNA target<sup id="cite_ref-106" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-106" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[106]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In contrast, other proteins have evolved to bind to particular DNA sequences. The most intensively studied of these are the various <a href="http://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription factors</a>, which are proteins that regulate transcription. Each transcription factor binds to one particular set of DNA sequences and activates or inhibits the transcription of genes that have these sequences close to their promoters. The transcription factors do this in two ways. Firstly, they can bind the RNA polymerase responsible for transcription, either directly or through other mediator proteins; this locates the polymerase at the promoter and allows it to begin transcription.<sup id="cite_ref-107" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-107" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[107]</a></sup> Alternatively, transcription factors can bind <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> that modify the histones at the promoter. This changes the accessibility of the DNA template to the polymerase.<sup id="cite_ref-108" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-108" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[108]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">As these DNA targets can occur throughout an organism's genome, changes in the activity of one type of transcription factor can affect thousands of genes.<sup id="cite_ref-109" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-109" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[109]</a></sup> Consequently, these proteins are often the targets of the <a href="http://en.wikipedia.org/wiki/Signal_transduction" title="Signal transduction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">signal transduction</a> processes that control responses to environmental changes or <a href="http://en.wikipedia.org/wiki/Cellular_differentiation" title="Cellular differentiation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cellular differentiation</a> and development. The specificity of these transcription factors' interactions with DNA come from the proteins making multiple contacts to the edges of the DNA bases, allowing them to "read" the DNA sequence. Most of these base-interactions are made in the major groove, where the bases are most accessible.<sup id="cite_ref-Pabo1984_25-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Pabo1984-25" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[25]</a></sup></p>
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The <a href="http://en.wikipedia.org/wiki/Restriction_enzyme" title="Restriction enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction enzyme</a> <a href="http://en.wikipedia.org/wiki/EcoRV" title="EcoRV" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">EcoRV</a>(green) in a complex with its substrate DNA<sup id="cite_ref-110" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-110" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[110]</a></sup></div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="DNA-modifying_enzymes">DNA-modifying enzymes</span></h3>
<h4 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 15.199999809265137px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Nucleases_and_ligases">Nucleases and ligases</span></h4>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Nuclease" title="Nuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nucleases</a> are <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> that cut DNA strands by catalyzing the <a href="http://en.wikipedia.org/wiki/Hydrolysis" title="Hydrolysis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrolysis</a> of the <a href="http://en.wikipedia.org/wiki/Phosphodiester_bond" title="Phosphodiester bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphodiester bonds</a>. Nucleases that hydrolyse nucleotides from the ends of DNA strands are called <a href="http://en.wikipedia.org/wiki/Exonuclease" title="Exonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">exonucleases</a>, while<a href="http://en.wikipedia.org/wiki/Endonuclease" title="Endonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">endonucleases</a> cut within strands. The most frequently used nucleases in <a href="http://en.wikipedia.org/wiki/Molecular_biology" title="Molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular biology</a> are the<a href="http://en.wikipedia.org/wiki/Restriction_enzyme" title="Restriction enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction endonucleases</a>, which cut DNA at specific sequences. For instance, the EcoRV enzyme shown to the left recognizes the 6-base sequence 5′-GATATC-3′ and makes a cut at the vertical line. In nature, these enzymes protect <a href="http://en.wikipedia.org/wiki/Bacteria" title="Bacteria" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacteria</a> against <a href="http://en.wikipedia.org/wiki/Bacteriophage" title="Bacteriophage" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phage</a> infection by digesting the phage DNA when it enters the bacterial cell, acting as part of the <a href="http://en.wikipedia.org/wiki/Restriction_modification_system" title="Restriction modification system" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction modification system</a>.<sup id="cite_ref-111" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-111" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[111]</a></sup> In technology, these sequence-specific nucleases are used in <a href="http://en.wikipedia.org/wiki/Molecular_cloning" title="Molecular cloning" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular cloning</a> and <a href="http://en.wikipedia.org/wiki/Genetic_fingerprinting" title="Genetic fingerprinting" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA fingerprinting</a>.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Enzymes called <a href="http://en.wikipedia.org/wiki/DNA_ligase" title="DNA ligase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA ligases</a> can rejoin cut or broken DNA strands.<sup id="cite_ref-Doherty_112-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Doherty-112" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[112]</a></sup> Ligases are particularly important in <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">lagging strand</a> DNA replication, as they join together the short segments of DNA produced at the <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">replication fork</a> into a complete copy of the DNA template. They are also used in <a href="http://en.wikipedia.org/wiki/DNA_repair" title="DNA repair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA repair</a> and <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic recombination</a>.<sup id="cite_ref-Doherty_112-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Doherty-112" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[112]</a></sup></p>
<h4 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 15.199999809265137px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Topoisomerases_and_helicases">Topoisomerases and helicases</span></h4>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Topoisomerase" title="Topoisomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Topoisomerases</a> are enzymes with both nuclease and ligase activity. These proteins change the amount of <a href="http://en.wikipedia.org/wiki/DNA_supercoil" title="DNA supercoil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">supercoiling</a> in DNA. Some of these enzymes work by cutting the DNA helix and allowing one section to rotate, thereby reducing its level of supercoiling; the enzyme then seals the DNA break.<sup id="cite_ref-Champoux_37-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Champoux-37" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[37]</a></sup> Other types of these enzymes are capable of cutting one DNA helix and then passing a second strand of DNA through this break, before rejoining the helix.<sup id="cite_ref-113" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-113" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[113]</a></sup> Topoisomerases are required for many processes involving DNA, such as DNA replication and transcription.<sup id="cite_ref-Wang_38-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Wang-38" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[38]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Helicase" title="Helicase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Helicases</a> are proteins that are a type of <a href="http://en.wikipedia.org/wiki/Molecular_motor" title="Molecular motor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular motor</a>. They use the chemical energy in <a href="http://en.wikipedia.org/wiki/Nucleoside_triphosphate" title="Nucleoside triphosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoside triphosphates</a>, predominantly <a href="http://en.wikipedia.org/wiki/Adenosine_triphosphate" title="Adenosine triphosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ATP</a>, to break hydrogen bonds between bases and unwind the DNA double helix into single strands.<sup id="cite_ref-114" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-114" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[114]</a></sup> These enzymes are essential for most processes where enzymes need to access the DNA bases.</p>
<h4 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 15.199999809265137px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Polymerases">Polymerases</span></h4>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Polymerase" title="Polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Polymerases</a> are <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> that synthesize polynucleotide chains from <a href="http://en.wikipedia.org/wiki/Nucleoside_triphosphate" title="Nucleoside triphosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoside triphosphates</a>. The sequence of their products are copies of existing polynucleotide chains—which are called <i>templates</i>. These enzymes function by adding nucleotides onto the 3′ <a href="http://en.wikipedia.org/wiki/Hydroxyl" title="Hydroxyl" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydroxyl group</a> of the previous nucleotide in a DNA strand. As a consequence, all polymerases work in a 5′ to 3′ direction.<sup id="cite_ref-Joyce_115-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Joyce-115" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[115]</a></sup> In the <a href="http://en.wikipedia.org/wiki/Active_site" title="Active site" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">active site</a> of these enzymes, the incoming nucleoside triphosphate base-pairs to the template: this allows polymerases to accurately synthesize the complementary strand of their template. Polymerases are classified according to the type of template that they use.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In DNA replication, a DNA-dependent <a href="http://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA polymerase</a> makes a copy of a DNA sequence. Accuracy is vital in this process, so many of these polymerases have a <a href="http://en.wikipedia.org/wiki/Proofreading_(Biology)" title="Proofreading (Biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">proofreading</a> activity. Here, the polymerase recognizes the occasional mistakes in the synthesis reaction by the lack of base pairing between the mismatched nucleotides. If a mismatch is detected, a 3′ to 5′ <a href="http://en.wikipedia.org/wiki/Exonuclease" title="Exonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">exonuclease</a> activity is activated and the incorrect base removed.<sup id="cite_ref-116" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-116" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[116]</a></sup> In most organisms, DNA polymerases function in a large complex called the <a href="http://en.wikipedia.org/wiki/Replisome" title="Replisome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">replisome</a> that contains multiple accessory subunits, such as the <a href="http://en.wikipedia.org/wiki/DNA_clamp" title="DNA clamp" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA clamp</a> or <a href="http://en.wikipedia.org/wiki/Helicase" title="Helicase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">helicases</a>.<sup id="cite_ref-117" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-117" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[117]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">RNA-dependent DNA polymerases are a specialized class of polymerases that copy the sequence of an RNA strand into DNA. They include <a href="http://en.wikipedia.org/wiki/Reverse_transcriptase" title="Reverse transcriptase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">reverse transcriptase</a>, which is a <a href="http://en.wikipedia.org/wiki/Virus" title="Virus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viral</a>enzyme involved in the infection of cells by <a href="http://en.wikipedia.org/wiki/Retrovirus" title="Retrovirus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">retroviruses</a>, and <a href="http://en.wikipedia.org/wiki/Telomerase" title="Telomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomerase</a>, which is required for the replication of telomeres.<sup id="cite_ref-Greider_55-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Greider-55" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[55]</a></sup><sup id="cite_ref-118" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-118" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[118]</a></sup> Telomerase is an unusual polymerase because it contains its own RNA template as part of its structure.<sup id="cite_ref-Nugent_56-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nugent-56" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[56]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Transcription is carried out by a DNA-dependent <a href="http://en.wikipedia.org/wiki/RNA_polymerase" title="RNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase</a> that copies the sequence of a DNA strand into RNA. To begin transcribing a gene, the RNA polymerase binds to a sequence of DNA called a promoter and separates the DNA strands. It then copies the gene sequence into a <a href="http://en.wikipedia.org/wiki/Messenger_RNA" title="Messenger RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">messenger RNA</a> transcript until it reaches a region of DNA called the<a href="http://en.wikipedia.org/wiki/Terminator_(genetics)" title="Terminator (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">terminator</a>, where it halts and detaches from the DNA. As with human DNA-dependent DNA polymerases, <a href="http://en.wikipedia.org/wiki/RNA_polymerase_II" title="RNA polymerase II" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase II</a>, the enzyme that transcribes most of the genes in the human genome, operates as part of a large <a href="http://en.wikipedia.org/wiki/Protein_complex" title="Protein complex" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein complex</a> with multiple regulatory and accessory subunits.<sup id="cite_ref-119" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-119" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[119]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Genetic_recombination">Genetic recombination</span></h2>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; font-size: 12px; padding: 3px !important;">Structure of the <a href="http://en.wikipedia.org/wiki/Holliday_junction" title="Holliday junction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Holliday junction</a> intermediate in <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic recombination</a>. The four separate DNA strands are coloured red, blue, green and yellow.<sup id="cite_ref-120" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-120" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[120]</a></sup></div>
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<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic recombination</a></div>
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Recombination involves the breakage and rejoining of two chromosomes (M and F) to produce two re-arranged chromosomes (C1 and C2).</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A DNA helix usually does not interact with other segments of DNA, and in human cells the different chromosomes even occupy separate areas in the nucleus called "chromosome territories".<sup id="cite_ref-121" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-121" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[121]</a></sup> This physical separation of different chromosomes is important for the ability of DNA to function as a stable repository for information, as one of the few times chromosomes interact is during <a href="http://en.wikipedia.org/wiki/Chromosomal_crossover" title="Chromosomal crossover" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomal crossover</a> when they <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">recombine</a>. Chromosomal crossover is when two DNA helices break, swap a section and then rejoin.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Recombination allows chromosomes to exchange genetic information and produces new combinations of genes, which increases the efficiency of <a href="http://en.wikipedia.org/wiki/Natural_selection" title="Natural selection" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">natural selection</a> and can be important in the rapid evolution of new proteins.<sup id="cite_ref-122" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-122" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[122]</a></sup> Genetic recombination can also be involved in DNA repair, particularly in the cell's response to double-strand breaks.<sup id="cite_ref-123" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-123" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[123]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The most common form of chromosomal crossover is <a href="http://en.wikipedia.org/wiki/Homologous_recombination" title="Homologous recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">homologous recombination</a>, where the two chromosomes involved share very similar sequences. Non-homologous recombination can be damaging to cells, as it can produce <a href="http://en.wikipedia.org/wiki/Chromosomal_translocation" title="Chromosomal translocation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomal translocations</a>and genetic abnormalities. The recombination reaction is catalyzed by enzymes known as <a href="http://en.wikipedia.org/wiki/Recombinase" title="Recombinase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">recombinases</a>, such as <a href="http://en.wikipedia.org/wiki/RAD51" title="RAD51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RAD51</a>.<sup id="cite_ref-124" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-124" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[124]</a></sup> The first step in recombination is a double-stranded break caused by either an <a href="http://en.wikipedia.org/wiki/Endonuclease" title="Endonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">endonuclease</a> or damage to the DNA.<sup id="cite_ref-125" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-125" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[125]</a></sup> A series of steps catalyzed in part by the recombinase then leads to joining of the two helices by at least one <a href="http://en.wikipedia.org/wiki/Holliday_junction" title="Holliday junction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Holliday junction</a>, in which a segment of a single strand in each helix is annealed to the complementary strand in the other helix. The Holliday junction is a tetrahedral junction structure that can be moved along the pair of chromosomes, swapping one strand for another. The recombination reaction is then halted by cleavage of the junction and re-ligation of the released DNA.<sup id="cite_ref-126" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-126" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[126]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Evolution">Evolution</span></h2>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/RNA_world_hypothesis" title="RNA world hypothesis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA world hypothesis</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA contains the genetic information that allows all modern living things to function, grow and reproduce. However, it is unclear how long in the 4-billion-year <a href="http://en.wikipedia.org/wiki/Timeline_of_evolution" title="Timeline of evolution" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">history of life</a> DNA has performed this function, as it has been proposed that the earliest forms of life may have used RNA as their genetic material.<sup id="cite_ref-autogenerated1_127-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-autogenerated1-127" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[127]</a></sup><sup id="cite_ref-128" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-128" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[128]</a></sup> RNA may have acted as the central part of early <a href="http://en.wikipedia.org/wiki/Cell_metabolism" title="Cell metabolism" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell metabolism</a> as it can both transmit genetic information and carry out <a href="http://en.wikipedia.org/wiki/Catalysis" title="Catalysis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">catalysis</a> as part of <a href="http://en.wikipedia.org/wiki/Ribozyme" title="Ribozyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ribozymes</a>.<sup id="cite_ref-129" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-129" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[129]</a></sup> This ancient <a href="http://en.wikipedia.org/wiki/RNA_world_hypothesis" title="RNA world hypothesis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA world</a> where nucleic acid would have been used for both catalysis and genetics may have influenced the <a href="http://en.wikipedia.org/wiki/Evolution" title="Evolution" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">evolution</a> of the current genetic code based on four nucleotide bases. This would occur, since the number of different bases in such an organism is a trade-off between a small number of bases increasing replication accuracy and a large number of bases increasing the catalytic efficiency of ribozymes.<sup id="cite_ref-130" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-130" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[130]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">However, there is no direct evidence of ancient genetic systems, as recovery of DNA from most fossils is impossible. This is because DNA survives in the environment for less than one million years, and slowly degrades into short fragments in solution.<sup id="cite_ref-131" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-131" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[131]</a></sup> Claims for older DNA have been made, most notably a report of the isolation of a viable bacterium from a salt crystal 250 million years old,<sup id="cite_ref-132" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-132" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[132]</a></sup> but these claims are controversial.<sup id="cite_ref-133" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-133" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[133]</a></sup><sup id="cite_ref-134" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-134" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[134]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">On 8 August 2011, a report, based on <a href="http://en.wikipedia.org/wiki/NASA" title="NASA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">NASA</a> studies with <a href="http://en.wikipedia.org/wiki/Meteorites" title="Meteorites" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">meteorites</a> found on <a href="http://en.wikipedia.org/wiki/Earth" title="Earth" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Earth</a>, was published suggesting building blocks of DNA (<a href="http://en.wikipedia.org/wiki/Adenine" title="Adenine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenine</a>, <a href="http://en.wikipedia.org/wiki/Guanine" title="Guanine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">guanine</a> and related <a href="http://en.wikipedia.org/wiki/Organic_molecules" title="Organic molecules" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">organic molecules</a>) may have been formed extraterrestrially in <a href="http://en.wikipedia.org/wiki/Outer_space" title="Outer space" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">outer space</a>.<sup id="cite_ref-Callahan_135-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Callahan-135" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[135]</a></sup><sup id="cite_ref-Steigerwald_136-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Steigerwald-136" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[136]</a></sup><sup id="cite_ref-DNA_137-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-DNA-137" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[137]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Uses_in_technology">Uses in technology</span></h2>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Genetic_engineering">Genetic engineering</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Molecular_biology" title="Molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular biology</a>, <a href="http://en.wikipedia.org/wiki/Nucleic_acid_methods" title="Nucleic acid methods" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleic acid methods</a> and <a href="http://en.wikipedia.org/wiki/Genetic_engineering" title="Genetic engineering" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic engineering</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Methods have been developed to purify DNA from organisms, such as <a href="http://en.wikipedia.org/wiki/Phenol-chloroform_extraction" title="Phenol-chloroform extraction" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phenol-chloroform extraction</a>, and to manipulate it in the laboratory, such as <a href="http://en.wikipedia.org/wiki/Restriction_digest" title="Restriction digest" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction digests</a> and the<a href="http://en.wikipedia.org/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polymerase chain reaction</a>. Modern <a href="http://en.wikipedia.org/wiki/Biology" title="Biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">biology</a> and <a href="http://en.wikipedia.org/wiki/Biochemistry" title="Biochemistry" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">biochemistry</a> make intensive use of these techniques in recombinant DNA technology. <a href="http://en.wikipedia.org/wiki/Recombinant_DNA" title="Recombinant DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Recombinant DNA</a> is a man-made DNA sequence that has been assembled from other DNA sequences. They can be <a href="http://en.wikipedia.org/wiki/Transformation_(genetics)" title="Transformation (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transformed</a> into organisms in the form of <a href="http://en.wikipedia.org/wiki/Plasmid" title="Plasmid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">plasmids</a> or in the appropriate format, by using a <a href="http://en.wikipedia.org/wiki/Viral_vector" title="Viral vector" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viral vector</a>.<sup id="cite_ref-138" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-138" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[138]</a></sup> The <a href="http://en.wikipedia.org/wiki/Genetic_engineering" title="Genetic engineering" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetically modified</a> organisms produced can be used to produce products such as recombinant <a href="http://en.wikipedia.org/wiki/Protein" title="Protein" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">proteins</a>, used in <a href="http://en.wikipedia.org/wiki/Medical_research" title="Medical research" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">medical research</a>,<sup id="cite_ref-139" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-139" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[139]</a></sup> or be grown in<a href="http://en.wikipedia.org/wiki/Agriculture" title="Agriculture" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">agriculture</a>.<sup id="cite_ref-140" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-140" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[140]</a></sup><sup id="cite_ref-141" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-141" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[141]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Forensics">Forensics</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_profiling" title="DNA profiling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA profiling</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Forensic_science" title="Forensic science" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Forensic scientists</a> can use DNA in <a href="http://en.wikipedia.org/wiki/Blood" title="Blood" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">blood</a>, <a href="http://en.wikipedia.org/wiki/Semen" title="Semen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">semen</a>, <a href="http://en.wikipedia.org/wiki/Skin" title="Skin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">skin</a>, <a href="http://en.wikipedia.org/wiki/Saliva" title="Saliva" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">saliva</a> or <a href="http://en.wikipedia.org/wiki/Hair" title="Hair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hair</a> found at a <a href="http://en.wikipedia.org/wiki/Crime_scene" title="Crime scene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">crime scene</a> to identify a matching DNA of an individual, such as a perpetrator. This process is formally termed <a href="http://en.wikipedia.org/wiki/DNA_profiling" title="DNA profiling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA profiling</a>, but may also be called "<a href="http://en.wikipedia.org/wiki/Genetic_fingerprinting" title="Genetic fingerprinting" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic fingerprinting</a>". In DNA profiling, the lengths of variable sections of repetitive DNA, such as <a href="http://en.wikipedia.org/wiki/Short_tandem_repeat" title="Short tandem repeat" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">short tandem repeats</a> and <a href="http://en.wikipedia.org/wiki/Minisatellite" title="Minisatellite" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">minisatellites</a>, are compared between people. This method is usually an extremely reliable technique for identifying a matching DNA.<sup id="cite_ref-142" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-142" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[142]</a></sup> However, identification can be complicated if the scene is contaminated with DNA from several people.<sup id="cite_ref-143" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-143" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[143]</a></sup> DNA profiling was developed in 1984 by British geneticist Sir <a href="http://en.wikipedia.org/wiki/Alec_Jeffreys" title="Alec Jeffreys" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Alec Jeffreys</a>,<sup id="cite_ref-144" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-144" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[144]</a></sup> and first used in forensic science to convict Colin Pitchfork in the 1988 <a href="http://en.wikipedia.org/wiki/Colin_Pitchfork" title="Colin Pitchfork" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Enderby murders</a> case.<sup id="cite_ref-145" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-145" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[145]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The development of forensic science, and the ability to now obtain genetic matching on minute samples of blood, skin, saliva or hair has led to a re-examination of a number of cases. Evidence can now be uncovered that was not scientifically possible at the time of the original examination. Combined with the removal of the <a href="http://en.wikipedia.org/wiki/Double_jeopardy" title="Double jeopardy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">double jeopardy</a> law in some places, this can allow cases to be reopened where previous trials have failed to produce sufficient evidence to convince a jury. People charged with serious crimes may be required to provide a sample of DNA for matching purposes. The most obvious defence to DNA matches obtained forensically is to claim that cross-contamination of evidence has taken place. This has resulted in meticulous strict handling procedures with new cases of serious crime. DNA profiling is also used to identify victims of mass casualty incidents.<sup id="cite_ref-146" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-146" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[146]</a></sup> As well as positively identifying bodies or body parts in serious accidents, DNA profiling is being successfully used to identify individual victims in mass war graves – matching to family members.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Bioinformatics">Bioinformatics</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Bioinformatics" title="Bioinformatics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bioinformatics</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Bioinformatics" title="Bioinformatics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bioinformatics</a> involves the manipulation, searching, and <a href="http://en.wikipedia.org/wiki/Data_mining" title="Data mining" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">data mining</a> of biological data, and this includes DNA sequence data. The development of techniques to store and search DNA sequences have led to widely applied advances in <a href="http://en.wikipedia.org/wiki/Computer_science" title="Computer science" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">computer science</a>, especially <a href="http://en.wikipedia.org/wiki/String_searching_algorithm" title="String searching algorithm" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">string searching algorithms</a>, <a href="http://en.wikipedia.org/wiki/Machine_learning" title="Machine learning" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">machine learning</a> and <a href="http://en.wikipedia.org/wiki/Database_theory" title="Database theory" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">database theory</a>.<sup id="cite_ref-147" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-147" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[147]</a></sup> String searching or matching algorithms, which find an occurrence of a sequence of letters inside a larger sequence of letters, were developed to search for specific sequences of nucleotides.<sup id="cite_ref-148" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-148" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[148]</a></sup> The DNA sequence may be <a href="http://en.wikipedia.org/wiki/Sequence_alignment" title="Sequence alignment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aligned</a> with other DNA sequences to identify <a href="http://en.wikipedia.org/wiki/Homology_(biology)" title="Homology (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">homologous</a> sequences and locate the specific <a href="http://en.wikipedia.org/wiki/Mutation" title="Mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutations</a> that make them distinct. These techniques, especially<a href="http://en.wikipedia.org/wiki/Multiple_sequence_alignment" title="Multiple sequence alignment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">multiple sequence alignment</a>, are used in studying <a href="http://en.wikipedia.org/wiki/Phylogenetics" title="Phylogenetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phylogenetic</a> relationships and protein function.<sup id="cite_ref-149" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-149" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[149]</a></sup> Data sets representing entire genomes' worth of DNA sequences, such as those produced by the <a href="http://en.wikipedia.org/wiki/Human_Genome_Project" title="Human Genome Project" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Human Genome Project</a>, are difficult to use without the annotations that identify the locations of genes and regulatory elements on each chromosome. Regions of DNA sequence that have the characteristic patterns associated with protein- or RNA-coding genes can be identified by <a href="http://en.wikipedia.org/wiki/Gene_prediction" title="Gene prediction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene finding</a> algorithms, which allow researchers to predict the presence of particular <a href="http://en.wikipedia.org/wiki/Gene_product" title="Gene product" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene products</a> and their possible functions in an organism even before they have been isolated experimentally.<sup id="cite_ref-Mount_150-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Mount-150" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[150]</a></sup> Entire genomes may also be compared, which can shed light on the evolutionary history of particular organism and permit the examination of complex evolutionary events.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="DNA_nanotechnology">DNA nanotechnology</span></h3>
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The DNA structure at left (schematic shown) will self-assemble into the structure visualized by <a href="http://en.wikipedia.org/wiki/Atomic_force_microscope" title="Atomic force microscope" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">atomic force microscopy</a> at right. <a href="http://en.wikipedia.org/wiki/DNA_nanotechnology" title="DNA nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA nanotechnology</a> is the field that seeks to design nanoscale structures using the <a href="http://en.wikipedia.org/wiki/Molecular_recognition" title="Molecular recognition" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular recognition</a> properties of DNA molecules. Image from<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1371/journal.pbio.0020073" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Strong, 2004</a>.</div>
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<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_nanotechnology" title="DNA nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA nanotechnology</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA nanotechnology uses the unique <a href="http://en.wikipedia.org/wiki/Molecular_recognition" title="Molecular recognition" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular recognition</a> properties of DNA and other nucleic acids to create self-assembling branched DNA complexes with useful properties.<sup id="cite_ref-151" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-151" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[151]</a></sup> DNA is thus used as a structural material rather than as a carrier of biological information. This has led to the creation of two-dimensional periodic lattices (both tile-based as well as using the "<a href="http://en.wikipedia.org/wiki/DNA_origami" title="DNA origami" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA origami</a>" method) as well as three-dimensional structures in the shapes of <a href="http://en.wikipedia.org/wiki/Polyhedron" title="Polyhedron" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polyhedra</a>.<sup id="cite_ref-152" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-152" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[152]</a></sup> <a href="http://en.wikipedia.org/wiki/DNA_machine" title="DNA machine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nanomechanical devices</a> and <a href="http://en.wikipedia.org/wiki/DNA_computing" title="DNA computing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">algorithmic self-assembly</a> have also been demonstrated,<sup id="cite_ref-153" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-153" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[153]</a></sup> and these DNA structures have been used to template the arrangement of other molecules such as <a href="http://en.wikipedia.org/wiki/Colloidal_gold" title="Colloidal gold" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gold nanoparticles</a> and <a href="http://en.wikipedia.org/wiki/Streptavidin" title="Streptavidin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">streptavidin</a> proteins.<sup id="cite_ref-154" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-154" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[154]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="History_and_anthropology">History and anthropology</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Phylogenetics" title="Phylogenetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Phylogenetics</a> and <a href="http://en.wikipedia.org/wiki/Genetic_genealogy" title="Genetic genealogy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic genealogy</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Because DNA collects mutations over time, which are then inherited, it contains historical information, and, by comparing DNA sequences, geneticists can infer the evolutionary history of organisms, their <a href="http://en.wikipedia.org/wiki/Phylogenetics" title="Phylogenetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phylogeny</a>.<sup id="cite_ref-155" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-155" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[155]</a></sup>This field of phylogenetics is a powerful tool in <a href="http://en.wikipedia.org/wiki/Evolutionary_biology" title="Evolutionary biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">evolutionary biology</a>. If DNA sequences within a species are compared, <a href="http://en.wikipedia.org/wiki/Population_genetics" title="Population genetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">population geneticists</a> can learn the history of particular populations. This can be used in studies ranging from <a href="http://en.wikipedia.org/wiki/Ecological_genetics" title="Ecological genetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ecological genetics</a> to <a href="http://en.wikipedia.org/wiki/Anthropology" title="Anthropology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">anthropology</a>; For example, DNA evidence is being used to try to identify the <a href="http://en.wikipedia.org/wiki/Ten_Lost_Tribes" title="Ten Lost Tribes" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Ten Lost Tribes of Israel</a>.<sup id="cite_ref-156" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-156" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[156]</a></sup><sup id="cite_ref-157" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-157" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[157]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA has also been used to look at modern family relationships, such as establishing family relationships between the descendants of <a href="http://en.wikipedia.org/wiki/Sally_Hemings" title="Sally Hemings" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Sally Hemings</a> and <a href="http://en.wikipedia.org/wiki/Thomas_Jefferson" title="Thomas Jefferson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Thomas Jefferson</a>. This usage is closely related to the use of DNA in criminal investigations detailed above. Indeed, some criminal investigations have been solved when DNA from crime scenes has matched relatives of the guilty individual.<sup id="cite_ref-158" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-158" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[158]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Information_storage">Information storage</span></h3>
<div class="rellink relarticle mainarticle" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Main article: <a href="http://en.wikipedia.org/wiki/DNA_digital_data_storage" title="DNA digital data storage" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA digital data storage</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In a paper published in Nature in January, 2013, scientists from the <a href="http://en.wikipedia.org/wiki/European_Bioinformatics_Institute" title="European Bioinformatics Institute" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">European Bioinformatics Institute</a> and <a href="http://en.wikipedia.org/wiki/Agilent_Technologies" title="Agilent Technologies" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Agilent Technologies</a> proposed a mechanism to use DNA's ability to code information as a means of digital data storage. The group was able to encode 739 kilobytes of data into DNA code, synthesize the actual DNA, then sequence the DNA and decode the information back to its original form, with a reported 100% accuracy. The encoded information consisted of text files and audio files. A prior experiment was published in August 2012. It was conducted by researchers at <a href="http://en.wikipedia.org/wiki/Harvard_University" title="Harvard University" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Harvard University</a>, where the text of a 54,000-word book was encoded in DNA.<sup id="cite_ref-159" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-159" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[159]</a></sup><sup id="cite_ref-160" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-160" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[160]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="History_of_DNA_research">History of DNA research</span></h2>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/History_of_molecular_biology" title="History of molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">History of molecular biology</a></div>
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James Watson and Francis Crick (right), co-originators of the double-helix model, with Maclyn McCarty (left).</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA was first isolated by the Swiss physician <a href="http://en.wikipedia.org/wiki/Friedrich_Miescher" title="Friedrich Miescher" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Friedrich Miescher</a> who, in 1869, discovered a microscopic substance in the pus of discarded surgical bandages. As it resided in the nuclei of cells, he called it "nuclein".<sup id="cite_ref-161" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-161" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[161]</a></sup> In 1878, Albrecht Kossel isolated the non-protein component of "nuclein", nucleic acid, and later isolated its five primary <a href="http://en.wikipedia.org/wiki/Nucleobases" title="Nucleobases" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleobases</a>.<sup id="cite_ref-Yale_Jones_1953_162-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Yale_Jones_1953-162" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[162]</a></sup> In 1919, Phoebus Levene identified the base, sugar and phosphate nucleotide unit.<sup id="cite_ref-163" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-163" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[163]</a></sup> Levene suggested that DNA consisted of a string of nucleotide units linked together through the phosphate groups. However, Levene thought the chain was short and the bases repeated in a fixed order. In 1937 <a href="http://en.wikipedia.org/wiki/William_Astbury" title="William Astbury" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">William Astbury</a> produced the first X-ray diffraction patterns that showed that DNA had a regular structure.<sup id="cite_ref-164" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-164" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[164]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In 1927, <a href="http://en.wikipedia.org/wiki/Nikolai_Koltsov" title="Nikolai Koltsov" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nikolai Koltsov</a> proposed that inherited traits would be inherited via a "giant hereditary molecule" made up of "two mirror strands that would replicate in a semi-conservative fashion using each strand as a template".<sup id="cite_ref-Soyfer_165-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Soyfer-165" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[165]</a></sup> In 1928, <a href="http://en.wikipedia.org/wiki/Frederick_Griffith" title="Frederick Griffith" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Frederick Griffith</a> discovered that <a href="http://en.wikipedia.org/wiki/Trait_(biology)" title="Trait (biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">traits</a> of the "smooth" form of <i>Pneumococcus</i> could be transferred to the "rough" form of the same bacteria by mixing killed "smooth" bacteria with the live "rough" form.<sup id="cite_ref-166" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-166" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[166]</a></sup> This system provided the first clear suggestion that DNA carries genetic information—the <a href="http://en.wikipedia.org/wiki/Avery%E2%80%93MacLeod%E2%80%93McCarty_experiment" title="Avery–MacLeod–McCarty experiment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Avery–MacLeod–McCarty experiment</a>—when <a href="http://en.wikipedia.org/wiki/Oswald_Avery" title="Oswald Avery" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Oswald Avery</a>, along with coworkers <a href="http://en.wikipedia.org/wiki/Colin_Munro_MacLeod" title="Colin Munro MacLeod" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Colin MacLeod</a> and <a href="http://en.wikipedia.org/wiki/Maclyn_McCarty" title="Maclyn McCarty" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Maclyn McCarty</a>, identified DNA as the <a href="http://en.wikipedia.org/wiki/Griffith%27s_experiment" title="Griffith's experiment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transforming principle</a> in 1943.<sup id="cite_ref-167" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-167" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[167]</a></sup> DNA's role in <a href="http://en.wikipedia.org/wiki/Heredity" title="Heredity" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">heredity</a> was confirmed in 1952, when <a href="http://en.wikipedia.org/wiki/Alfred_Hershey" title="Alfred Hershey" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Alfred Hershey</a> and <a href="http://en.wikipedia.org/wiki/Martha_Chase" title="Martha Chase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Martha Chase</a> in the <a href="http://en.wikipedia.org/wiki/Hershey%E2%80%93Chase_experiment" title="Hershey–Chase experiment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Hershey–Chase experiment</a> showed that DNA is the <a href="http://en.wikipedia.org/wiki/Genetic_material" title="Genetic material" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic material</a> of the <a href="http://en.wikipedia.org/wiki/Enterobacteria_phage_T2" title="Enterobacteria phage T2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">T2 phage</a>.<sup id="cite_ref-168" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-168" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[168]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In 1953, <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">James Watson</a> and <a href="http://en.wikipedia.org/wiki/Francis_Crick" title="Francis Crick" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Francis Crick</a> suggested what is now accepted as the first correct double-helix model of <a href="http://en.wikipedia.org/wiki/Molecular_structure_of_Nucleic_Acids" title="Molecular structure of Nucleic Acids" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA structure</a> in the journal <i><a href="http://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nature</a></i>.<sup id="cite_ref-FWPUB_5-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-FWPUB-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[5]</a></sup> Their double-helix, molecular model of DNA was then based on a single <a href="http://en.wikipedia.org/wiki/X-ray_diffraction" title="X-ray diffraction" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-ray diffraction</a> image (labeled as "<a href="http://en.wikipedia.org/wiki/Photo_51" title="Photo 51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Photo 51</a>")<sup id="cite_ref-169" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-169" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[169]</a></sup> taken by <a href="http://en.wikipedia.org/wiki/Rosalind_Franklin" title="Rosalind Franklin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Rosalind Franklin</a> and <a href="http://en.wikipedia.org/wiki/Raymond_Gosling" title="Raymond Gosling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Raymond Gosling</a> in May 1952, as well as the information that the DNA bases are paired — also obtained through private communications from Erwin Chargaff in the previous years. <a href="http://en.wikipedia.org/wiki/Chargaff%27s_rules" title="Chargaff's rules" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chargaff's rules</a> played a very important role in establishing double-helix configurations for B-DNA as well as A-DNA.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Experimental evidence supporting the Watson and Crick model was published in a series of five articles in the same issue of <i>Nature</i>.<sup id="cite_ref-NatureDNA50_170-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatureDNA50-170" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[170]</a></sup> Of these, Franklin and Gosling's paper was the first publication of their own X-ray diffraction data and original analysis method that partially supported the Watson and Crick model;<sup id="cite_ref-NatFranGos_41-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatFranGos-41" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[41]</a></sup><sup id="cite_ref-171" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-171" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[171]</a></sup> this issue also contained an article on DNA structure by <a href="http://en.wikipedia.org/wiki/Maurice_Wilkins" title="Maurice Wilkins" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Maurice Wilkins</a> and two of his colleagues, whose analysis and <i>in vivo</i> B-DNA X-ray patterns also supported the presence <i>in vivo</i> of the double-helical DNA configurations as proposed by Crick and Watson for their double-helix molecular model of DNA in the previous two pages of <i>Nature</i>.<sup id="cite_ref-NatWilk_42-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatWilk-42" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[42]</a></sup> In 1962, after Franklin's death, Watson, Crick, and Wilkins jointly received the Nobel Prize in <a href="http://en.wikipedia.org/wiki/Nobel_Prize_in_Physiology_or_Medicine" title="Nobel Prize in Physiology or Medicine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Physiology or Medicine</a>.<sup id="cite_ref-172" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-172" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[172]</a></sup> Nobel Prizes were awarded only to living recipients at the time. A debate continues about who should receive credit for the discovery.<sup id="cite_ref-173" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-173" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[173]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In an influential presentation in 1957, Crick laid out the <a href="http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology" title="Central dogma of molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">central dogma of molecular biology</a>, which foretold the relationship between DNA, RNA, and proteins, and articulated the "adaptor hypothesis".<sup id="cite_ref-174" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-174" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[174]</a></sup> Final confirmation of the replication mechanism that was implied by the double-helical structure followed in 1958 through the Meselson–Stahl experiment.<sup id="cite_ref-175" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-175" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[175]</a></sup> Further work by Crick and coworkers showed that the genetic code was based on non-overlapping triplets of bases, called codons, allowing <a href="http://en.wikipedia.org/wiki/Har_Gobind_Khorana" title="Har Gobind Khorana" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Har Gobind Khorana</a>, <a href="http://en.wikipedia.org/wiki/Robert_W._Holley" title="Robert W. Holley" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Robert W. Holley</a> and <a href="http://en.wikipedia.org/wiki/Marshall_Warren_Nirenberg" title="Marshall Warren Nirenberg" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Marshall Warren Nirenberg</a> to decipher the genetic code.<sup id="cite_ref-176" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-176" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[176]</a></sup> These findings represent the birth of molecular biology.</p>
<div style="font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px; clear: both;"> </div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="See_also">See also</span></h2>
<div class="noprint tright portal" style="clear: right; float: right; margin: 0.5em 0px 0.5em 1em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px; border: 1px solid rgb(170, 170, 170);">
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<td style="text-align: center;"><a href="http://en.wikipedia.org/wiki/File:TPI1_structure.png" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Portal icon" src="http://upload.wikimedia.org/wikipedia/commons/thumb/1/1c/TPI1_structure.png/32px-TPI1_structure.png" width="32" height="20" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/TPI1_structure.png/48px-TPI1_structure.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1c/TPI1_structure.png/64px-TPI1_structure.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td style="padding: 0px 0.2em; vertical-align: middle; font-style: italic; font-weight: bold;"><a href="http://en.wikipedia.org/wiki/Portal:Molecular_and_Cellular_Biology" title="Portal:Molecular and Cellular Biology" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular and Cellular Biology portal</a></td>
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</table>
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<div class="column-width" style="font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px; -webkit-column-width: 20em;">
<ul style="line-height: 1.5em; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=);">
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Autosome" title="Autosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Autosome</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Crystallography" title="Crystallography" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Crystallography</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/DNA-encoded_chemical_library" title="DNA-encoded chemical library" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA-encoded chemical library</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/DNA_microarray" title="DNA microarray" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA microarray</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/DNA_sequencing" title="DNA sequencing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA sequencing</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Genetic_disorder" title="Genetic disorder" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic disorder</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Haplotype" title="Haplotype" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Haplotype</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/List_of_nucleic_acid_simulation_software" title="List of nucleic acid simulation software" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">List of nucleic acid simulation software</a>- Nucleic acid modeling</li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Meiosis" title="Meiosis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Meiosis</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Nucleic_acid_double_helix" title="Nucleic acid double helix" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nucleic acid double helix</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Nucleic_acid_notation" title="Nucleic acid notation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nucleic acid notation</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Phosphoramidite" title="Phosphoramidite" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Phosphoramidite</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Southern_blot" title="Southern blot" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Southern blot</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/X-ray_scattering_techniques" title="X-ray scattering techniques" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-ray scattering techniques</a></li>
<li style="margin-bottom: 0.1em;"><i><a href="http://en.wikipedia.org/wiki/Proteopedia" title="Proteopedia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA</a></i></li>
</ul>
</div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="References">References</span></h2>
<div class="reflist references-column-width" style="font-size: 11.199999809265137px; margin-bottom: 0.5em; font-family: sans-serif; line-height: 19.200000762939453px; -webkit-column-width: 30em; list-style-type: decimal;">
<ol class="references" style="line-height: 1.5em; margin: 0.3em 0px 0.5em 3.2em; padding: 0px; list-style-image: none; list-style-type: inherit;">
<li id="cite_note-1" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Russell, Peter (2001). <i>iGenetics</i>. New York: Benjamin Cummings. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-8053-4553-1" title="Special:BookSources/0-8053-4553-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-8053-4553-1</a>.</span></span></li>
<li id="cite_note-2" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Saenger, Wolfram (1984). <i>Principles of Nucleic Acid Structure</i>. New York: Springer-Verlag. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-387-90762-9" title="Special:BookSources/0-387-90762-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-387-90762-9</a>.</span></span></li>
<li id="cite_note-Alberts-3" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Alberts_3-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Alberts_3-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Alberts, Bruce; Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walters (2002).<i>Molecular Biology of the Cell; Fourth Edition</i>. New York and London: Garland Science. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-8153-3218-1" title="Special:BookSources/0-8153-3218-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-8153-3218-1</a>.<a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/145080076+48122761+57023651+69932405" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">145080076 48122761 57023651 69932405</a>.</span></span></li>
<li id="cite_note-Butler-4" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Butler_4-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Butler, John M. (2001). <i>Forensic DNA Typing</i>. Elsevier.<a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/978-0-12-147951-0" title="Special:BookSources/978-0-12-147951-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">978-0-12-147951-0</a>. <a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/223032110+45406517" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">223032110 45406517</a>.</span>pp. 14–15.</span></li>
<li id="cite_note-FWPUB-5" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-FWPUB_5-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-FWPUB_5-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-FWPUB_5-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>c</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Watson J.D. and Crick F.H.C. (1953). <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/watsoncrick.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A Structure for Deoxyribose Nucleic Acid"</a> (PDF). <i>Nature</i> <b>171</b>(4356): 737–738. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..737W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..737W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171737a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171737a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054692" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054692</a>.</span></span></li>
<li id="cite_note-6" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Mandelkern M, Elias J, Eden D, Crothers D (1981). "The dimensions of DNA in solution". <i>J Mol Biol</i> <b>152</b> (1): 153–61. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2F0022-2836%2881%2990099-1" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/0022-2836(81)90099-1</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7338906" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7338906</a>.</span></span></li>
<li id="cite_note-7" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Gregory S; Barlow, KF; McLay, KE; Kaul, R; Swarbreck, D; Dunham, A; Scott, CE; Howe, KL; Woodfine, K (2006). "The DNA sequence and biological annotation of human chromosome 1". <i>Nature</i> <b>441</b> (7091): 315–21.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2006Natur.441..315G" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2006Natur.441..315G</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature04727" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature04727</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16710414" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16710414</a>.</span></span></li>
<li id="cite_note-autogenerated2-8" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-autogenerated2_8-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Watson J.D. and Crick F.H.C. (1953). <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/watsoncrick.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A Structure for Deoxyribose Nucleic Acid"</a> (PDF). <i>Nature</i> <b>171</b> (4356): 737–738. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..737W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..737W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171737a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171737a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054692" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054692</a><span class="reference-accessdate">. Retrieved 4 May 2009</span>.</span></span></li>
<li id="cite_note-berg-9" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-berg_9-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-berg_9-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-berg_9-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>c</b></i></sup></a></span> <span class="reference-text">Berg J., Tymoczko J. and Stryer L. (2002)<i>Biochemistry.</i> W. H. Freeman and Company <a href="http://en.wikipedia.org/wiki/Special:BookSources/0716749556" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-7167-4955-6</a></span></li>
<li id="cite_note-IUPAC-10" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-IUPAC_10-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/misc/naabb.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Abbreviations and Symbols for Nucleic Acids, Polynucleotides and their Constituents</a> IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Retrieved 3 January 2006.</span></li>
<li id="cite_note-Ghosh-11" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Ghosh_11-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Ghosh_11-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Ghosh A, Bansal M (2003). "A glossary of DNA structures from A to Z". <i>Acta Crystallogr D</i> <b>59</b> (4): 620–6.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0907444903003251" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0907444903003251</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12657780" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12657780</a>.</span></span></li>
<li id="cite_note-12" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-12" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1D65" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">PDB 1D65</a></span></li>
<li id="cite_note-Yakovchuk2006-13" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Yakovchuk2006_13-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Yakovchuk P, Protozanova E, Frank-Kamenetskii MD (2006). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360284" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Base-stacking and base-pairing contributions into thermal stability of the DNA double helix"</a>. <i>Nucleic Acids Res.</i> <b>34</b> (2): 564–74. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fnar%2Fgkj454" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/nar/gkj454</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360284" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1360284</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16449200" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16449200</a>.</span></span></li>
<li id="cite_note-14" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-14" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Verma S, Eckstein F (1998). "Modified oligonucleotides: synthesis and strategy for users". <i>Annu. Rev. Biochem.</i><b>67</b>: 99–134. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.biochem.67.1.99" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.biochem.67.1.99</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9759484" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9759484</a>.</span></span></li>
<li id="cite_note-Kiljunen2005-15" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Kiljunen2005_15-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Kiljunen S, Hakala K, Pinta E, Huttunen S, Pluta P, Gador A, Lönnberg H, Skurnik M (2005). "Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine".<i>Microbiology</i> <b>151</b> (12): 4093–4102.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1099%2Fmic.0.28265-0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1099/mic.0.28265-0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16339954" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16339954</a>.</span></span></li>
<li id="cite_note-Simpson1998-16" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Simpson1998_16-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Simpson L (1998). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33841" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A base called J"</a>. <i>Proc Natl Acad Sci USA</i> <b>95</b> (5): 2037–2038.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.95.5.2037" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.95.5.2037</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33841" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">33841</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9482833" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9482833</a>.</span></span></li>
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<li id="cite_note-Cross1999-18" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Cross1999_18-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Cross M, Kieft R, Sabatini R, Wilm M, de Kort M, der Marel GA, van Boom JH, van Leeuwen F, Borst P <i>et al.</i>(1999). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171720" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans"</a>. <i>EMBO J</i> <b>18</b>(22): 6573–6581. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Femboj%2F18.22.6573" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/emboj/18.22.6573</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171720" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1171720</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10562569" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10562569</a>.</span></span></li>
<li id="cite_note-DiPaolo2005-19" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-DiPaolo2005_19-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">DiPaolo C, Kieft R, Cross M, Sabatini R (2005). "Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein". <i>Mol Cell</i> <b>17</b> (3): 441–451.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.molcel.2004.12.022" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.molcel.2004.12.022</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15694344" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">15694344</a>.</span></span></li>
<li id="cite_note-Vainio2009-20" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Vainio2009_20-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Vainio S, Genest PA, ter Riet B, van Luenen H, Borst P (2009). "Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J". <i>Molecular and biochemical parasitology</i> <b>164</b>(2): 157–61. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.molbiopara.2008.12.001" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.molbiopara.2008.12.001</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19114062" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19114062</a>.</span></span></li>
<li id="cite_note-Iyer2009-21" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Iyer2009_21-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Iyer LM, Tahiliani M, Rao A, Aravind L (2009). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995806" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids"</a>.<i>Cell Cycle</i> <b>8</b> (11): 1698–1710.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.4161%2Fcc.8.11.8580" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.4161/cc.8.11.8580</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995806" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2995806</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19411852" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19411852</a>.</span></span></li>
<li id="cite_note-van_Luenen2012-22" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-van_Luenen2012_22-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A <i>et al.</i>(2012). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684241" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Leishmania"</a>. <i>Cell</i> <b>150</b> (5): 909–921.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.cell.2012.07.030" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.cell.2012.07.030</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684241" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">3684241</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/22939620" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">22939620</a>.</span></span></li>
<li id="cite_note-Hazelbaker2012-23" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Hazelbaker2012_23-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Hazelbaker DZ, Buratowski S (2012). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648658" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Transcription: base J blocks the way"</a>. <i>Curr Biol</i> <b>22</b> (22): R960–2.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.cub.2012.10.010" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.cub.2012.10.010</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648658" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">3648658</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/23174300" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">23174300</a>.</span></span></li>
<li id="cite_note-24" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-24" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wing R, Drew H, Takano T, Broka C, Tanaka S, Itakura K, Dickerson R (1980). "Crystal structure analysis of a complete turn of B-DNA". <i>Nature</i> <b>287</b> (5784): 755–8.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1980Natur.287..755W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1980Natur.287..755W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F287755a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/287755a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7432492" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7432492</a>.</span></span></li>
<li id="cite_note-Pabo1984-25" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Pabo1984_25-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Pabo1984_25-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Pabo C, Sauer R (1984). "Protein-DNA recognition".<i>Annu Rev Biochem</i> <b>53</b>: 293–321.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.bi.53.070184.001453" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.bi.53.070184.001453</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/6236744" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">6236744</a>.</span></span></li>
<li id="cite_note-26" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-26" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Clausen-Schaumann H, Rief M, Tolksdorf C, Gaub H (2000). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1300792" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Mechanical stability of single DNA molecules"</a>.<i>Biophys J</i> <b>78</b> (4): 1997–2007.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2000BpJ....78.1997C" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2000BpJ....78.1997C</a>. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2FS0006-3495%2800%2976747-6" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/S0006-3495(00)76747-6</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1300792" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1300792</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10733978" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10733978</a>.</span></span></li>
<li id="cite_note-27" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-27" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Chalikian T, Völker J, Plum G, Breslauer K (1999). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22151" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A more unified picture for the thermodynamics of nucleic acid duplex melting: A characterization by calorimetric and volumetric techniques"</a>. <i>Proc Natl Acad Sci USA</i> <b>96</b> (14): 7853–8. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1999PNAS...96.7853C" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1999PNAS...96.7853C</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.96.14.7853" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.96.14.7853</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22151" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">22151</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10393911" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10393911</a>.</span></span></li>
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<li id="cite_note-35" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-35" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Lamb R, Horvath C (1991). "Diversity of coding strategies in influenza viruses". <i>Trends Genet</i> <b>7</b> (8): 261–6.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2F0168-9525%2891%2990326-L" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/0168-9525(91)90326-L</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/1771674" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1771674</a>.</span></span></li>
<li id="cite_note-36" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-36" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Benham C, Mielke S (2005). "DNA mechanics". <i>Annu Rev Biomed Eng</i> <b>7</b>: 21–53.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.bioeng.6.062403.132016" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.bioeng.6.062403.132016</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16004565" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16004565</a>.</span></span></li>
<li id="cite_note-Champoux-37" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Champoux_37-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Champoux_37-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Champoux J (2001). "DNA topoisomerases: structure, function, and mechanism". <i>Annu Rev Biochem</i><b>70</b>: 369–413. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.biochem.70.1.369" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.biochem.70.1.369</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11395412" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11395412</a>.</span></span></li>
<li id="cite_note-Wang-38" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Wang_38-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Wang_38-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wang J (2002). "Cellular roles of DNA topoisomerases: a molecular perspective". <i>Nat Rev Mol Cell Biol</i> <b>3</b> (6): 430–40. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnrm831" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nrm831</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12042765" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12042765</a>.</span></span></li>
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<li id="cite_note-40" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-40" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Franklin RE, Gosling RG (6 March 1953). <a rel="nofollow" class="external text" href="http://web.archive.org/web/20070612083334/http://hekto.med.unc.edu:8080/CARTER/carter_WWW/Bioch_134/PDF_files/Franklin_Gossling.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The Structure of Sodium Thymonucleate Fibres I. The Influence of Water Content"</a>. <i>Acta Crystallogr</i> <b>6</b> (8–9): 673–7.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0365110X53001939" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0365110X53001939</a>. Archived from <a rel="nofollow" class="external text" href="http://hekto.med.unc.edu:8080/CARTER/carter_WWW/Bioch_134/PDF_files/Franklin_Gossling.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">the original</a> on 2007-06-12.</span><br />
<span class="citation journal" style="word-wrap: break-word;">Franklin RE, Gosling RG (1953). "The structure of sodium thymonucleate fibres. II. The cylindrically symmetrical Patterson function". <i>Acta Crystallogr</i> <b>6</b> (8–9): 678–85.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0365110X53001940" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0365110X53001940</a>.</span></span></li>
<li id="cite_note-NatFranGos-41" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatFranGos_41-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatFranGos_41-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Franklin, Rosalind and Gosling, Raymond (1953).<a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/franklingosling.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Molecular Configuration in Sodium Thymonucleate. Franklin R. and Gosling R.G"</a> (PDF). <i>Nature</i> <b>171</b>(4356): 740–1. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..740F" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..740F</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171740a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171740a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054694" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054694</a>.</span></span></li>
<li id="cite_note-NatWilk-42" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatWilk_42-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatWilk_42-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wilkins M.H.F., A.R. Stokes A.R. & Wilson, H.R. (1953). <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/wilkins.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Molecular Structure of Deoxypentose Nucleic Acids"</a> (PDF). <i>Nature</i> <b>171</b> (4356): 738–740.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..738W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..738W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171738a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171738a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054693" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054693</a>.</span></span></li>
<li id="cite_note-43" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-43" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Leslie AG, Arnott S, Chandrasekaran R, Ratliff RL (1980). "Polymorphism of DNA double helices". <i>J. Mol. Biol.</i> <b>143</b> (1): 49–72. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2F0022-2836%2880%2990124-2" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/0022-2836(80)90124-2</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7441761" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7441761</a>.</span></span></li>
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<li id="cite_note-46" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-46" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Baianu, I.C. (1978). "X-ray scattering by partially disordered membrane systems". <i>Acta Crystallogr A</i> <b>34</b> (5): 751–753. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1978AcCrA..34..751B" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1978AcCrA..34..751B</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0567739478001540" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0567739478001540</a>.</span></span></li>
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<li id="cite_note-50" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-50" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Oh D, Kim Y, Rich A (2002). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139201" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Z-DNA-binding proteins can act as potent effectors of gene expression in vivo"</a>.<i>Proc. Natl. Acad. Sci. U.S.A.</i> <b>99</b> (26): 16666–71.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2002PNAS...9916666O" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2002PNAS...9916666O</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.262672699" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.262672699</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139201" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">139201</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12486233" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12486233</a>.</span></span></li>
<li id="cite_note-arsenic_extremophile-51" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-arsenic_extremophile_51-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-arsenic_extremophile_51-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation news" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://www.bbc.co.uk/news/science-environment-11886943" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Arsenic-loving bacteria may help in hunt for alien life"</a>. <i>BBC News</i>. 2 December 2010<span class="reference-accessdate">. Retrieved 2 December 2010</span>.</span></span></li>
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<li id="cite_note-57" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-57" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wright W, Tesmer V, Huffman K, Levene S, Shay J (1997). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC316649" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Normal human chromosomes have long G-rich telomeric overhangs at one end"</a>. <i>Genes Dev</i> <b>11</b> (21): 2801–9. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1101%2Fgad.11.21.2801" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1101/gad.11.21.2801</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC316649" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">316649</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9353250" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9353250</a>.</span></span></li>
<li id="cite_note-58" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-58" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://ndbserver.rutgers.edu/atlas/xray/structures/U/ud0017/ud0017.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">NDB UD0017</a></span></li>
<li id="cite_note-Burge-59" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Burge_59-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Burge_59-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Burge S, Parkinson G, Hazel P, Todd A, Neidle S (2006). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636468" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Quadruplex DNA: sequence, topology and structure"</a>. <i>Nucleic Acids Res</i> <b>34</b> (19): 5402–15.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fnar%2Fgkl655" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/nar/gkl655</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636468" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1636468</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/17012276" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">17012276</a>.</span></span></li>
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<li id="cite_note-77" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-77" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Beckman KB, Ames BN (1997). "Oxidative decay of DNA". <i>J. Biol. Chem.</i> <b>272</b> (32): 19633–6.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1074%2Fjbc.272.32.19633" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1074/jbc.272.32.19633</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9289489" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9289489</a>.</span></span></li>
<li id="cite_note-78" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-78" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Valerie K, Povirk L (2003). "Regulation and mechanisms of mammalian double-strand break repair". <i>Oncogene</i> <b>22</b>(37): 5792–812. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fsj.onc.1206679" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/sj.onc.1206679</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12947387" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12947387</a>.</span></span></li>
<li id="cite_note-Weinberg-79" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Weinberg_79-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation news" style="word-wrap: break-word;">Johnson, George (28 December 2010). <a rel="nofollow" class="external text" href="http://www.nytimes.com/2010/12/28/health/28cancer.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Unearthing Prehistoric Tumors, and Debate"</a>. <i><a href="http://en.wikipedia.org/wiki/The_New_York_Times" title="The New York Times" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">The New York Times</a></i>. "If we lived long enough, sooner or later we all would get cancer."</span></span></li>
<li id="cite_note-80" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-80" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Alberts, B, Johnson A, Lewis J, et al. (2002). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/books/NBK26897/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The Preventable Causes of Cancer"</a>. <i>Molecular biology of the cell</i> (4th ed.). New York: Garland Science. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-8153-4072-9" title="Special:BookSources/0-8153-4072-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-8153-4072-9</a>. "A certain irreducible background incidence of cancer is to be expected regardless of circumstances: mutations can never be absolutely avoided, because they are an inescapable consequence of fundamental limitations on the accuracy of DNA replication, as discussed in Chapter 5. If a human could live long enough, it is inevitable that at least one of his or her cells would eventually accumulate a set of mutations sufficient for cancer to develop."</span></span></li>
<li id="cite_note-81" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-81" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Bernstein H, Payne CM, Bernstein C, Garewal H, Dvorak K (2008). Cancer and aging as consequences of un-repaired DNA damage. In: New Research on DNA Damages (Editors: Honoka Kimura and Aoi Suzuki) Nova Science Publishers, Inc., New York, Chapter 1, pp. 1-47. open access, but read only<a rel="nofollow" class="external free" href="https://www.novapublishers.com/catalog/product_info.php?products_id=43247" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAdUlEQVQYV2P4//8/Awxv3LThf0dXKxyD+DA5DEUg+tWrV2AaWTFcIboJyJrhCtGtRMcgebhpL2/4/v//Lvn//x+7IRjIfn8v+P/t055gxZgKPzaC8Y/nMYQVLpnM8f/zo3AqKfzyOOL/h/sh/59c9sBUSIyvAeRdJWjk4E//AAAAAElFTkSuQmCC); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">https://www.novapublishers.com/catalog/product_info.php?products_id=43247</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/1604565810" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 1604565810</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/9781604565812" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-1604565812</a></span></li>
<li id="cite_note-82" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-82" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Hoeijmakers JH (October 2009). "DNA damage, aging, and cancer". <i>N. Engl. J. Med.</i> <b>361</b> (15): 1475–85.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1056%2FNEJMra0804615" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1056/NEJMra0804615</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19812404" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19812404</a>.</span></span></li>
<li id="cite_note-83" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-83" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Freitas AA, de Magalhães JP (2011). "A review and appraisal of the DNA damage theory of ageing". <i>Mutat. Res.</i><b>728</b> (1–2): 12–22. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.mrrev.2011.05.001" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.mrrev.2011.05.001</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/21600302" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">21600302</a>.</span></span></li>
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<li id="cite_note-101" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-101" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Jenuwein T, Allis C (2001). "Translating the histone code". <i>Science</i> <b>293</b> (5532): 1074–80.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1126%2Fscience.1063127" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1126/science.1063127</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11498575" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11498575</a>.</span></span></li>
<li id="cite_note-102" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-102" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Ito T (2003). "Nucleosome assembly and remodelling".<i>Curr Top Microbiol Immunol</i>. Current Topics in Microbiology and Immunology <b>274</b>: 1–22. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1007%2F978-3-642-55747-7_1" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1007/978-3-642-55747-7_1</a>. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/978-3-540-44208-0" title="Special:BookSources/978-3-540-44208-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">978-3-540-44208-0</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12596902" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12596902</a>.</span></span></li>
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<li id="cite_note-105" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-105" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Iftode C, Daniely Y, Borowiec J (1999). "Replication protein A (RPA): the eukaryotic SSB". <i>Crit Rev Biochem Mol Biol</i> <b>34</b> (3): 141–80.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1080%2F10409239991209255" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1080/10409239991209255</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10473346" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10473346</a>.</span></span></li>
<li id="cite_note-106" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-106" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=1LMB" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">PDB 1LMB</a></span></li>
<li id="cite_note-107" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-107" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Myers L, Kornberg R (2000). "Mediator of transcriptional regulation". <i>Annu Rev Biochem</i> <b>69</b>: 729–49.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.biochem.69.1.729" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.biochem.69.1.729</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10966474" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10966474</a>.</span></span></li>
<li id="cite_note-108" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-108" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Spiegelman B, Heinrich R (2004). "Biological control through regulated transcriptional coactivators". <i>Cell</i> <b>119</b>(2): 157–67. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.cell.2004.09.037" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.cell.2004.09.037</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15479634" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">15479634</a>.</span></span></li>
<li id="cite_note-109" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-109" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Li Z, Van Calcar S, Qu C, Cavenee W, Zhang M, Ren B (2003). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166200" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells"</a>. <i>Proc Natl Acad Sci USA</i><b>100</b> (14): 8164–9. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2003PNAS..100.8164L" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2003PNAS..100.8164L</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.1332764100" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.1332764100</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166200" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">166200</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12808131" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12808131</a>.</span></span></li>
<li id="cite_note-110" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-110" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=1RVA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">PDB 1RVA</a></span></li>
<li id="cite_note-111" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-111" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Bickle T, Krüger D (1993). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372918" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Biology of DNA restriction"</a>.<i>Microbiol Rev</i> <b>57</b> (2): 434–50. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372918" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">372918</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/8336674" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">8336674</a>.</span></span></li>
<li id="cite_note-Doherty-112" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Doherty_112-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Doherty_112-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Doherty A, Suh S (2000). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113121" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Structural and mechanistic conservation in DNA ligases"</a>. <i>Nucleic Acids Res</i> <b>28</b>(21): 4051–8. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fnar%2F28.21.4051" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/nar/28.21.4051</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113121" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">113121</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11058099" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11058099</a>.</span></span></li>
<li id="cite_note-113" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-113" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Schoeffler A, Berger J (2005). "Recent advances in understanding structure-function relationships in the type II topoisomerase mechanism". <i>Biochem Soc Trans</i> <b>33</b> (Pt 6): 1465–70. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1042%2FBST20051465" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1042/BST20051465</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16246147" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16246147</a>.</span></span></li>
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<li id="cite_note-144" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-144" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Jeffreys A, Wilson V, Thein S (1985). "Individual-specific 'fingerprints' of human DNA". <i>Nature</i> <b>316</b> (6023): 76–9.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1985Natur.316...76J" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1985Natur.316...76J</a>. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F316076a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/316076a0</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/2989708" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2989708</a>.</span></span></li>
<li id="cite_note-145" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-145" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://web.archive.org/web/20061214004903/http://www.forensic.gov.uk/forensic_t/inside/news/list_casefiles.php?case=1" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Colin Pitchfork — first murder conviction on DNA evidence also clears the prime suspect</a> Forensic Science Service Accessed 23 December 2006</span></li>
<li id="cite_note-146" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-146" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation web" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://massfatality.dna.gov/Introduction/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"DNA Identification in Mass Fatality Incidents"</a>. National Institute of Justice. September 2006.</span></span></li>
<li id="cite_note-147" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-147" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Pierre_Baldi" title="Pierre Baldi" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Baldi, Pierre</a>; Brunak, Soren (2001). <i>Bioinformatics: The Machine Learning Approach</i>. MIT Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/978-0-262-02506-5" title="Special:BookSources/978-0-262-02506-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">978-0-262-02506-5</a>. <a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/45951728" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">45951728</a>.</span></span></li>
<li id="cite_note-148" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-148" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Gusfield, Dan. <i>Algorithms on Strings, Trees, and Sequences: Computer Science and Computational Biology</i>.<a href="http://en.wikipedia.org/wiki/Cambridge_University_Press" title="Cambridge University Press" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Cambridge University Press</a>, 15 January 1997. <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780521585194" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-521-58519-4</a>.</span></li>
<li id="cite_note-149" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-149" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Sjölander K (2004). "Phylogenomic inference of protein molecular function: advances and challenges".<i>Bioinformatics</i> <b>20</b> (2): 170–9.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fbioinformatics%2Fbth021" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/bioinformatics/bth021</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/14734307" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">14734307</a>.</span></span></li>
<li id="cite_note-Mount-150" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Mount_150-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Mount DM (2004). <i>Bioinformatics: Sequence and Genome Analysis</i> (2 ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-87969-712-1" title="Special:BookSources/0-87969-712-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-87969-712-1</a>.<a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/55106399" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">55106399</a>.</span></span></li>
<li id="cite_note-151" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-151" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Rothemund PW (2006). "Folding DNA to create nanoscale shapes and patterns". <i>Nature</i> <b>440</b> (7082): 297–302. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2006Natur.440..297R" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2006Natur.440..297R</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature04586" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature04586</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16541064" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16541064</a>.</span></span></li>
<li id="cite_note-152" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-152" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Andersen ES, Dong M, Nielsen MM (2009). "Self-assembly of a nanoscale DNA box with a controllable lid".<i>Nature</i> <b>459</b> (7243): 73–6. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2009Natur.459...73A" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2009Natur.459...73A</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature07971" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature07971</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19424153" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19424153</a>.</span></span></li>
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<li id="cite_note-163" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-163" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Levene P, (1 December 1919). "The structure of yeast nucleic acid". <i>J Biol Chem</i> <b>40</b> (2): 415–24.</span></span></li>
<li id="cite_note-164" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-164" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Astbury W, (1947). "Nucleic acid". <i>Symp. SOC. Exp. Biol.</i> <b>1</b> (66).</span></span></li>
<li id="cite_note-Soyfer-165" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Soyfer_165-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Valery N. Soyfer (2001). "The consequences of political dictatorship for Russian science". <i>Nature Reviews Genetics</i><b>2</b> (9): 723–729. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F35088598" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/35088598</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11533721" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11533721</a>.</span></span></li>
<li id="cite_note-166" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-166" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Lorenz MG, Wackernagel W (1994). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372978" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Bacterial gene transfer by natural genetic transformation in the environment"</a>. <i>Microbiol. Rev.</i> <b>58</b> (3): 563–602.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372978" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">372978</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7968924" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7968924</a>.</span></span></li>
<li id="cite_note-167" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-167" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Avery O, MacLeod C, McCarty M (1944). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135445" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type Iii"</a>. <i>J Exp Med</i> <b>79</b>(2): 137–158. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1084%2Fjem.79.2.137" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1084/jem.79.2.137</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135445" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2135445</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19871359" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19871359</a>.</span></span></li>
<li id="cite_note-168" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-168" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Hershey A, Chase M (1952). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147348" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage"</a>. <i>J Gen Physiol</i> <b>36</b> (1): 39–56.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1085%2Fjgp.36.1.39" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1085/jgp.36.1.39</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147348" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2147348</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12981234" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12981234</a>.</span></span></li>
<li id="cite_note-169" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-169" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">The B-DNA X-ray pattern <a rel="nofollow" class="external text" href="http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/pictures/sci9.001.5.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">on the right of this linked image</a> was obtained by <a href="http://en.wikipedia.org/wiki/Rosalind_Franklin" title="Rosalind Franklin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Rosalind Franklin</a> and <a href="http://en.wikipedia.org/wiki/Raymond_Gosling" title="Raymond Gosling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Raymond Gosling</a> in May 1952 at high hydration levels of DNA and it has been labeled as "Photo 51"</span></li>
<li id="cite_note-NatureDNA50-170" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatureDNA50_170-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Nature Archives <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/archive.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Double Helix of DNA: 50 Years</a></span></li>
<li id="cite_note-171" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-171" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation web" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/pictures/franklin-typeBphoto.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Original X-ray diffraction image"</a>. Osulibrary.oregonstate.edu<span class="reference-accessdate">. Retrieved 6 February 2011</span>.</span></span></li>
<li id="cite_note-172" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-172" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://nobelprize.org/nobel_prizes/medicine/laureates/1962/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">The Nobel Prize in Physiology or Medicine 1962</a>Nobelprize .org Accessed 22 December 06</span></li>
<li id="cite_note-173" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-173" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Brenda Maddox (23 January 2003). <a rel="nofollow" class="external text" href="http://www.biomath.nyu.edu/index/course/hw_articles/nature4.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The double helix and the 'wronged heroine'"</a> (PDF). <i>Nature</i> <b>421</b> (6921): 407–408. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature01399" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature01399</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12540909" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12540909</a>.</span></span></li>
<li id="cite_note-174" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-174" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Crick, F.H.C. <a rel="nofollow" class="external text" href="http://genome.wellcome.ac.uk/assets/wtx030893.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">On degenerate templates and the adaptor hypothesis (PDF).</a> genome.wellcome.ac.uk (Lecture, 1955). Retrieved 22 December 2006.</span></li>
<li id="cite_note-175" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-175" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Meselson M, Stahl F (1958). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528642" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The replication of DNA in Escherichia coli"</a>. <i>Proc Natl Acad Sci USA</i> <b>44</b> (7): 671–82. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1958PNAS...44..671M" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1958PNAS...44..671M</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.44.7.671" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.44.7.671</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528642" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">528642</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16590258" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16590258</a>.</span></span></li>
<li id="cite_note-176" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-176" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://nobelprize.org/nobel_prizes/medicine/laureates/1968/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">The Nobel Prize in Physiology or Medicine 1968</a>Nobelprize.org Accessed 22 December 06</span></li>
</ol>
</div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Further_reading">Further reading</span></h2>
<div class="refbegin references-column-width" style="font-size: 11.199999809265137px; margin-bottom: 0.5em; font-family: sans-serif; line-height: 19.200000762939453px; -webkit-column-width: 30em;">
<ul style="line-height: 1.5em; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=);">
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Berry, Andrew; <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Watson, James</a>. (2003). <i>DNA: the secret of life</i>. New York: Alfred A. Knopf. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-375-41546-7" title="Special:BookSources/0-375-41546-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-375-41546-7</a>.</span></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Calladine, Chris R.; Drew, Horace R.; Luisi, Ben F. and Travers, Andrew A. (2003). <i>Understanding DNA: the molecule & how it works</i>. Amsterdam: Elsevier Academic Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-12-155089-3" title="Special:BookSources/0-12-155089-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-12-155089-3</a>.</span></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Dennis, Carina; Julie Clayton (2003). <i>50 years of DNA</i>. Basingstoke: Palgrave Macmillan. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/1-4039-1479-6" title="Special:BookSources/1-4039-1479-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">1-4039-1479-6</a>.</span></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Horace_Freeland_Judson" title="Horace Freeland Judson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Judson, Horace F</a>. 1979. <i>The Eighth Day of Creation: Makers of the Revolution in Biology</i>. Touchstone Books, <a href="http://en.wikipedia.org/wiki/Special:BookSources/0671225405" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-671-22540-5</a>. 2nd edition: Cold Spring Harbor Laboratory Press, 1996 paperback: <a href="http://en.wikipedia.org/wiki/Special:BookSources/0879694785" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-87969-478-5</a>.</li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Robert_Olby" title="Robert Olby" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Olby, Robert C.</a> (1994). <i>The path to the double helix: the discovery of DNA</i>. New York: Dover Publications. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-486-68117-3" title="Special:BookSources/0-486-68117-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-486-68117-3</a>.</span>, first published in October 1974 by MacMillan, with foreword by Francis Crick;the definitive DNA textbook,revised in 1994 with a 9 page postscript</li>
<li style="margin-bottom: 0.1em;">Micklas, David. 2003. <i>DNA Science: A First Course</i>. Cold Spring Harbor Press: <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780879696368" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-87969-636-8</a></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Matt_Ridley" title="Matt Ridley" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Ridley, Matt</a> (2006). <i>Francis Crick: discoverer of the genetic code</i>. Ashland, OH: Eminent Lives, Atlas Books. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-06-082333-X" title="Special:BookSources/0-06-082333-X" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-06-082333-X</a>.</span></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Olby, Robert C. (2009). <i>Francis Crick: A Biography</i>. Plainview, N.Y: Cold Spring Harbor Laboratory Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-87969-798-9" title="Special:BookSources/0-87969-798-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-87969-798-9</a>.</span></li>
<li style="margin-bottom: 0.1em;">Rosenfeld, Israel. 2010. <i>DNA: A Graphic Guide to the Molecule that Shook the World</i>. Columbia University Press: <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780231142717" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-231-14271-7</a></li>
<li style="margin-bottom: 0.1em;">Schultz, Mark and Zander Cannon. 2009. <i>The Stuff of Life: A Graphic Guide to Genetics and DNA</i>. Hill and Wang: <a href="http://en.wikipedia.org/wiki/Special:BookSources/0809089475" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-8090-8947-5</a></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Gunther_Stent" title="Gunther Stent" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Stent, Gunther Siegmund</a>; Watson, James. (1980). <i><a href="http://en.wikipedia.org/wiki/The_Double_Helix" title="The Double Helix" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">The double helix: a personal account of the discovery of the structure of DNA</a></i>. New York: Norton. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-393-95075-1" title="Special:BookSources/0-393-95075-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-393-95075-1</a>.</span></li>
<li style="margin-bottom: 0.1em;">Watson, James. 2004. <i>DNA: The Secret of Life</i>. Random House: <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780099451846" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-09-945184-6</a></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Maurice_Wilkins" title="Maurice Wilkins" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Wilkins, Maurice</a> (2003). <i>The third man of the double helix the autobiography of Maurice Wilkins</i>. Cambridge, Eng: University Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-19-860665-6" title="Special:BookSources/0-19-860665-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-19-860665-6</a>.</span></li>
</ul>
</div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="External_links">External links</span></h2>
<table class="vertical-navbox nowraplinks infobox bordered" cellspacing="5" cellpadding="0" style="border-style: solid; border-color: rgb(170, 170, 170); font-size: 11.199999809265137px; background-color: rgb(249, 249, 249); color: rgb(0, 0, 0); margin: 0px 0px 1em 1em; padding: 0.2em; float: right; clear: right; text-align: center; line-height: 1.4em; border-collapse: collapse; font-family: sans-serif; width: auto; border-spacing: 0.4em 0px;">
<tbody>
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<th style="border-style: solid; border-color: rgb(170, 170, 170); vertical-align: top; padding: 0.2em 0.4em; line-height: 1.2em; background-color: rgb(239, 239, 239); font-size: 1em;">Library resources</th>
</tr>
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<th style="border-style: solid; border-color: rgb(170, 170, 170); vertical-align: top; padding: 0.1em;">About DNA</th>
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<tr>
<td class="plainlist" style="border-style: solid; border-color: rgb(170, 170, 170); vertical-align: top; padding: 0px 0.1em 0.4em;">
<ul style="line-height: inherit; list-style: none none; margin: 0px; padding: 0px;">
<li style="margin-bottom: 0px;"><a class="external text" href="http://tools.wmflabs.org/ftl/cgi-bin/ftl?st=&su=DNA&library=OLBP" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); white-space: nowrap; padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Online books</a></li>
<li style="margin-bottom: 0px;"><a class="external text" href="http://tools.wmflabs.org/ftl/cgi-bin/ftl?st=&su=DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); white-space: nowrap; padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Resources in your library</a></li>
<li style="margin-bottom: 0px;"><a class="external text" href="http://tools.wmflabs.org/ftl/cgi-bin/ftl?st=&su=DNA&library=0CHOOSE0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); white-space: nowrap; padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Resources in other libraries</a></li>
</ul>
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<td class="mbox-text plainlist" style="border: none; padding: 0.25em 0.9em; width: 161.3249969482422px;">Wikiquote has a collection of quotations related to: <i><b><a href="http://en.wikiquote.org/wiki/Special:Search/DNA" class="extiw" title="q:Special:Search/DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: none !important; padding: 0px !important;">DNA</a></b></i></td>
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<div style="text-align: center; white-space: nowrap;"><b>Listen to this article</b> (<a href="http://en.wikipedia.org/wiki/File:Dna.ogg" title="File:Dna.ogg" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none !important; padding: 0px !important;">info/dl</a>)
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<div style="font-size: xx-small; line-height: 1.6em; margin-left: 60px;">This audio file was created from a revision of the "<span class="fn">DNA</span>" article dated 2007-02-12, and does not reflect subsequent edits to the article. (<a href="http://en.wikipedia.org/wiki/Wikipedia:Media_help" title="Wikipedia:Media help" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none !important; padding: 0px !important;">Audio help</a>)</div>
<div style="text-align: center; clear: both;"><b><a href="http://en.wikipedia.org/wiki/Wikipedia:Spoken_articles" title="Wikipedia:Spoken articles" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none !important; padding: 0px !important;">More spoken articles</a></b></div>
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<ul style="line-height: 19.200000762939453px; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=); font-family: sans-serif; font-size: 12.800000190734863px;">
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.dmoz.org/Science/Biology/Biochemistry_and_Molecular_Biology/Biomolecules/Nucleic_Acids/DNA//" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA</a> at the <a href="http://en.wikipedia.org/wiki/Open_Directory_Project" title="Open Directory Project" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Open Directory Project</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://pipe.scs.fsu.edu/displar.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA binding site prediction on protein</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://nobelprize.org/educational_games/medicine/dna_double_helix/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA the Double Helix Game</a> From the official Nobel Prize web site</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.fidelitysystems.com/Unlinked_DNA.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA under electron microscope</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.dnalc.org/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Dolan DNA Learning Center</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/archive.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Double Helix: 50 years of DNA</a>, <i><a href="http://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nature</a></i></li>
<li style="margin-bottom: 0.1em;"><i><a href="http://en.wikipedia.org/wiki/Proteopedia" title="Proteopedia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA</a></i></li>
<li style="margin-bottom: 0.1em;"><i><a href="http://en.wikipedia.org/wiki/Proteopedia" title="Proteopedia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/Forms_of_DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Forms_of_DNA</a></i></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nature.com/encode/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">ENCODE threads explorer</a> ENCODE Home page. <a href="http://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nature (journal)</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.ncbe.reading.ac.uk/DNA50/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Double Helix 1953–2003</a> National Centre for Biotechnology Education</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.genome.gov/10506718" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Genetic Education Modules for Teachers</a>—<i>DNA from the Beginning</i> Study Guide</li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Protein_Data_Bank" title="Protein Data Bank" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PDB Molecule of the Month</a> <i><a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb23_1.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">pdb23_1</a></i></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://mason.gmu.edu/~emoody/rfranklin.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Rosalind Franklin's contributions to the study of DNA</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.genome.gov/10506367" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">U.S. National DNA Day</a>—watch videos and participate in real-time chat with top scientists</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nytimes.com/packages/pdf/science/dna-article.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Clue to chemistry of heredity found</a> <a href="http://en.wikipedia.org/wiki/The_New_York_Times" title="The New York Times" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">The New York Times</a> June 1953. First American newspaper coverage of the discovery of the DNA structure</li>
<li style="margin-bottom: 0.1em;"><span class="citation journal" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Robert_Olby" title="Robert Olby" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Olby R</a> (2003). "Quiet debut for the double helix". <i>Nature</i> <b>421</b> (6921): 402–5. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature01397" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature01397</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12540907" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12540907</a>.</span></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.dnaftb.org/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA from the Beginning</a> Another DNA Learning Center site on DNA, genes, and heredity from Mendel to the human genome project.</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://orpheus.ucsd.edu/speccoll/testing/html/mss0660a.html#abstract" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">The Register of Francis Crick Personal Papers 1938 – 2007</a> at Mandeville Special Collections Library, <a href="http://en.wikipedia.org/wiki/University_of_California,_San_Diego" title="University of California, San Diego" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">University of California, San Diego</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nature.com/polopoly_fs/7.9746!/file/Crick%20letter%20to%20Michael.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Seven-page, handwritten letter that Crick sent to his 12-year-old son Michael in 1953 describing the structure of DNA.</a> See <a rel="nofollow" class="external text" href="http://www.nature.com/news/crick-s-medal-goes-under-the-hammer-1.12705" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Crick’s medal goes under the hammer</a>, Nature, 5 April 2013.</li>
</ul>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The two strands of DNA run in opposite directions to each other and are therefore <a href="http://en.wikipedia.org/wiki/Antiparallel_(biochemistry)" title="Antiparallel (biochemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">anti-parallel</a>, one backbone being 3′ (three prime) and the other 5′ (five prime). This refers to the direction the 3rd and 5th carbon on the sugar molecule is facing. Attached to each sugar is one of four types of molecules called nucleobases (informally, <i>bases</i>). It is the<a href="http://en.wikipedia.org/wiki/Nucleic_acid_sequence" title="Nucleic acid sequence" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sequence</a> of these four nucleobases along the backbone that encodes genetic information. This information is read using the <a href="http://en.wikipedia.org/wiki/Genetic_code" title="Genetic code" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic code</a>, which specifies the sequence of the <a href="http://en.wikipedia.org/wiki/Amino_acid" title="Amino acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">amino acids</a> within proteins. The code is read by copying stretches of DNA into the related <a href="http://en.wikipedia.org/wiki/Nucleic_acid" title="Nucleic acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleic acid</a> RNA in a process called <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" title="Transcription (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription</a>.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Within cells, DNA is organized into long structures called <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomes</a>. During <a href="http://en.wikipedia.org/wiki/Cell_division" title="Cell division" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell division</a> these chromosomes are duplicated in the process of <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a>, providing each cell its own complete set of chromosomes. <a href="http://en.wikipedia.org/wiki/Eukaryote" title="Eukaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Eukaryotic organisms</a> (<a href="http://en.wikipedia.org/wiki/Animal" title="Animal" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">animals</a>, <a href="http://en.wikipedia.org/wiki/Plant" title="Plant" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">plants</a>, <a href="http://en.wikipedia.org/wiki/Fungus" title="Fungus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">fungi</a>, and <a href="http://en.wikipedia.org/wiki/Protist" title="Protist" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protists</a>) store most of their DNA inside the <a href="http://en.wikipedia.org/wiki/Cell_nucleus" title="Cell nucleus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell nucleus</a> and some of their DNA in<a href="http://en.wikipedia.org/wiki/Organelle" title="Organelle" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">organelles</a>, such as <a href="http://en.wikipedia.org/wiki/Mitochondria" title="Mitochondria" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mitochondria</a> or <a href="http://en.wikipedia.org/wiki/Chloroplasts" title="Chloroplasts" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chloroplasts</a>.<sup id="cite_ref-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[1]</a></sup> In contrast, <a href="http://en.wikipedia.org/wiki/Prokaryote" title="Prokaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">prokaryotes</a> (<a href="http://en.wikipedia.org/wiki/Bacteria" title="Bacteria" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacteria</a> and <a href="http://en.wikipedia.org/wiki/Archaea" title="Archaea" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">archaea</a>) store their DNA only in the <a href="http://en.wikipedia.org/wiki/Cytoplasm" title="Cytoplasm" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytoplasm</a>. Within the chromosomes, <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromatin</a> proteins such as <a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histones</a> compact and organize DNA. These compact structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The obsolete synonym "<b>desoxyribonucleic acid</b>" may occasionally be encountered, for example, in pre-1953 genetics.</p>
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Chemical structure of DNA. <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Hydrogen bonds</a> shown as dotted lines.</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA is a long <a href="http://en.wikipedia.org/wiki/Polymer" title="Polymer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polymer</a> made from repeating units called <a href="http://en.wikipedia.org/wiki/Nucleotide" title="Nucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleotides</a>.<sup id="cite_ref-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[2]</a></sup><sup id="cite_ref-Alberts_3-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Alberts-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[3]</a></sup><sup id="cite_ref-Butler_4-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Butler-4" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[4]</a></sup> DNA was first identified and isolated by <a href="http://en.wikipedia.org/wiki/Friedrich_Miescher" title="Friedrich Miescher" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Friedrich Miescher</a> and the double helix structure of DNA was first discovered by <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">James Watson</a> and <a href="http://en.wikipedia.org/wiki/Francis_Crick" title="Francis Crick" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Francis Crick</a>. The structure of DNA of all species comprises two helical chains each coiled round the same axis, and each with a pitch of 34 <a href="http://en.wikipedia.org/wiki/%C3%85ngstr%C3%B6m" title="Ångström" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ångströms</a> (3.4 <a href="http://en.wikipedia.org/wiki/Nanometre" title="Nanometre" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanometres</a>) and a radius of 10 ångströms (1.0 <a href="http://en.wikipedia.org/wiki/Nanometre" title="Nanometre" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanometres</a>).<sup id="cite_ref-FWPUB_5-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-FWPUB-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[5]</a></sup> According to another study, when measured in a particular solution, the DNA chain measured 22 to 26 <a href="http://en.wikipedia.org/wiki/%C3%85ngstr%C3%B6m" title="Ångström" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ångströms</a> wide (2.2 to 2.6 <a href="http://en.wikipedia.org/wiki/Nanometre" title="Nanometre" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanometres</a>), and one nucleotide unit measured 3.3 Å (0.33 nm) long.<sup id="cite_ref-6" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[6]</a></sup> Although each individual repeating unit is very small, DNA polymers can be very large molecules containing millions of nucleotides. For instance, the largest human <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosome</a>, chromosome <a href="http://en.wikipedia.org/wiki/Chromosome_1_(human)" title="Chromosome 1 (human)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">number 1</a>, consists of approximately 220 million <a href="http://en.wikipedia.org/wiki/Base_pair" title="Base pair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">base pairs</a><sup id="cite_ref-7" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[7]</a></sup> and is 85 mm long.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In living organisms DNA does not usually exist as a single molecule, but instead as a pair of molecules that are held tightly together.<sup id="cite_ref-autogenerated2_8-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-autogenerated2-8" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[8]</a></sup><sup id="cite_ref-berg_9-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-berg-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[9]</a></sup> These two long strands entwine like vines, in the shape of a <a href="http://en.wikipedia.org/wiki/Double_helix" title="Double helix" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">double helix</a>. The nucleotide repeats contain both the segment of the backbone of the molecule, which holds the chain together, and a nucleobase, which interacts with the other DNA strand in the helix. A nucleobase linked to a sugar is called a <a href="http://en.wikipedia.org/wiki/Nucleoside" title="Nucleoside" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoside</a> and a base linked to a sugar and one or more phosphate groups is called a <a href="http://en.wikipedia.org/wiki/Nucleotide" title="Nucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleotide</a>. A polymer comprising multiple linked nucleotides (as in DNA) is called a <a href="http://en.wikipedia.org/wiki/Polynucleotide" title="Polynucleotide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polynucleotide</a>.<sup id="cite_ref-IUPAC_10-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-IUPAC-10" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[10]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The backbone of the DNA strand is made from alternating <a href="http://en.wikipedia.org/wiki/Phosphate" title="Phosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphate</a> and <a href="http://en.wikipedia.org/wiki/Carbohydrate" title="Carbohydrate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sugar</a> residues.<sup id="cite_ref-Ghosh_11-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Ghosh-11" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[11]</a></sup> The sugar in DNA is <a href="http://en.wikipedia.org/wiki/Deoxyribose" title="Deoxyribose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">2-deoxyribose</a>, which is a<a href="http://en.wikipedia.org/wiki/Pentose" title="Pentose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">pentose</a> (five-<a href="http://en.wikipedia.org/wiki/Carbon" title="Carbon" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">carbon</a>) sugar. The sugars are joined together by phosphate groups that form <a href="http://en.wikipedia.org/wiki/Phosphodiester_bond" title="Phosphodiester bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphodiester bonds</a> between the third and fifth carbon <a href="http://en.wikipedia.org/wiki/Atom" title="Atom" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">atoms</a> of adjacent sugar rings. These asymmetric <a href="http://en.wikipedia.org/wiki/Covalent_bond" title="Covalent bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bonds</a> mean a strand of DNA has a direction. In a double helix the direction of the nucleotides in one strand is opposite to their direction in the other strand: the strands are<i>antiparallel</i>. The asymmetric ends of DNA strands are called the <a href="http://en.wikipedia.org/wiki/Directionality_(molecular_biology)" title="Directionality (molecular biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5′</a> (<i>five prime</i>) and <a href="http://en.wikipedia.org/wiki/Directionality_(molecular_biology)" title="Directionality (molecular biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">3′</a> (<i>three prime</i>) ends, with the 5′ end having a terminal phosphate group and the 3′ end a terminal hydroxyl group. One major difference between DNA and RNA is the sugar, with the 2-deoxyribose in DNA being replaced by the alternative pentose sugar <a href="http://en.wikipedia.org/wiki/Ribose" title="Ribose" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ribose</a> in RNA.<sup id="cite_ref-berg_9-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-berg-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[9]</a></sup></p>
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A section of DNA. The bases lie horizontally between the two spiraling strands.<sup id="cite_ref-12" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-12" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[12]</a></sup>(<a href="http://en.wikipedia.org/wiki/File:DNA_orbit_animated.gif" title="File:DNA orbit animated.gif" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">animated version</a>).</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The DNA double helix is stabilized primarily by two forces: <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen bonds</a> between nucleotides and <a href="http://en.wikipedia.org/wiki/Stacking_(chemistry)" title="Stacking (chemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">base-stacking</a> interactions among <a href="http://en.wikipedia.org/wiki/Aromatic" title="Aromatic" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aromatic</a> nucleobases.<sup id="cite_ref-Yakovchuk2006_13-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Yakovchuk2006-13" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[13]</a></sup> In the aqueous environment of the cell, the conjugated <a href="http://en.wikipedia.org/wiki/Pi_bond" title="Pi bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">π bonds</a> of nucleotide bases align perpendicular to the axis of the DNA molecule, minimizing their interaction with the <a href="http://en.wikipedia.org/wiki/Solvation_shell" title="Solvation shell" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">solvation shell</a> and therefore, the <a href="http://en.wikipedia.org/wiki/Gibbs_free_energy" title="Gibbs free energy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Gibbs free energy</a>. The four bases found in DNA are <a href="http://en.wikipedia.org/wiki/Adenine" title="Adenine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenine</a> (abbreviated A), <a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a> (C), <a href="http://en.wikipedia.org/wiki/Guanine" title="Guanine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">guanine</a> (G) and <a href="http://en.wikipedia.org/wiki/Thymine" title="Thymine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine</a> (T). These four bases are attached to the sugar/phosphate to form the complete nucleotide, as shown for <a href="http://en.wikipedia.org/wiki/Adenosine_monophosphate" title="Adenosine monophosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenosine monophosphate</a>.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Nucleobase_classification">Nucleobase classification</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The nucleobases are classified into two types: the <a href="http://en.wikipedia.org/wiki/Purine" title="Purine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">purines</a>, A and G, being fused five- and six-membered <a href="http://en.wikipedia.org/wiki/Heterocyclic_compound" title="Heterocyclic compound" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">heterocyclic compounds</a>, and the <a href="http://en.wikipedia.org/wiki/Pyrimidine" title="Pyrimidine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">pyrimidines</a>, the six-membered rings C and T.<sup id="cite_ref-berg_9-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-berg-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[9]</a></sup> A fifth pyrimidine nucleobase, <a href="http://en.wikipedia.org/wiki/Uracil" title="Uracil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">uracil</a> (U), usually takes the place of thymine in RNA and differs from thymine by lacking a <a href="http://en.wikipedia.org/wiki/Methyl_group" title="Methyl group" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methyl group</a> on its ring. In addition to RNA and DNA a large number of artificial <a href="http://en.wikipedia.org/wiki/Nucleic_acid_analogues" title="Nucleic acid analogues" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleic acid analogues</a> have also been created to study the properties of nucleic acids, or for use in biotechnology.<sup id="cite_ref-14" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-14" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[14]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Uracil is not usually found in DNA, occurring only as a breakdown product of cytosine. However in a number of bacteriophages – <i>Bacillus subtilis</i> bacteriophages PBS1 and PBS2 and <i>Yersinia</i> bacteriophage piR1-37 – thymine has been replaced by uracil.<sup id="cite_ref-Kiljunen2005_15-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Kiljunen2005-15" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[15]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Base_J" title="Base J" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Base J</a> (beta-d-glucopyranosyloxymethyluracil), a modified form of uracil, is also found in a number of organisms: the flagellates <i><a href="http://en.wikipedia.org/w/index.php?title=Diplonema_(protozoa)&action=edit&redlink=1" class="new" title="Diplonema (protozoa) (page does not exist)" style="text-decoration: none; color: rgb(165, 88, 88); background-image: none;">Diplonema</a></i> and<i><a href="http://en.wikipedia.org/wiki/Euglena" title="Euglena" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Euglena</a></i>, and all the <a href="http://en.wikipedia.org/wiki/Kinetoplastid" title="Kinetoplastid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">kinetoplastid</a> genera<sup id="cite_ref-Simpson1998_16-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Simpson1998-16" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[16]</a></sup> Biosynthesis of J occurs in two steps: in the first step a specific thymidine in DNA is converted into hydroxymethyldeoxyuridine; in the second HOMedU is glycosylated to form J.<sup id="cite_ref-Borst2008_17-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Borst2008-17" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[17]</a></sup> Proteins that bind specifically to this base have been identified.<sup id="cite_ref-Cross1999_18-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Cross1999-18" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[18]</a></sup><sup id="cite_ref-DiPaolo2005_19-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-DiPaolo2005-19" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[19]</a></sup><sup id="cite_ref-Vainio2009_20-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Vainio2009-20" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[20]</a></sup> These proteins appear to be distant relatives of the Tet1 oncogene that is involved in the pathogenesis of <a href="http://en.wikipedia.org/wiki/Acute_myeloid_leukemia" title="Acute myeloid leukemia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">acute myeloid leukemia</a>.<sup id="cite_ref-Iyer2009_21-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Iyer2009-21" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[21]</a></sup> J appears to act as a termination signal for <a href="http://en.wikipedia.org/wiki/RNA_polymerase_II" title="RNA polymerase II" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase II</a>.<sup id="cite_ref-van_Luenen2012_22-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-van_Luenen2012-22" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[22]</a></sup><sup id="cite_ref-Hazelbaker2012_23-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Hazelbaker2012-23" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[23]</a></sup></p>
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Major and minor grooves of DNA. Minor groove is a binding site for the dye <a href="http://en.wikipedia.org/wiki/Hoechst_stain" title="Hoechst stain" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Hoechst 33258</a>.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Grooves">Grooves</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Twin helical strands form the DNA backbone. Another double helix may be found tracing the spaces, or grooves, between the strands. These voids are adjacent to the base pairs and may provide a <a href="http://en.wikipedia.org/wiki/Binding_site" title="Binding site" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">binding site</a>. As the strands are not symmetrically located with respect to each other, the grooves are unequally sized. One groove, the major groove, is 22 Å wide and the other, the minor groove, is 12 Å wide.<sup id="cite_ref-24" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-24" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[24]</a></sup> The narrowness of the minor groove means that the edges of the bases are more accessible in the major groove. As a result, proteins like <a href="http://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription factors</a> that can bind to specific sequences in double-stranded DNA usually make contacts to the sides of the bases exposed in the major groove.<sup id="cite_ref-Pabo1984_25-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Pabo1984-25" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[25]</a></sup> This situation varies in unusual conformations of DNA within the cell <i>(see below)</i>, but the major and minor grooves are always named to reflect the differences in size that would be seen if the DNA is twisted back into the ordinary B form.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Base_pairing">Base pairing</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Base_pair" title="Base pair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Base pair</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In a DNA double helix, each type of nucleobase on one strand bonds with just one type of nucleobase on the other strand. This is called complementary <a href="http://en.wikipedia.org/wiki/Base_pair" title="Base pair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">base pairing</a>. Here, purines form <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen bonds</a> to pyrimidines, with adenine bonding only to thymine in two hydrogen bonds, and cytosine bonding only to guanine in three hydrogen bonds. This arrangement of two nucleotides binding together across the double helix is called a base pair. As hydrogen bonds are not <a href="http://en.wikipedia.org/wiki/Covalent_bond" title="Covalent bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">covalent</a>, they can be broken and rejoined relatively easily. The two strands of DNA in a double helix can therefore be pulled apart like a zipper, either by a mechanical force or high <a href="http://en.wikipedia.org/wiki/Temperature" title="Temperature" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">temperature</a>.<sup id="cite_ref-26" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-26" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[26]</a></sup> As a result of this complementarity, all the information in the double-stranded sequence of a DNA helix is duplicated on each strand, which is vital in DNA replication. Indeed, this reversible and specific interaction between complementary base pairs is critical for all the functions of DNA in living organisms.<sup id="cite_ref-Alberts_3-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Alberts-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[3]</a></sup></p>
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<td><a href="http://en.wikipedia.org/wiki/File:GC_DNA_base_pair.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="GC DNA base pair.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GC_DNA_base_pair.svg/282px-GC_DNA_base_pair.svg.png" width="282" height="177" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GC_DNA_base_pair.svg/423px-GC_DNA_base_pair.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d7/GC_DNA_base_pair.svg/564px-GC_DNA_base_pair.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<td><a href="http://en.wikipedia.org/wiki/File:AT_DNA_base_pair.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="AT DNA base pair.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/9/91/AT_DNA_base_pair.svg/282px-AT_DNA_base_pair.svg.png" width="282" height="151" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/AT_DNA_base_pair.svg/423px-AT_DNA_base_pair.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/91/AT_DNA_base_pair.svg/564px-AT_DNA_base_pair.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; font-size: 12px; padding: 3px !important;">Top, a <b>GC</b> base pair with three <a href="http://en.wikipedia.org/wiki/Hydrogen_bond" title="Hydrogen bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen bonds</a>. Bottom, an <b>AT</b> base pair with two hydrogen bonds. Non-covalent hydrogen bonds between the pairs are shown as dashed lines.</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The two types of base pairs form different numbers of hydrogen bonds, AT forming two hydrogen bonds, and GC forming three hydrogen bonds (see figures, right). DNA with high <a href="http://en.wikipedia.org/wiki/GC-content" title="GC-content" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">GC-content</a> is more stable than DNA with low GC-content.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">As noted above, most DNA molecules are actually two polymer strands, bound together in a helical fashion by noncovalent bonds; this double stranded structure (<b>dsDNA</b>) is maintained largely by the intrastrand base stacking interactions, which are strongest for G,C stacks. The two strands can come apart – a process known as melting – to form two single-stranded DNA molecules (<b>ssDNA</b>) molecules. Melting occurs at high temperature, low salt and high pH (low pH also melts DNA, but since DNA is unstable due to acid depurination, low pH is rarely used).</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The stability of the dsDNA form depends not only on the GC-content (% G,C basepairs) but also on sequence (since stacking is sequence specific) and also length (longer molecules are more stable). The stability can be measured in various ways; a common way is the "melting temperature", which is the temperature at which 50% of the ds molecules are converted to ss molecules; melting temperature is dependent on ionic strength and the concentration of DNA. As a result, it is both the percentage of GC base pairs and the overall length of a DNA double helix that determines the strength of the association between the two strands of DNA. Long DNA helices with a high GC-content have stronger-interacting strands, while short helices with high AT content have weaker-interacting strands.<sup id="cite_ref-27" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-27" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[27]</a></sup> In biology, parts of the DNA double helix that need to separate easily, such as the TATAAT <a href="http://en.wikipedia.org/wiki/Pribnow_box" title="Pribnow box" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Pribnow box</a> in some <a href="http://en.wikipedia.org/wiki/Promoter_(biology)" title="Promoter (biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">promoters</a>, tend to have a high AT content, making the strands easier to pull apart.<sup id="cite_ref-28" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-28" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[28]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In the laboratory, the strength of this interaction can be measured by finding the temperature necessary to break the hydrogen bonds, their <a href="http://en.wikipedia.org/wiki/DNA_melting" title="DNA melting" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">melting temperature</a> (also called <i>T<sub style="line-height: 1em;">m</sub></i> value). When all the base pairs in a DNA double helix melt, the strands separate and exist in solution as two entirely independent molecules. These single-stranded DNA molecules (<i>ssDNA</i>) have no single common shape, but some conformations are more stable than others.<sup id="cite_ref-29" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-29" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[29]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Sense_and_antisense">Sense and antisense</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Sense_(molecular_biology)" title="Sense (molecular biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Sense (molecular biology)</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A DNA sequence is called "sense" if its sequence is the same as that of a <a href="http://en.wikipedia.org/wiki/Messenger_RNA" title="Messenger RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">messenger RNA</a> copy that is translated into protein.<sup id="cite_ref-30" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-30" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[30]</a></sup> The sequence on the opposite strand is called the "antisense" sequence. Both sense and antisense sequences can exist on different parts of the same strand of DNA (i.e. both strands contain both sense and antisense sequences). In both prokaryotes and eukaryotes, antisense RNA sequences are produced, but the functions of these RNAs are not entirely clear.<sup id="cite_ref-31" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-31" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[31]</a></sup> One proposal is that antisense RNAs are involved in regulating <a href="http://en.wikipedia.org/wiki/Gene_expression" title="Gene expression" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene expression</a> through RNA-RNA base pairing.<sup id="cite_ref-32" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-32" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[32]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A few DNA sequences in prokaryotes and eukaryotes, and more in <a href="http://en.wikipedia.org/wiki/Plasmid" title="Plasmid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">plasmids</a> and <a href="http://en.wikipedia.org/wiki/Virus" title="Virus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viruses</a>, blur the distinction between sense and antisense strands by having <a href="http://en.wikipedia.org/wiki/Overlapping_gene" title="Overlapping gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">overlapping genes</a>.<sup id="cite_ref-33" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-33" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[33]</a></sup> In these cases, some DNA sequences do double duty, encoding one protein when read along one strand, and a second protein when read in the opposite direction along the other strand. In <a href="http://en.wikipedia.org/wiki/Bacteria" title="Bacteria" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacteria</a>, this overlap may be involved in the regulation of gene transcription,<sup id="cite_ref-34" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-34" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[34]</a></sup> while in viruses, overlapping genes increase the amount of information that can be encoded within the small viral genome.<sup id="cite_ref-35" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-35" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[35]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Supercoiling">Supercoiling</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_supercoil" title="DNA supercoil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA supercoil</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA can be twisted like a rope in a process called <a href="http://en.wikipedia.org/wiki/DNA_supercoil" title="DNA supercoil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA supercoiling</a>. With DNA in its "relaxed" state, a strand usually circles the axis of the double helix once every 10.4 base pairs, but if the DNA is twisted the strands become more tightly or more loosely wound.<sup id="cite_ref-36" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-36" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[36]</a></sup> If the DNA is twisted in the direction of the helix, this is positive supercoiling, and the bases are held more tightly together. If they are twisted in the opposite direction, this is negative supercoiling, and the bases come apart more easily. In nature, most DNA has slight negative supercoiling that is introduced by <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> called <a href="http://en.wikipedia.org/wiki/Topoisomerase" title="Topoisomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">topoisomerases</a>.<sup id="cite_ref-Champoux_37-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Champoux-37" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[37]</a></sup> These enzymes are also needed to relieve the twisting stresses introduced into DNA strands during processes such as <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" title="Transcription (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription</a> and <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a>.<sup id="cite_ref-Wang_38-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Wang-38" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[38]</a></sup></p>
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From left to right, the structures of A, B and Z DNA</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Alternate_DNA_structures">Alternate DNA structures</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Molecular_Structure_of_Nucleic_Acids:_A_Structure_for_Deoxyribose_Nucleic_Acid" title="Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid</a>, <a href="http://en.wikipedia.org/wiki/Molecular_models_of_DNA" title="Molecular models of DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular models of DNA</a>, and<a href="http://en.wikipedia.org/wiki/DNA_structure" title="DNA structure" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA structure</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA exists in many possible <a href="http://en.wikipedia.org/wiki/Conformational_isomerism" title="Conformational isomerism" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">conformations</a> that include <a href="http://en.wikipedia.org/wiki/A-DNA" title="A-DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">A-DNA</a>, B-DNA, and <a href="http://en.wikipedia.org/wiki/Z-DNA" title="Z-DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Z-DNA</a> forms, although, only B-DNA and Z-DNA have been directly observed in functional organisms.<sup id="cite_ref-Ghosh_11-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Ghosh-11" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[11]</a></sup> The conformation that DNA adopts depends on the hydration level, DNA sequence, the amount and direction of supercoiling, chemical modifications of the bases, the type and concentration of metal <a href="http://en.wikipedia.org/wiki/Ion" title="Ion" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ions</a>, as well as the presence of<a href="http://en.wikipedia.org/wiki/Polyamine" title="Polyamine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polyamines</a> in solution.<sup id="cite_ref-39" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-39" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[39]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The first published reports of A-DNA <a href="http://en.wikipedia.org/wiki/X-ray_scattering_techniques" title="X-ray scattering techniques" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-ray diffraction patterns</a> — and also B-DNA — used analyses based on <a href="http://en.wikipedia.org/wiki/Patterson_function" title="Patterson function" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Patterson transforms</a> that provided only a limited amount of structural information for oriented fibers of DNA.<sup id="cite_ref-40" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-40" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[40]</a></sup><sup id="cite_ref-NatFranGos_41-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatFranGos-41" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[41]</a></sup> An alternate analysis was then proposed by Wilkins<i>et al.</i>, in 1953, for the <i>in vivo</i> B-DNA X-ray diffraction/scattering patterns of highly hydrated DNA fibers in terms of squares of <a href="http://en.wikipedia.org/wiki/Bessel_function" title="Bessel function" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bessel functions</a>.<sup id="cite_ref-NatWilk_42-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatWilk-42" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[42]</a></sup> In the same journal, <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">James Watson</a> and <a href="http://en.wikipedia.org/wiki/Francis_Crick" title="Francis Crick" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Francis Crick</a> presented their <a href="http://en.wikipedia.org/wiki/Molecular_models_of_DNA" title="Molecular models of DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular modeling</a> analysis of the DNA X-ray diffraction patterns to suggest that the structure was a double-helix.<sup id="cite_ref-FWPUB_5-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-FWPUB-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[5]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Although the "B-DNA form" is most common under the conditions found in cells,<sup id="cite_ref-43" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-43" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[43]</a></sup> it is not a well-defined conformation but a family of related DNA conformations<sup id="cite_ref-44" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-44" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[44]</a></sup> that occur at the high hydration levels present in living cells. Their corresponding X-ray diffraction and scattering patterns are characteristic of molecular <a href="http://en.wikipedia.org/wiki/Paracrystalline" title="Paracrystalline" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">paracrystals</a> with a significant degree of disorder.<sup id="cite_ref-45" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-45" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[45]</a></sup><sup id="cite_ref-46" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-46" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[46]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Compared to B-DNA, the A-DNA form is a wider right-handed spiral, with a shallow, wide minor groove and a narrower, deeper major groove. The A form occurs under non-physiological conditions in partially dehydrated samples of DNA, while in the cell it may be produced in hybrid pairings of DNA and RNA strands, as well as in enzyme-DNA complexes.<sup id="cite_ref-47" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-47" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[47]</a></sup><sup id="cite_ref-48" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-48" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[48]</a></sup>Segments of DNA where the bases have been chemically modified by <a href="http://en.wikipedia.org/wiki/Methylation" title="Methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methylation</a> may undergo a larger change in conformation and adopt the <a href="http://en.wikipedia.org/wiki/Z-DNA" title="Z-DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Z form</a>. Here, the strands turn about the helical axis in a <a href="http://en.wikipedia.org/wiki/Left-handed" title="Left-handed" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">left-handed</a> spiral, the opposite of the more common B form.<sup id="cite_ref-49" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-49" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[49]</a></sup> These unusual structures can be recognized by specific Z-DNA binding proteins and may be involved in the regulation of transcription.<sup id="cite_ref-50" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-50" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[50]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Alternate_DNA_chemistry">Alternate DNA chemistry</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">For a number of years exobiologists have proposed the existence of a <a href="http://en.wikipedia.org/wiki/Shadow_biosphere" title="Shadow biosphere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">shadow biosphere</a>, a postulated microbial biosphere of Earth that uses radically different biochemical and molecular processes than currently known life. One of the proposals was the existence of lifeforms that use <a href="http://en.wikipedia.org/wiki/Arsenic_DNA" title="Arsenic DNA" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">arsenic instead of phosphorus in DNA</a>. A report in 2010 of the possibility in the <a href="http://en.wikipedia.org/wiki/Bacterium" title="Bacterium" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacterium</a> <a href="http://en.wikipedia.org/wiki/GFAJ-1" title="GFAJ-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">GFAJ-1</a>, was announced,<sup id="cite_ref-arsenic_extremophile_51-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-arsenic_extremophile-51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[51]</a></sup><sup id="cite_ref-arsenic_extremophile_51-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-arsenic_extremophile-51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[51]</a></sup><sup id="cite_ref-Space_52-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Space-52" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[52]</a></sup> though the research was disputed,<sup id="cite_ref-Space_52-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Space-52" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[52]</a></sup><sup id="cite_ref-53" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-53" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[53]</a></sup> and evidence suggests the bacterium actively prevents the incorporation of arsenic into the DNA backbone and other biomolecules.<sup id="cite_ref-Nature_54-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nature-54" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[54]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Quadruplex_structures">Quadruplex structures</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/G-quadruplex" title="G-quadruplex" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">G-quadruplex</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">At the ends of the linear chromosomes are specialized regions of DNA called <a href="http://en.wikipedia.org/wiki/Telomere" title="Telomere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomeres</a>. The main function of these regions is to allow the cell to replicate chromosome ends using the enzyme <a href="http://en.wikipedia.org/wiki/Telomerase" title="Telomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomerase</a>, as the enzymes that normally replicate DNA cannot copy the extreme 3′ ends of chromosomes.<sup id="cite_ref-Greider_55-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Greider-55" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[55]</a></sup> These specialized chromosome caps also help protect the DNA ends, and stop the <a href="http://en.wikipedia.org/wiki/DNA_repair" title="DNA repair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA repair</a> systems in the cell from treating them as damage to be corrected.<sup id="cite_ref-Nugent_56-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nugent-56" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[56]</a></sup> In <a href="http://en.wikipedia.org/wiki/List_of_distinct_cell_types_in_the_adult_human_body" title="List of distinct cell types in the adult human body" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">human cells</a>, telomeres are usually lengths of single-stranded DNA containing several thousand repeats of a simple TTAGGG sequence.<sup id="cite_ref-57" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-57" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[57]</a></sup></p>
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DNA quadruplex formed by <a href="http://en.wikipedia.org/wiki/Telomere" title="Telomere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomere</a>repeats. The looped conformation of the DNA backbone is very different from the typical DNA helix.<sup id="cite_ref-58" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-58" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[58]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">These guanine-rich sequences may stabilize chromosome ends by forming structures of stacked sets of four-base units, rather than the usual base pairs found in other DNA molecules. Here, four guanine bases form a flat plate and these flat four-base units then stack on top of each other, to form a stable <a href="http://en.wikipedia.org/wiki/G-quadruplex" title="G-quadruplex" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">G-quadruplex</a> structure.<sup id="cite_ref-Burge_59-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Burge-59" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[59]</a></sup> These structures are stabilized by hydrogen bonding between the edges of the bases and <a href="http://en.wikipedia.org/wiki/Chelation" title="Chelation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chelation</a> of a metal ion in the centre of each four-base unit.<sup id="cite_ref-60" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-60" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[60]</a></sup> Other structures can also be formed, with the central set of four bases coming from either a single strand folded around the bases, or several different parallel strands, each contributing one base to the central structure.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In addition to these stacked structures, telomeres also form large loop structures called telomere loops, or T-loops. Here, the single-stranded DNA curls around in a long circle stabilized by telomere-binding proteins.<sup id="cite_ref-61" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-61" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[61]</a></sup> At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere strand disrupting the double-helical DNA and base pairing to one of the two strands. This <a href="http://en.wikipedia.org/wiki/Triple-stranded_DNA" title="Triple-stranded DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">triple-stranded</a> structure is called a displacement loop or <a href="http://en.wikipedia.org/wiki/D-loop" title="D-loop" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">D-loop</a>.<sup id="cite_ref-Burge_59-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Burge-59" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[59]</a></sup></p>
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<td><a href="http://en.wikipedia.org/wiki/File:Branch-dna-single.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Branch-dna-single.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/5/54/Branch-dna-single.svg/95px-Branch-dna-single.svg.png" width="95" height="71" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Branch-dna-single.svg/143px-Branch-dna-single.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/54/Branch-dna-single.svg/190px-Branch-dna-single.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td><a href="http://en.wikipedia.org/wiki/File:Branch-DNA-multiple.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Branch-DNA-multiple.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/0/08/Branch-DNA-multiple.svg/95px-Branch-DNA-multiple.svg.png" width="95" height="71" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Branch-DNA-multiple.svg/143px-Branch-DNA-multiple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Branch-DNA-multiple.svg/190px-Branch-DNA-multiple.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<td align="center">Single branch</td>
<td align="center">Multiple branches</td>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; padding: 3px !important;"><a href="http://en.wikipedia.org/wiki/Branched_DNA" title="Branched DNA" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Branched DNA</a> can form networks containing multiple branches.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Branched_DNA">Branched DNA</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Branched_DNA" title="Branched DNA" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Branched DNA</a> and <a href="http://en.wikipedia.org/wiki/DNA_nanotechnology" title="DNA nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA nanotechnology</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In DNA <a href="http://en.wikipedia.org/wiki/DNA_end#Frayed_ends" title="DNA end" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">fraying</a> occurs when non-complementary regions exist at the end of an otherwise complementary double-strand of DNA. However, branched DNA can occur if a third strand of DNA is introduced and contains adjoining regions able to hybridize with the frayed regions of the pre-existing double-strand. Although the simplest example of branched DNA involves only three strands of DNA, complexes involving additional strands and multiple branches are also possible.<sup id="cite_ref-62" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-62" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[62]</a></sup> Branched DNA can be used in <a href="http://en.wikipedia.org/wiki/Nanotechnology" title="Nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nanotechnology</a> to construct geometric shapes, see the section on <a href="http://en.wikipedia.org/wiki/DNA#Uses_in_technology" title="DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">uses in technology</a> below.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Vibration">Vibration</span></h3>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA may carry out <a href="http://en.wikipedia.org/wiki/Low-frequency_collective_motion_in_proteins_and_DNA" title="Low-frequency collective motion in proteins and DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">low-frequency</a> collective motion as observed by the <a href="http://en.wikipedia.org/wiki/Raman_spectroscopy" title="Raman spectroscopy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Raman spectroscopy</a><sup id="cite_ref-pmid7115900_63-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-pmid7115900-63" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[63]</a></sup><sup id="cite_ref-Urabe_1983_64-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Urabe_1983-64" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[64]</a></sup> and analyzed with a quasi-continuum model.<sup id="cite_ref-pmid6466317_65-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-pmid6466317-65" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[65]</a></sup><sup id="cite_ref-pmid2775828_66-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-pmid2775828-66" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[66]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Chemical_modifications_and_altered_DNA_packaging">Chemical modifications and altered DNA packaging</span></h2>
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<td><a href="http://en.wikipedia.org/wiki/File:Cytosin.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Cytosin.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Cytosin.svg/75px-Cytosin.svg.png" width="75" height="102" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Cytosin.svg/113px-Cytosin.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Cytosin.svg/150px-Cytosin.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td><a href="http://en.wikipedia.org/wiki/File:5-Methylcytosine.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="5-Methylcytosine.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/3/3a/5-Methylcytosine.svg/95px-5-Methylcytosine.svg.png" width="95" height="83" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3a/5-Methylcytosine.svg/143px-5-Methylcytosine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3a/5-Methylcytosine.svg/190px-5-Methylcytosine.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
<td><a href="http://en.wikipedia.org/wiki/File:Thymin.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="Thymin.svg" src="http://upload.wikimedia.org/wikipedia/commons/thumb/1/15/Thymin.svg/97px-Thymin.svg.png" width="97" height="83" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Thymin.svg/146px-Thymin.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/15/Thymin.svg/194px-Thymin.svg.png 2x" style="border: none; vertical-align: middle;" /></a></td>
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<td align="center"><a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a></td>
<td align="center"><a href="http://en.wikipedia.org/wiki/5-Methylcytosine" title="5-Methylcytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5-methylcytosine</a></td>
<td align="center"><a href="http://en.wikipedia.org/wiki/Thymine" title="Thymine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine</a></td>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; padding: 3px !important;">Structure of cytosine with and without the 5-methyl group. <a href="http://en.wikipedia.org/wiki/Deamination" title="Deamination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Deamination</a> converts 5-methylcytosine into thymine.</div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Base_modifications_and_DNA_packaging">Base modifications and DNA packaging</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_methylation" title="DNA methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA methylation</a>, <a href="http://en.wikipedia.org/wiki/Chromatin_remodeling" title="Chromatin remodeling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromatin remodeling</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The expression of genes is influenced by how the DNA is packaged in chromosomes, in a structure called <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromatin</a>. Base modifications can be involved in packaging, with regions that have low or no gene expression usually containing high levels of<a href="http://en.wikipedia.org/wiki/Methylation" title="Methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methylation</a> of <a href="http://en.wikipedia.org/wiki/Cytosine" title="Cytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cytosine</a> bases. DNA packaging and its influence on gene expression can also occur by covalent modifications of the <a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histone</a> protein core around which DNA is wrapped in the chromatin structure or else by remodeling carried out by chromatin remodeling complexes (see <a href="http://en.wikipedia.org/wiki/Chromatin_remodeling" title="Chromatin remodeling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromatin remodeling</a>). There is, further, <a href="http://en.wikipedia.org/wiki/Crosstalk_(biology)" title="Crosstalk (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">crosstalk</a> between DNA methylation and histone modification, so they can coordinately affect chromatin and gene expression.<sup id="cite_ref-67" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-67" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[67]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">For one example, cytosine methylation, produces <a href="http://en.wikipedia.org/wiki/5-Methylcytosine" title="5-Methylcytosine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5-methylcytosine</a>, which is important for <a href="http://en.wikipedia.org/wiki/X-inactivation" title="X-inactivation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-chromosome inactivation</a>.<sup id="cite_ref-68" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-68" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[68]</a></sup> The average level of methylation varies between organisms – the worm <i><a href="http://en.wikipedia.org/wiki/Caenorhabditis_elegans" title="Caenorhabditis elegans" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Caenorhabditis elegans</a></i> lacks cytosine methylation, while <a href="http://en.wikipedia.org/wiki/Vertebrate" title="Vertebrate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">vertebrates</a> have higher levels, with up to 1% of their DNA containing 5-methylcytosine.<sup id="cite_ref-69" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-69" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[69]</a></sup> Despite the importance of 5-methylcytosine, it can <a href="http://en.wikipedia.org/wiki/Deamination" title="Deamination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">deaminate</a> to leave a thymine base, so methylated cytosines are particularly prone to<a href="http://en.wikipedia.org/wiki/Mutation" title="Mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutations</a>.<sup id="cite_ref-70" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-70" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[70]</a></sup> Other base modifications include adenine methylation in bacteria, the presence of <a href="http://en.wikipedia.org/wiki/5-hydroxymethylcytosine" title="5-hydroxymethylcytosine" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">5-hydroxymethylcytosine</a> in the <a href="http://en.wikipedia.org/wiki/Brain" title="Brain" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">brain</a>,<sup id="cite_ref-71" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-71" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[71]</a></sup> and the <a href="http://en.wikipedia.org/wiki/Glycosylation" title="Glycosylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">glycosylation</a> of uracil to produce the "J-base" in <a href="http://en.wikipedia.org/wiki/Kinetoplastid" title="Kinetoplastid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">kinetoplastids</a>.<sup id="cite_ref-72" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-72" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[72]</a></sup><sup id="cite_ref-73" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-73" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[73]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Damage">Damage</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_damage_(naturally_occurring)" title="DNA damage (naturally occurring)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA damage (naturally occurring)</a>, <a href="http://en.wikipedia.org/wiki/Mutation" title="Mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Mutation</a>, <a href="http://en.wikipedia.org/wiki/DNA_damage_theory_of_aging" title="DNA damage theory of aging" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA damage theory of aging</a></div>
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A <a href="http://en.wikipedia.org/wiki/Covalent" title="Covalent" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">covalent</a> <a href="http://en.wikipedia.org/wiki/Adduct" title="Adduct" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adduct</a> between a<a href="http://en.wikipedia.org/wiki/Cytochrome_P450,_family_1,_member_A1" title="Cytochrome P450, family 1, member A1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">metabolically activated</a> form of<a href="http://en.wikipedia.org/wiki/Benzo(a)pyrene" title="Benzo(a)pyrene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">benzo[<i>a</i>]pyrene</a>, the major <a href="http://en.wikipedia.org/wiki/Mutagen" title="Mutagen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutagen</a> in<a href="http://en.wikipedia.org/wiki/Tobacco_smoking" title="Tobacco smoking" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">tobacco smoke</a>, and DNA<sup id="cite_ref-74" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-74" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[74]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA can be damaged by many sorts of <a href="http://en.wikipedia.org/wiki/Mutagen" title="Mutagen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutagens</a>, which change the DNA sequence. Mutagens include <a href="http://en.wikipedia.org/wiki/Oxidizing_agent" title="Oxidizing agent" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">oxidizing agents</a>, <a href="http://en.wikipedia.org/wiki/Alkylation" title="Alkylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">alkylating agents</a>and also high-energy <a href="http://en.wikipedia.org/wiki/Electromagnetic_radiation" title="Electromagnetic radiation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">electromagnetic radiation</a> such as <a href="http://en.wikipedia.org/wiki/Ultraviolet" title="Ultraviolet" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ultraviolet</a> light and <a href="http://en.wikipedia.org/wiki/X-ray" title="X-ray" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-rays</a>. The type of DNA damage produced depends on the type of mutagen. For example, UV light can damage DNA by producing <a href="http://en.wikipedia.org/wiki/Thymine_dimer" title="Thymine dimer" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">thymine dimers</a>, which are cross-links between pyrimidine bases.<sup id="cite_ref-75" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-75" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[75]</a></sup> On the other hand, oxidants such as <a href="http://en.wikipedia.org/wiki/Radical_(chemistry)" title="Radical (chemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">free radicals</a> or <a href="http://en.wikipedia.org/wiki/Hydrogen_peroxide" title="Hydrogen peroxide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrogen peroxide</a> produce multiple forms of damage, including base modifications, particularly of guanosine, and double-strand breaks.<sup id="cite_ref-76" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-76" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[76]</a></sup> A typical human cell contains about 150,000 bases that have suffered oxidative damage.<sup id="cite_ref-77" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-77" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[77]</a></sup> Of these oxidative lesions, the most dangerous are double-strand breaks, as these are difficult to repair and can produce <a href="http://en.wikipedia.org/wiki/Point_mutation" title="Point mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">point mutations</a>, <a href="http://en.wikipedia.org/wiki/Genetic_insertion" title="Genetic insertion" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">insertions</a> and <a href="http://en.wikipedia.org/wiki/Deletion_(genetics)" title="Deletion (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">deletions</a> from the DNA sequence, as well as <a href="http://en.wikipedia.org/wiki/Chromosomal_translocation" title="Chromosomal translocation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomal translocations</a>.<sup id="cite_ref-78" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-78" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[78]</a></sup> These mutations can cause<a href="http://en.wikipedia.org/wiki/Cancer" title="Cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cancer</a>. Because of inherent limitations in the DNA repair mechanisms, if humans lived long enough, they would all eventually develop cancer.<sup id="cite_ref-Weinberg_79-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Weinberg-79" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[79]</a></sup><sup id="cite_ref-80" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-80" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[80]</a></sup> DNA damages that are <a href="http://en.wikipedia.org/wiki/DNA_damage_(naturally_occurring)" title="DNA damage (naturally occurring)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">naturally occurring</a>, due to normal cellular processes that produce reactive oxygen species, the hydrolytic activities of cellular water, etc., also occur frequently. Although most of these damages are repaired, in any cell some DNA damage may remain despite the action of repair processes. These remaining DNA damages accumulate with age in mammalian postmitotic tissues. This accumulation appears to be an important underlying cause of aging.<sup id="cite_ref-81" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-81" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[81]</a></sup><sup id="cite_ref-82" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-82" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[82]</a></sup><sup id="cite_ref-83" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-83" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[83]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Many mutagens fit into the space between two adjacent base pairs, this is called <i><a href="http://en.wikipedia.org/wiki/Intercalation_(chemistry)" title="Intercalation (chemistry)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">intercalation</a></i>. Most intercalators are <a href="http://en.wikipedia.org/wiki/Aromaticity" title="Aromaticity" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aromatic</a> and planar molecules; examples include <a href="http://en.wikipedia.org/wiki/Ethidium_bromide" title="Ethidium bromide" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ethidium bromide</a>, <a href="http://en.wikipedia.org/wiki/Acridine" title="Acridine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">acridines</a>, <a href="http://en.wikipedia.org/wiki/Daunorubicin" title="Daunorubicin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">daunomycin</a>, and <a href="http://en.wikipedia.org/wiki/Doxorubicin" title="Doxorubicin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doxorubicin</a>. For an intercalator to fit between base pairs, the bases must separate, distorting the DNA strands by unwinding of the double helix. This inhibits both transcription and DNA replication, causing toxicity and mutations.<sup id="cite_ref-84" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-84" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[84]</a></sup> As a result, DNA intercalators may be <a href="http://en.wikipedia.org/wiki/Carcinogen" title="Carcinogen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">carcinogens</a>, and in the case of thalidomide, a <a href="http://en.wikipedia.org/wiki/Teratogen" title="Teratogen" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">teratogen</a>.<sup id="cite_ref-85" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-85" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[85]</a></sup>Others such as <a href="http://en.wikipedia.org/wiki/Benzo(a)pyrene" title="Benzo(a)pyrene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">benzo[<i>a</i>]pyrene diol epoxide</a> and <a href="http://en.wikipedia.org/wiki/Aflatoxin" title="Aflatoxin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aflatoxin</a> form DNA adducts that induce errors in replication.<sup id="cite_ref-86" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-86" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[86]</a></sup> Nevertheless, due to their ability to inhibit DNA transcription and replication, other similar toxins are also used in <a href="http://en.wikipedia.org/wiki/Chemotherapy" title="Chemotherapy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chemotherapy</a> to inhibit rapidly growing <a href="http://en.wikipedia.org/wiki/Cancer" title="Cancer" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cancer</a> cells.<sup id="cite_ref-87" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-87" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[87]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Biological_functions">Biological functions</span></h2>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA usually occurs as linear <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomes</a> in <a href="http://en.wikipedia.org/wiki/Eukaryote" title="Eukaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">eukaryotes</a>, and circular chromosomes in <a href="http://en.wikipedia.org/wiki/Prokaryote" title="Prokaryote" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">prokaryotes</a>. The set of chromosomes in a cell makes up its <a href="http://en.wikipedia.org/wiki/Genome" title="Genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genome</a>; the <a href="http://en.wikipedia.org/wiki/Human_genome" title="Human genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">human genome</a> has approximately 3 billion base pairs of DNA arranged into 46 chromosomes.<sup id="cite_ref-88" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-88" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[88]</a></sup> The information carried by DNA is held in the <a href="http://en.wikipedia.org/wiki/DNA_sequence" title="DNA sequence" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">sequence</a> of pieces of DNA called <a href="http://en.wikipedia.org/wiki/Gene" title="Gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genes</a>. <a href="http://en.wikipedia.org/wiki/Transmission_(genetics)" title="Transmission (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Transmission</a> of genetic information in genes is achieved via complementary base pairing. For example, in transcription, when a cell uses the information in a gene, the DNA sequence is copied into a complementary RNA sequence through the attraction between the DNA and the correct RNA nucleotides. Usually, this RNA copy is then used to make a matching <a href="http://en.wikipedia.org/wiki/Peptide_sequence" title="Peptide sequence" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein sequence</a> in a process called <a href="http://en.wikipedia.org/wiki/Translation_(biology)" title="Translation (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">translation</a>, which depends on the same interaction between RNA nucleotides. In alternative fashion, a cell may simply copy its genetic information in a process called DNA replication. The details of these functions are covered in other articles; here we focus on the interactions between DNA and other molecules that mediate the function of the genome.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Genes_and_genomes">Genes and genomes</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Cell_nucleus" title="Cell nucleus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Cell nucleus</a>, <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromatin</a>, <a href="http://en.wikipedia.org/wiki/Chromosome" title="Chromosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chromosome</a>, <a href="http://en.wikipedia.org/wiki/Gene" title="Gene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Gene</a>, <a href="http://en.wikipedia.org/wiki/Noncoding_DNA" title="Noncoding DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Noncoding DNA</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Genomic DNA is tightly and orderly packed in the process called <a href="http://en.wikipedia.org/wiki/DNA_condensation" title="DNA condensation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA condensation</a> to fit the small available volumes of the cell. In eukaryotes, DNA is located in the <a href="http://en.wikipedia.org/wiki/Cell_nucleus" title="Cell nucleus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell nucleus</a>, as well as small amounts in <a href="http://en.wikipedia.org/wiki/Mitochondrion" title="Mitochondrion" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mitochondria</a> and <a href="http://en.wikipedia.org/wiki/Chloroplast" title="Chloroplast" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chloroplasts</a>. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the <a href="http://en.wikipedia.org/wiki/Nucleoid" title="Nucleoid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoid</a>.<sup id="cite_ref-89" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-89" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[89]</a></sup> The genetic information in a genome is held within genes, and the complete set of this information in an organism is called its <a href="http://en.wikipedia.org/wiki/Genotype" title="Genotype" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genotype</a>. A gene is a unit of <a href="http://en.wikipedia.org/wiki/Heredity" title="Heredity" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">heredity</a> and is a region of DNA that influences a particular characteristic in an organism. Genes contain an <a href="http://en.wikipedia.org/wiki/Open_reading_frame" title="Open reading frame" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">open reading frame</a> that can be transcribed, as well as <a href="http://en.wikipedia.org/wiki/Regulatory_sequence" title="Regulatory sequence" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">regulatory sequences</a> such as <a href="http://en.wikipedia.org/wiki/Promoter_(biology)" title="Promoter (biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">promoters</a> and <a href="http://en.wikipedia.org/wiki/Enhancer_(genetics)" title="Enhancer (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enhancers</a>, which control the transcription of the open reading frame.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In many <a href="http://en.wikipedia.org/wiki/Species" title="Species" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">species</a>, only a small fraction of the total sequence of the <a href="http://en.wikipedia.org/wiki/Genome" title="Genome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genome</a> encodes protein. For example, only about 1.5% of the human genome consists of protein-coding <a href="http://en.wikipedia.org/wiki/Exon" title="Exon" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">exons</a>, with over 50% of human DNA consisting of non-coding <a href="http://en.wikipedia.org/wiki/Repeated_sequence_(DNA)" title="Repeated sequence (DNA)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">repetitive sequences</a>.<sup id="cite_ref-90" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-90" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[90]</a></sup> The reasons for the presence of so much <a href="http://en.wikipedia.org/wiki/Noncoding_DNA" title="Noncoding DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">noncoding DNA</a> in eukaryotic genomes and the extraordinary differences in <a href="http://en.wikipedia.org/wiki/Genome_size" title="Genome size" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genome size</a>, or <i><a href="http://en.wikipedia.org/wiki/C-value" title="C-value" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">C-value</a></i>, among species represent a long-standing puzzle known as the "<a href="http://en.wikipedia.org/wiki/C-value_enigma" title="C-value enigma" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">C-value enigma</a>".<sup id="cite_ref-91" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-91" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[91]</a></sup> However, some DNA sequences that do not code protein may still encode functional <a href="http://en.wikipedia.org/wiki/Non-coding_RNA" title="Non-coding RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">non-coding RNA</a> molecules, which are involved in the <a href="http://en.wikipedia.org/wiki/Regulation_of_gene_expression" title="Regulation of gene expression" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">regulation of gene expression</a>.<sup id="cite_ref-92" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-92" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[92]</a></sup></p>
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<a href="http://en.wikipedia.org/wiki/T7_RNA_polymerase" title="T7 RNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">T7 RNA polymerase</a> (blue) producing a mRNA (green) from a DNA template (orange).<sup id="cite_ref-93" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-93" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[93]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Some noncoding DNA sequences play structural roles in chromosomes. <a href="http://en.wikipedia.org/wiki/Telomere" title="Telomere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Telomeres</a> and <a href="http://en.wikipedia.org/wiki/Centromere" title="Centromere" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">centromeres</a> typically contain few genes, but are important for the function and stability of chromosomes.<sup id="cite_ref-Nugent_56-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nugent-56" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[56]</a></sup><sup id="cite_ref-94" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-94" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[94]</a></sup> An abundant form of noncoding DNA in humans are <a href="http://en.wikipedia.org/wiki/Pseudogene" title="Pseudogene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">pseudogenes</a>, which are copies of genes that have been disabled by mutation.<sup id="cite_ref-95" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-95" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[95]</a></sup> These sequences are usually just molecular <a href="http://en.wikipedia.org/wiki/Fossil" title="Fossil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">fossils</a>, although they can occasionally serve as raw genetic material for the creation of new genes through the process of <a href="http://en.wikipedia.org/wiki/Gene_duplication" title="Gene duplication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene duplication</a> and <a href="http://en.wikipedia.org/wiki/Divergent_evolution" title="Divergent evolution" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">divergence</a>.<sup id="cite_ref-96" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-96" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[96]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Transcription_and_translation">Transcription and translation</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Genetic_code" title="Genetic code" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic code</a>, <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" title="Transcription (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Transcription (genetics)</a>, <a href="http://en.wikipedia.org/wiki/Protein_biosynthesis" title="Protein biosynthesis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Protein biosynthesis</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A gene is a sequence of DNA that contains genetic information and can influence the <a href="http://en.wikipedia.org/wiki/Phenotype" title="Phenotype" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phenotype</a> of an organism. Within a gene, the sequence of bases along a DNA strand defines a <a href="http://en.wikipedia.org/wiki/Messenger_RNA" title="Messenger RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">messenger RNA</a> sequence, which then defines one or more protein sequences. The relationship between the nucleotide sequences of genes and the <a href="http://en.wikipedia.org/wiki/Amino_acid" title="Amino acid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">amino-acid</a> sequences of proteins is determined by the rules of <a href="http://en.wikipedia.org/wiki/Translation_(biology)" title="Translation (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">translation</a>, known collectively as the <a href="http://en.wikipedia.org/wiki/Genetic_code" title="Genetic code" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic code</a>. The genetic code consists of three-letter 'words' called <i>codons</i> formed from a sequence of three nucleotides (e.g. ACT, CAG, TTT).</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In transcription, the codons of a gene are copied into messenger RNA by <a href="http://en.wikipedia.org/wiki/RNA_polymerase" title="RNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase</a>. This RNA copy is then decoded by a <a href="http://en.wikipedia.org/wiki/Ribosome" title="Ribosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ribosome</a>that reads the RNA sequence by base-pairing the messenger RNA to <a href="http://en.wikipedia.org/wiki/Transfer_RNA" title="Transfer RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transfer RNA</a>, which carries amino acids. Since there are 4 bases in 3-letter combinations, there are 64 possible codons (<img class="tex" alt="4^3" src="http://upload.wikimedia.org/math/2/9/b/29b8a6aa9d0f15d19fae3aa4c6d6c883.png" style="border: none; vertical-align: middle; margin: 0px;" /> combinations). These encode the twenty <a href="http://en.wikipedia.org/wiki/List_of_standard_amino_acids" title="List of standard amino acids" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">standard amino acids</a>, giving most amino acids more than one possible codon. There are also three 'stop' or 'nonsense' codons signifying the end of the coding region; these are the TAA, TGA and TAG codons.</p>
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DNA replication. The double helix is unwound by a <a href="http://en.wikipedia.org/wiki/Helicase" title="Helicase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">helicase</a> and <a href="http://en.wikipedia.org/wiki/Topoisomerase" title="Topoisomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">topoisomerase</a>. Next, one <a href="http://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA polymerase</a> produces the <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">leading strand</a> copy. Another DNA polymerase binds to the <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">lagging strand</a>. This enzyme makes discontinuous segments (called <a href="http://en.wikipedia.org/wiki/Okazaki_fragment" title="Okazaki fragment" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Okazaki fragments</a>) before <a href="http://en.wikipedia.org/wiki/DNA_ligase" title="DNA ligase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA ligase</a> joins them together.</div>
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<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Cell_division" title="Cell division" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Cell division</a> is essential for an organism to grow, but, when a cell divides, it must replicate the DNA in its genome so that the two daughter cells have the same genetic information as their parent. The double-stranded structure of DNA provides a simple mechanism for <a href="http://en.wikipedia.org/wiki/DNA_replication" title="DNA replication" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA replication</a>. Here, the two strands are separated and then each strand's <a href="http://en.wikipedia.org/wiki/Complementary_DNA" title="Complementary DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">complementary DNA</a> sequence is recreated by an<a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzyme</a> called <a href="http://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA polymerase</a>. This enzyme makes the complementary strand by finding the correct base through complementary base pairing, and bonding it onto the original strand. As DNA polymerases can only extend a DNA strand in a 5′ to 3′ direction, different mechanisms are used to copy the antiparallel strands of the double helix.<sup id="cite_ref-97" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-97" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[97]</a></sup> In this way, the base on the old strand dictates which base appears on the new strand, and the cell ends up with a perfect copy of its DNA.</p>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">All the functions of DNA depend on interactions with proteins. These <a href="http://en.wikipedia.org/wiki/Protein_interactions" title="Protein interactions" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein interactions</a> can be non-specific, or the protein can bind specifically to a single DNA sequence. Enzymes can also bind to DNA and of these, the polymerases that copy the DNA base sequence in transcription and DNA replication are particularly important.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="DNA-binding_proteins">DNA-binding proteins</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA-binding_protein" title="DNA-binding protein" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA-binding protein</a></div>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; font-size: 12px; padding: 3px !important;">Interaction of DNA (shown in orange) with<a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histones</a> (shown in blue). These proteins' basic amino acids bind to the acidic phosphate groups on DNA.</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held in complexes with structural proteins. These proteins organize the DNA into a compact structure called <a href="http://en.wikipedia.org/wiki/Chromatin" title="Chromatin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromatin</a>. In eukaryotes this structure involves DNA binding to a complex of small basic proteins called <a href="http://en.wikipedia.org/wiki/Histone" title="Histone" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">histones</a>, while in prokaryotes multiple types of proteins are involved.<sup id="cite_ref-98" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-98" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[98]</a></sup><sup id="cite_ref-99" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-99" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[99]</a></sup> The histones form a disk-shaped complex called a <a href="http://en.wikipedia.org/wiki/Nucleosome" title="Nucleosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleosome</a>, which contains two complete turns of double-stranded DNA wrapped around its surface. These non-specific interactions are formed through basic residues in the histones making<a href="http://en.wikipedia.org/wiki/Ionic_bond" title="Ionic bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ionic bonds</a> to the acidic sugar-phosphate backbone of the DNA, and are therefore largely independent of the base sequence.<sup id="cite_ref-100" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-100" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[100]</a></sup>Chemical modifications of these basic amino acid residues include <a href="http://en.wikipedia.org/wiki/Methylation" title="Methylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">methylation</a>, <a href="http://en.wikipedia.org/wiki/Phosphorylation" title="Phosphorylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphorylation</a> and <a href="http://en.wikipedia.org/wiki/Acetylation" title="Acetylation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">acetylation</a>.<sup id="cite_ref-101" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-101" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[101]</a></sup> These chemical changes alter the strength of the interaction between the DNA and the histones, making the DNA more or less accessible to<a href="http://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription factors</a> and changing the rate of transcription.<sup id="cite_ref-102" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-102" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[102]</a></sup> Other non-specific DNA-binding proteins in chromatin include the high-mobility group proteins, which bind to bent or distorted DNA.<sup id="cite_ref-103" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-103" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[103]</a></sup> These proteins are important in bending arrays of nucleosomes and arranging them into the larger structures that make up chromosomes.<sup id="cite_ref-104" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-104" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[104]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. In humans, replication<a href="http://en.wikipedia.org/wiki/Protein_A" title="Protein A" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein A</a> is the best-understood member of this family and is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair.<sup id="cite_ref-105" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-105" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[105]</a></sup> These binding proteins seem to stabilize single-stranded DNA and protect it from forming <a href="http://en.wikipedia.org/wiki/Stem-loop" title="Stem-loop" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">stem-loops</a> or being degraded by <a href="http://en.wikipedia.org/wiki/Nuclease" title="Nuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleases</a>.</p>
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The lambda repressor <a href="http://en.wikipedia.org/wiki/Helix-turn-helix" title="Helix-turn-helix" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">helix-turn-helix</a> transcription factor bound to its DNA target<sup id="cite_ref-106" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-106" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[106]</a></sup></div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In contrast, other proteins have evolved to bind to particular DNA sequences. The most intensively studied of these are the various <a href="http://en.wikipedia.org/wiki/Transcription_factor" title="Transcription factor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transcription factors</a>, which are proteins that regulate transcription. Each transcription factor binds to one particular set of DNA sequences and activates or inhibits the transcription of genes that have these sequences close to their promoters. The transcription factors do this in two ways. Firstly, they can bind the RNA polymerase responsible for transcription, either directly or through other mediator proteins; this locates the polymerase at the promoter and allows it to begin transcription.<sup id="cite_ref-107" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-107" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[107]</a></sup> Alternatively, transcription factors can bind <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> that modify the histones at the promoter. This changes the accessibility of the DNA template to the polymerase.<sup id="cite_ref-108" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-108" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[108]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">As these DNA targets can occur throughout an organism's genome, changes in the activity of one type of transcription factor can affect thousands of genes.<sup id="cite_ref-109" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-109" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[109]</a></sup> Consequently, these proteins are often the targets of the <a href="http://en.wikipedia.org/wiki/Signal_transduction" title="Signal transduction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">signal transduction</a> processes that control responses to environmental changes or <a href="http://en.wikipedia.org/wiki/Cellular_differentiation" title="Cellular differentiation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cellular differentiation</a> and development. The specificity of these transcription factors' interactions with DNA come from the proteins making multiple contacts to the edges of the DNA bases, allowing them to "read" the DNA sequence. Most of these base-interactions are made in the major groove, where the bases are most accessible.<sup id="cite_ref-Pabo1984_25-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Pabo1984-25" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[25]</a></sup></p>
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The <a href="http://en.wikipedia.org/wiki/Restriction_enzyme" title="Restriction enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction enzyme</a> <a href="http://en.wikipedia.org/wiki/EcoRV" title="EcoRV" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">EcoRV</a>(green) in a complex with its substrate DNA<sup id="cite_ref-110" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-110" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[110]</a></sup></div>
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<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="DNA-modifying_enzymes">DNA-modifying enzymes</span></h3>
<h4 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 15.199999809265137px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Nucleases_and_ligases">Nucleases and ligases</span></h4>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Nuclease" title="Nuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nucleases</a> are <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> that cut DNA strands by catalyzing the <a href="http://en.wikipedia.org/wiki/Hydrolysis" title="Hydrolysis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydrolysis</a> of the <a href="http://en.wikipedia.org/wiki/Phosphodiester_bond" title="Phosphodiester bond" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phosphodiester bonds</a>. Nucleases that hydrolyse nucleotides from the ends of DNA strands are called <a href="http://en.wikipedia.org/wiki/Exonuclease" title="Exonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">exonucleases</a>, while<a href="http://en.wikipedia.org/wiki/Endonuclease" title="Endonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">endonucleases</a> cut within strands. The most frequently used nucleases in <a href="http://en.wikipedia.org/wiki/Molecular_biology" title="Molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular biology</a> are the<a href="http://en.wikipedia.org/wiki/Restriction_enzyme" title="Restriction enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction endonucleases</a>, which cut DNA at specific sequences. For instance, the EcoRV enzyme shown to the left recognizes the 6-base sequence 5′-GATATC-3′ and makes a cut at the vertical line. In nature, these enzymes protect <a href="http://en.wikipedia.org/wiki/Bacteria" title="Bacteria" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">bacteria</a> against <a href="http://en.wikipedia.org/wiki/Bacteriophage" title="Bacteriophage" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phage</a> infection by digesting the phage DNA when it enters the bacterial cell, acting as part of the <a href="http://en.wikipedia.org/wiki/Restriction_modification_system" title="Restriction modification system" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction modification system</a>.<sup id="cite_ref-111" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-111" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[111]</a></sup> In technology, these sequence-specific nucleases are used in <a href="http://en.wikipedia.org/wiki/Molecular_cloning" title="Molecular cloning" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular cloning</a> and <a href="http://en.wikipedia.org/wiki/Genetic_fingerprinting" title="Genetic fingerprinting" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA fingerprinting</a>.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Enzymes called <a href="http://en.wikipedia.org/wiki/DNA_ligase" title="DNA ligase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA ligases</a> can rejoin cut or broken DNA strands.<sup id="cite_ref-Doherty_112-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Doherty-112" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[112]</a></sup> Ligases are particularly important in <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">lagging strand</a> DNA replication, as they join together the short segments of DNA produced at the <a href="http://en.wikipedia.org/wiki/Replication_fork" title="Replication fork" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">replication fork</a> into a complete copy of the DNA template. They are also used in <a href="http://en.wikipedia.org/wiki/DNA_repair" title="DNA repair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA repair</a> and <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic recombination</a>.<sup id="cite_ref-Doherty_112-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Doherty-112" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[112]</a></sup></p>
<h4 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 15.199999809265137px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Topoisomerases_and_helicases">Topoisomerases and helicases</span></h4>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Topoisomerase" title="Topoisomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Topoisomerases</a> are enzymes with both nuclease and ligase activity. These proteins change the amount of <a href="http://en.wikipedia.org/wiki/DNA_supercoil" title="DNA supercoil" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">supercoiling</a> in DNA. Some of these enzymes work by cutting the DNA helix and allowing one section to rotate, thereby reducing its level of supercoiling; the enzyme then seals the DNA break.<sup id="cite_ref-Champoux_37-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Champoux-37" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[37]</a></sup> Other types of these enzymes are capable of cutting one DNA helix and then passing a second strand of DNA through this break, before rejoining the helix.<sup id="cite_ref-113" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-113" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[113]</a></sup> Topoisomerases are required for many processes involving DNA, such as DNA replication and transcription.<sup id="cite_ref-Wang_38-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Wang-38" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[38]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Helicase" title="Helicase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Helicases</a> are proteins that are a type of <a href="http://en.wikipedia.org/wiki/Molecular_motor" title="Molecular motor" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular motor</a>. They use the chemical energy in <a href="http://en.wikipedia.org/wiki/Nucleoside_triphosphate" title="Nucleoside triphosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoside triphosphates</a>, predominantly <a href="http://en.wikipedia.org/wiki/Adenosine_triphosphate" title="Adenosine triphosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ATP</a>, to break hydrogen bonds between bases and unwind the DNA double helix into single strands.<sup id="cite_ref-114" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-114" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[114]</a></sup> These enzymes are essential for most processes where enzymes need to access the DNA bases.</p>
<h4 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 15.199999809265137px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Polymerases">Polymerases</span></h4>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Polymerase" title="Polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Polymerases</a> are <a href="http://en.wikipedia.org/wiki/Enzyme" title="Enzyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">enzymes</a> that synthesize polynucleotide chains from <a href="http://en.wikipedia.org/wiki/Nucleoside_triphosphate" title="Nucleoside triphosphate" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleoside triphosphates</a>. The sequence of their products are copies of existing polynucleotide chains—which are called <i>templates</i>. These enzymes function by adding nucleotides onto the 3′ <a href="http://en.wikipedia.org/wiki/Hydroxyl" title="Hydroxyl" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hydroxyl group</a> of the previous nucleotide in a DNA strand. As a consequence, all polymerases work in a 5′ to 3′ direction.<sup id="cite_ref-Joyce_115-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Joyce-115" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[115]</a></sup> In the <a href="http://en.wikipedia.org/wiki/Active_site" title="Active site" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">active site</a> of these enzymes, the incoming nucleoside triphosphate base-pairs to the template: this allows polymerases to accurately synthesize the complementary strand of their template. Polymerases are classified according to the type of template that they use.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In DNA replication, a DNA-dependent <a href="http://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA polymerase</a> makes a copy of a DNA sequence. Accuracy is vital in this process, so many of these polymerases have a <a href="http://en.wikipedia.org/wiki/Proofreading_(Biology)" title="Proofreading (Biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">proofreading</a> activity. Here, the polymerase recognizes the occasional mistakes in the synthesis reaction by the lack of base pairing between the mismatched nucleotides. If a mismatch is detected, a 3′ to 5′ <a href="http://en.wikipedia.org/wiki/Exonuclease" title="Exonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">exonuclease</a> activity is activated and the incorrect base removed.<sup id="cite_ref-116" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-116" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[116]</a></sup> In most organisms, DNA polymerases function in a large complex called the <a href="http://en.wikipedia.org/wiki/Replisome" title="Replisome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">replisome</a> that contains multiple accessory subunits, such as the <a href="http://en.wikipedia.org/wiki/DNA_clamp" title="DNA clamp" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA clamp</a> or <a href="http://en.wikipedia.org/wiki/Helicase" title="Helicase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">helicases</a>.<sup id="cite_ref-117" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-117" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[117]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">RNA-dependent DNA polymerases are a specialized class of polymerases that copy the sequence of an RNA strand into DNA. They include <a href="http://en.wikipedia.org/wiki/Reverse_transcriptase" title="Reverse transcriptase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">reverse transcriptase</a>, which is a <a href="http://en.wikipedia.org/wiki/Virus" title="Virus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viral</a>enzyme involved in the infection of cells by <a href="http://en.wikipedia.org/wiki/Retrovirus" title="Retrovirus" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">retroviruses</a>, and <a href="http://en.wikipedia.org/wiki/Telomerase" title="Telomerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">telomerase</a>, which is required for the replication of telomeres.<sup id="cite_ref-Greider_55-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Greider-55" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[55]</a></sup><sup id="cite_ref-118" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-118" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[118]</a></sup> Telomerase is an unusual polymerase because it contains its own RNA template as part of its structure.<sup id="cite_ref-Nugent_56-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Nugent-56" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[56]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Transcription is carried out by a DNA-dependent <a href="http://en.wikipedia.org/wiki/RNA_polymerase" title="RNA polymerase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase</a> that copies the sequence of a DNA strand into RNA. To begin transcribing a gene, the RNA polymerase binds to a sequence of DNA called a promoter and separates the DNA strands. It then copies the gene sequence into a <a href="http://en.wikipedia.org/wiki/Messenger_RNA" title="Messenger RNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">messenger RNA</a> transcript until it reaches a region of DNA called the<a href="http://en.wikipedia.org/wiki/Terminator_(genetics)" title="Terminator (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">terminator</a>, where it halts and detaches from the DNA. As with human DNA-dependent DNA polymerases, <a href="http://en.wikipedia.org/wiki/RNA_polymerase_II" title="RNA polymerase II" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA polymerase II</a>, the enzyme that transcribes most of the genes in the human genome, operates as part of a large <a href="http://en.wikipedia.org/wiki/Protein_complex" title="Protein complex" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">protein complex</a> with multiple regulatory and accessory subunits.<sup id="cite_ref-119" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-119" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[119]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Genetic_recombination">Genetic recombination</span></h2>
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<div class="thumbcaption" style="border: none; line-height: 1.4em; font-size: 12px; padding: 3px !important;">Structure of the <a href="http://en.wikipedia.org/wiki/Holliday_junction" title="Holliday junction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Holliday junction</a> intermediate in <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic recombination</a>. The four separate DNA strands are coloured red, blue, green and yellow.<sup id="cite_ref-120" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-120" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[120]</a></sup></div>
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<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic recombination</a></div>
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<div class="thumbinner" style="min-width: 100px; border: 1px solid rgb(204, 204, 204); background-color: rgb(249, 249, 249); font-size: 12px; text-align: center; overflow: hidden; width: 252px; padding: 3px !important;"><a href="http://en.wikipedia.org/wiki/File:Chromosomal_Recombination.svg" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Chromosomal_Recombination.svg/250px-Chromosomal_Recombination.svg.png" width="250" height="162" class="thumbimage" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Chromosomal_Recombination.svg/375px-Chromosomal_Recombination.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b2/Chromosomal_Recombination.svg/500px-Chromosomal_Recombination.svg.png 2x" style="border: 1px solid rgb(204, 204, 204); vertical-align: middle; background-color: rgb(255, 255, 255);" /></a>
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<div class="magnify" style="margin-left: 3px; float: right; border: none !important; background-image: none !important;"><a href="http://en.wikipedia.org/wiki/File:Chromosomal_Recombination.svg" class="internal" title="Enlarge" style="text-decoration: none; color: rgb(11, 0, 128); display: block; background-image: none !important; border: none !important;"><img src="http://bits.wikimedia.org/static-1.22wmf12/skins/common/images/magnify-clip.png" width="15" height="11" alt="" style="vertical-align: middle; display: block; border: none !important; background-image: none !important;" /></a></div>
Recombination involves the breakage and rejoining of two chromosomes (M and F) to produce two re-arranged chromosomes (C1 and C2).</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">A DNA helix usually does not interact with other segments of DNA, and in human cells the different chromosomes even occupy separate areas in the nucleus called "chromosome territories".<sup id="cite_ref-121" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-121" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[121]</a></sup> This physical separation of different chromosomes is important for the ability of DNA to function as a stable repository for information, as one of the few times chromosomes interact is during <a href="http://en.wikipedia.org/wiki/Chromosomal_crossover" title="Chromosomal crossover" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomal crossover</a> when they <a href="http://en.wikipedia.org/wiki/Genetic_recombination" title="Genetic recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">recombine</a>. Chromosomal crossover is when two DNA helices break, swap a section and then rejoin.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Recombination allows chromosomes to exchange genetic information and produces new combinations of genes, which increases the efficiency of <a href="http://en.wikipedia.org/wiki/Natural_selection" title="Natural selection" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">natural selection</a> and can be important in the rapid evolution of new proteins.<sup id="cite_ref-122" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-122" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[122]</a></sup> Genetic recombination can also be involved in DNA repair, particularly in the cell's response to double-strand breaks.<sup id="cite_ref-123" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-123" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[123]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The most common form of chromosomal crossover is <a href="http://en.wikipedia.org/wiki/Homologous_recombination" title="Homologous recombination" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">homologous recombination</a>, where the two chromosomes involved share very similar sequences. Non-homologous recombination can be damaging to cells, as it can produce <a href="http://en.wikipedia.org/wiki/Chromosomal_translocation" title="Chromosomal translocation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">chromosomal translocations</a>and genetic abnormalities. The recombination reaction is catalyzed by enzymes known as <a href="http://en.wikipedia.org/wiki/Recombinase" title="Recombinase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">recombinases</a>, such as <a href="http://en.wikipedia.org/wiki/RAD51" title="RAD51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RAD51</a>.<sup id="cite_ref-124" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-124" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[124]</a></sup> The first step in recombination is a double-stranded break caused by either an <a href="http://en.wikipedia.org/wiki/Endonuclease" title="Endonuclease" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">endonuclease</a> or damage to the DNA.<sup id="cite_ref-125" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-125" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[125]</a></sup> A series of steps catalyzed in part by the recombinase then leads to joining of the two helices by at least one <a href="http://en.wikipedia.org/wiki/Holliday_junction" title="Holliday junction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Holliday junction</a>, in which a segment of a single strand in each helix is annealed to the complementary strand in the other helix. The Holliday junction is a tetrahedral junction structure that can be moved along the pair of chromosomes, swapping one strand for another. The recombination reaction is then halted by cleavage of the junction and re-ligation of the released DNA.<sup id="cite_ref-126" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-126" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[126]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Evolution">Evolution</span></h2>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/RNA_world_hypothesis" title="RNA world hypothesis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA world hypothesis</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA contains the genetic information that allows all modern living things to function, grow and reproduce. However, it is unclear how long in the 4-billion-year <a href="http://en.wikipedia.org/wiki/Timeline_of_evolution" title="Timeline of evolution" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">history of life</a> DNA has performed this function, as it has been proposed that the earliest forms of life may have used RNA as their genetic material.<sup id="cite_ref-autogenerated1_127-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-autogenerated1-127" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[127]</a></sup><sup id="cite_ref-128" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-128" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[128]</a></sup> RNA may have acted as the central part of early <a href="http://en.wikipedia.org/wiki/Cell_metabolism" title="Cell metabolism" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">cell metabolism</a> as it can both transmit genetic information and carry out <a href="http://en.wikipedia.org/wiki/Catalysis" title="Catalysis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">catalysis</a> as part of <a href="http://en.wikipedia.org/wiki/Ribozyme" title="Ribozyme" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ribozymes</a>.<sup id="cite_ref-129" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-129" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[129]</a></sup> This ancient <a href="http://en.wikipedia.org/wiki/RNA_world_hypothesis" title="RNA world hypothesis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">RNA world</a> where nucleic acid would have been used for both catalysis and genetics may have influenced the <a href="http://en.wikipedia.org/wiki/Evolution" title="Evolution" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">evolution</a> of the current genetic code based on four nucleotide bases. This would occur, since the number of different bases in such an organism is a trade-off between a small number of bases increasing replication accuracy and a large number of bases increasing the catalytic efficiency of ribozymes.<sup id="cite_ref-130" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-130" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[130]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">However, there is no direct evidence of ancient genetic systems, as recovery of DNA from most fossils is impossible. This is because DNA survives in the environment for less than one million years, and slowly degrades into short fragments in solution.<sup id="cite_ref-131" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-131" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[131]</a></sup> Claims for older DNA have been made, most notably a report of the isolation of a viable bacterium from a salt crystal 250 million years old,<sup id="cite_ref-132" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-132" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[132]</a></sup> but these claims are controversial.<sup id="cite_ref-133" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-133" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[133]</a></sup><sup id="cite_ref-134" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-134" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[134]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">On 8 August 2011, a report, based on <a href="http://en.wikipedia.org/wiki/NASA" title="NASA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">NASA</a> studies with <a href="http://en.wikipedia.org/wiki/Meteorites" title="Meteorites" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">meteorites</a> found on <a href="http://en.wikipedia.org/wiki/Earth" title="Earth" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Earth</a>, was published suggesting building blocks of DNA (<a href="http://en.wikipedia.org/wiki/Adenine" title="Adenine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">adenine</a>, <a href="http://en.wikipedia.org/wiki/Guanine" title="Guanine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">guanine</a> and related <a href="http://en.wikipedia.org/wiki/Organic_molecules" title="Organic molecules" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">organic molecules</a>) may have been formed extraterrestrially in <a href="http://en.wikipedia.org/wiki/Outer_space" title="Outer space" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">outer space</a>.<sup id="cite_ref-Callahan_135-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Callahan-135" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[135]</a></sup><sup id="cite_ref-Steigerwald_136-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Steigerwald-136" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[136]</a></sup><sup id="cite_ref-DNA_137-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-DNA-137" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[137]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Uses_in_technology">Uses in technology</span></h2>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Genetic_engineering">Genetic engineering</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Molecular_biology" title="Molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular biology</a>, <a href="http://en.wikipedia.org/wiki/Nucleic_acid_methods" title="Nucleic acid methods" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleic acid methods</a> and <a href="http://en.wikipedia.org/wiki/Genetic_engineering" title="Genetic engineering" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic engineering</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Methods have been developed to purify DNA from organisms, such as <a href="http://en.wikipedia.org/wiki/Phenol-chloroform_extraction" title="Phenol-chloroform extraction" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phenol-chloroform extraction</a>, and to manipulate it in the laboratory, such as <a href="http://en.wikipedia.org/wiki/Restriction_digest" title="Restriction digest" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">restriction digests</a> and the<a href="http://en.wikipedia.org/wiki/Polymerase_chain_reaction" title="Polymerase chain reaction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polymerase chain reaction</a>. Modern <a href="http://en.wikipedia.org/wiki/Biology" title="Biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">biology</a> and <a href="http://en.wikipedia.org/wiki/Biochemistry" title="Biochemistry" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">biochemistry</a> make intensive use of these techniques in recombinant DNA technology. <a href="http://en.wikipedia.org/wiki/Recombinant_DNA" title="Recombinant DNA" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Recombinant DNA</a> is a man-made DNA sequence that has been assembled from other DNA sequences. They can be <a href="http://en.wikipedia.org/wiki/Transformation_(genetics)" title="Transformation (genetics)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transformed</a> into organisms in the form of <a href="http://en.wikipedia.org/wiki/Plasmid" title="Plasmid" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">plasmids</a> or in the appropriate format, by using a <a href="http://en.wikipedia.org/wiki/Viral_vector" title="Viral vector" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">viral vector</a>.<sup id="cite_ref-138" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-138" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[138]</a></sup> The <a href="http://en.wikipedia.org/wiki/Genetic_engineering" title="Genetic engineering" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetically modified</a> organisms produced can be used to produce products such as recombinant <a href="http://en.wikipedia.org/wiki/Protein" title="Protein" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">proteins</a>, used in <a href="http://en.wikipedia.org/wiki/Medical_research" title="Medical research" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">medical research</a>,<sup id="cite_ref-139" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-139" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[139]</a></sup> or be grown in<a href="http://en.wikipedia.org/wiki/Agriculture" title="Agriculture" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">agriculture</a>.<sup id="cite_ref-140" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-140" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[140]</a></sup><sup id="cite_ref-141" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-141" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[141]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Forensics">Forensics</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_profiling" title="DNA profiling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA profiling</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Forensic_science" title="Forensic science" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Forensic scientists</a> can use DNA in <a href="http://en.wikipedia.org/wiki/Blood" title="Blood" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">blood</a>, <a href="http://en.wikipedia.org/wiki/Semen" title="Semen" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">semen</a>, <a href="http://en.wikipedia.org/wiki/Skin" title="Skin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">skin</a>, <a href="http://en.wikipedia.org/wiki/Saliva" title="Saliva" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">saliva</a> or <a href="http://en.wikipedia.org/wiki/Hair" title="Hair" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">hair</a> found at a <a href="http://en.wikipedia.org/wiki/Crime_scene" title="Crime scene" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">crime scene</a> to identify a matching DNA of an individual, such as a perpetrator. This process is formally termed <a href="http://en.wikipedia.org/wiki/DNA_profiling" title="DNA profiling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA profiling</a>, but may also be called "<a href="http://en.wikipedia.org/wiki/Genetic_fingerprinting" title="Genetic fingerprinting" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic fingerprinting</a>". In DNA profiling, the lengths of variable sections of repetitive DNA, such as <a href="http://en.wikipedia.org/wiki/Short_tandem_repeat" title="Short tandem repeat" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">short tandem repeats</a> and <a href="http://en.wikipedia.org/wiki/Minisatellite" title="Minisatellite" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">minisatellites</a>, are compared between people. This method is usually an extremely reliable technique for identifying a matching DNA.<sup id="cite_ref-142" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-142" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[142]</a></sup> However, identification can be complicated if the scene is contaminated with DNA from several people.<sup id="cite_ref-143" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-143" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[143]</a></sup> DNA profiling was developed in 1984 by British geneticist Sir <a href="http://en.wikipedia.org/wiki/Alec_Jeffreys" title="Alec Jeffreys" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Alec Jeffreys</a>,<sup id="cite_ref-144" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-144" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[144]</a></sup> and first used in forensic science to convict Colin Pitchfork in the 1988 <a href="http://en.wikipedia.org/wiki/Colin_Pitchfork" title="Colin Pitchfork" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Enderby murders</a> case.<sup id="cite_ref-145" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-145" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[145]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">The development of forensic science, and the ability to now obtain genetic matching on minute samples of blood, skin, saliva or hair has led to a re-examination of a number of cases. Evidence can now be uncovered that was not scientifically possible at the time of the original examination. Combined with the removal of the <a href="http://en.wikipedia.org/wiki/Double_jeopardy" title="Double jeopardy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">double jeopardy</a> law in some places, this can allow cases to be reopened where previous trials have failed to produce sufficient evidence to convince a jury. People charged with serious crimes may be required to provide a sample of DNA for matching purposes. The most obvious defence to DNA matches obtained forensically is to claim that cross-contamination of evidence has taken place. This has resulted in meticulous strict handling procedures with new cases of serious crime. DNA profiling is also used to identify victims of mass casualty incidents.<sup id="cite_ref-146" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-146" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[146]</a></sup> As well as positively identifying bodies or body parts in serious accidents, DNA profiling is being successfully used to identify individual victims in mass war graves – matching to family members.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Bioinformatics">Bioinformatics</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Bioinformatics" title="Bioinformatics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bioinformatics</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;"><a href="http://en.wikipedia.org/wiki/Bioinformatics" title="Bioinformatics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bioinformatics</a> involves the manipulation, searching, and <a href="http://en.wikipedia.org/wiki/Data_mining" title="Data mining" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">data mining</a> of biological data, and this includes DNA sequence data. The development of techniques to store and search DNA sequences have led to widely applied advances in <a href="http://en.wikipedia.org/wiki/Computer_science" title="Computer science" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">computer science</a>, especially <a href="http://en.wikipedia.org/wiki/String_searching_algorithm" title="String searching algorithm" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">string searching algorithms</a>, <a href="http://en.wikipedia.org/wiki/Machine_learning" title="Machine learning" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">machine learning</a> and <a href="http://en.wikipedia.org/wiki/Database_theory" title="Database theory" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">database theory</a>.<sup id="cite_ref-147" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-147" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[147]</a></sup> String searching or matching algorithms, which find an occurrence of a sequence of letters inside a larger sequence of letters, were developed to search for specific sequences of nucleotides.<sup id="cite_ref-148" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-148" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[148]</a></sup> The DNA sequence may be <a href="http://en.wikipedia.org/wiki/Sequence_alignment" title="Sequence alignment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">aligned</a> with other DNA sequences to identify <a href="http://en.wikipedia.org/wiki/Homology_(biology)" title="Homology (biology)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">homologous</a> sequences and locate the specific <a href="http://en.wikipedia.org/wiki/Mutation" title="Mutation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">mutations</a> that make them distinct. These techniques, especially<a href="http://en.wikipedia.org/wiki/Multiple_sequence_alignment" title="Multiple sequence alignment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">multiple sequence alignment</a>, are used in studying <a href="http://en.wikipedia.org/wiki/Phylogenetics" title="Phylogenetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phylogenetic</a> relationships and protein function.<sup id="cite_ref-149" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-149" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[149]</a></sup> Data sets representing entire genomes' worth of DNA sequences, such as those produced by the <a href="http://en.wikipedia.org/wiki/Human_Genome_Project" title="Human Genome Project" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Human Genome Project</a>, are difficult to use without the annotations that identify the locations of genes and regulatory elements on each chromosome. Regions of DNA sequence that have the characteristic patterns associated with protein- or RNA-coding genes can be identified by <a href="http://en.wikipedia.org/wiki/Gene_prediction" title="Gene prediction" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene finding</a> algorithms, which allow researchers to predict the presence of particular <a href="http://en.wikipedia.org/wiki/Gene_product" title="Gene product" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gene products</a> and their possible functions in an organism even before they have been isolated experimentally.<sup id="cite_ref-Mount_150-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Mount-150" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[150]</a></sup> Entire genomes may also be compared, which can shed light on the evolutionary history of particular organism and permit the examination of complex evolutionary events.</p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="DNA_nanotechnology">DNA nanotechnology</span></h3>
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<div class="thumbinner" style="min-width: 100px; border: 1px solid rgb(204, 204, 204); background-color: rgb(249, 249, 249); font-size: 12px; text-align: center; overflow: hidden; width: 402px; padding: 3px !important;"><a href="http://en.wikipedia.org/wiki/File:DNA_nanostructures.png" class="image" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><img alt="" src="http://upload.wikimedia.org/wikipedia/commons/thumb/5/55/DNA_nanostructures.png/400px-DNA_nanostructures.png" width="400" height="220" class="thumbimage" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/55/DNA_nanostructures.png/600px-DNA_nanostructures.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/55/DNA_nanostructures.png/800px-DNA_nanostructures.png 2x" style="border: 1px solid rgb(204, 204, 204); vertical-align: middle; background-color: rgb(255, 255, 255);" /></a>
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<div class="magnify" style="margin-left: 3px; float: right; border: none !important; background-image: none !important;"><a href="http://en.wikipedia.org/wiki/File:DNA_nanostructures.png" class="internal" title="Enlarge" style="text-decoration: none; color: rgb(11, 0, 128); display: block; background-image: none !important; border: none !important;"><img src="http://bits.wikimedia.org/static-1.22wmf12/skins/common/images/magnify-clip.png" width="15" height="11" alt="" style="vertical-align: middle; display: block; border: none !important; background-image: none !important;" /></a></div>
The DNA structure at left (schematic shown) will self-assemble into the structure visualized by <a href="http://en.wikipedia.org/wiki/Atomic_force_microscope" title="Atomic force microscope" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">atomic force microscopy</a> at right. <a href="http://en.wikipedia.org/wiki/DNA_nanotechnology" title="DNA nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA nanotechnology</a> is the field that seeks to design nanoscale structures using the <a href="http://en.wikipedia.org/wiki/Molecular_recognition" title="Molecular recognition" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular recognition</a> properties of DNA molecules. Image from<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1371/journal.pbio.0020073" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Strong, 2004</a>.</div>
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<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/DNA_nanotechnology" title="DNA nanotechnology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA nanotechnology</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA nanotechnology uses the unique <a href="http://en.wikipedia.org/wiki/Molecular_recognition" title="Molecular recognition" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">molecular recognition</a> properties of DNA and other nucleic acids to create self-assembling branched DNA complexes with useful properties.<sup id="cite_ref-151" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-151" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[151]</a></sup> DNA is thus used as a structural material rather than as a carrier of biological information. This has led to the creation of two-dimensional periodic lattices (both tile-based as well as using the "<a href="http://en.wikipedia.org/wiki/DNA_origami" title="DNA origami" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA origami</a>" method) as well as three-dimensional structures in the shapes of <a href="http://en.wikipedia.org/wiki/Polyhedron" title="Polyhedron" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">polyhedra</a>.<sup id="cite_ref-152" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-152" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[152]</a></sup> <a href="http://en.wikipedia.org/wiki/DNA_machine" title="DNA machine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nanomechanical devices</a> and <a href="http://en.wikipedia.org/wiki/DNA_computing" title="DNA computing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">algorithmic self-assembly</a> have also been demonstrated,<sup id="cite_ref-153" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-153" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[153]</a></sup> and these DNA structures have been used to template the arrangement of other molecules such as <a href="http://en.wikipedia.org/wiki/Colloidal_gold" title="Colloidal gold" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">gold nanoparticles</a> and <a href="http://en.wikipedia.org/wiki/Streptavidin" title="Streptavidin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">streptavidin</a> proteins.<sup id="cite_ref-154" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-154" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[154]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="History_and_anthropology">History and anthropology</span></h3>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/Phylogenetics" title="Phylogenetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Phylogenetics</a> and <a href="http://en.wikipedia.org/wiki/Genetic_genealogy" title="Genetic genealogy" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic genealogy</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Because DNA collects mutations over time, which are then inherited, it contains historical information, and, by comparing DNA sequences, geneticists can infer the evolutionary history of organisms, their <a href="http://en.wikipedia.org/wiki/Phylogenetics" title="Phylogenetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">phylogeny</a>.<sup id="cite_ref-155" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-155" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[155]</a></sup>This field of phylogenetics is a powerful tool in <a href="http://en.wikipedia.org/wiki/Evolutionary_biology" title="Evolutionary biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">evolutionary biology</a>. If DNA sequences within a species are compared, <a href="http://en.wikipedia.org/wiki/Population_genetics" title="Population genetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">population geneticists</a> can learn the history of particular populations. This can be used in studies ranging from <a href="http://en.wikipedia.org/wiki/Ecological_genetics" title="Ecological genetics" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ecological genetics</a> to <a href="http://en.wikipedia.org/wiki/Anthropology" title="Anthropology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">anthropology</a>; For example, DNA evidence is being used to try to identify the <a href="http://en.wikipedia.org/wiki/Ten_Lost_Tribes" title="Ten Lost Tribes" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Ten Lost Tribes of Israel</a>.<sup id="cite_ref-156" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-156" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[156]</a></sup><sup id="cite_ref-157" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-157" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[157]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA has also been used to look at modern family relationships, such as establishing family relationships between the descendants of <a href="http://en.wikipedia.org/wiki/Sally_Hemings" title="Sally Hemings" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Sally Hemings</a> and <a href="http://en.wikipedia.org/wiki/Thomas_Jefferson" title="Thomas Jefferson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Thomas Jefferson</a>. This usage is closely related to the use of DNA in criminal investigations detailed above. Indeed, some criminal investigations have been solved when DNA from crime scenes has matched relatives of the guilty individual.<sup id="cite_ref-158" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-158" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[158]</a></sup></p>
<h3 style="background-image: none; margin: 0px 0px 0.3em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-style: none; font-size: 16.799999237060547px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Information_storage">Information storage</span></h3>
<div class="rellink relarticle mainarticle" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Main article: <a href="http://en.wikipedia.org/wiki/DNA_digital_data_storage" title="DNA digital data storage" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA digital data storage</a></div>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In a paper published in Nature in January, 2013, scientists from the <a href="http://en.wikipedia.org/wiki/European_Bioinformatics_Institute" title="European Bioinformatics Institute" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">European Bioinformatics Institute</a> and <a href="http://en.wikipedia.org/wiki/Agilent_Technologies" title="Agilent Technologies" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Agilent Technologies</a> proposed a mechanism to use DNA's ability to code information as a means of digital data storage. The group was able to encode 739 kilobytes of data into DNA code, synthesize the actual DNA, then sequence the DNA and decode the information back to its original form, with a reported 100% accuracy. The encoded information consisted of text files and audio files. A prior experiment was published in August 2012. It was conducted by researchers at <a href="http://en.wikipedia.org/wiki/Harvard_University" title="Harvard University" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Harvard University</a>, where the text of a 54,000-word book was encoded in DNA.<sup id="cite_ref-159" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-159" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[159]</a></sup><sup id="cite_ref-160" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-160" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[160]</a></sup></p>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="History_of_DNA_research">History of DNA research</span></h2>
<div class="rellink boilerplate further" style="font-style: italic; padding-left: 1.6em; margin-bottom: 0.5em; font-family: sans-serif; font-size: 12.800000190734863px; line-height: 19.200000762939453px;">Further information: <a href="http://en.wikipedia.org/wiki/History_of_molecular_biology" title="History of molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">History of molecular biology</a></div>
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James Watson and Francis Crick (right), co-originators of the double-helix model, with Maclyn McCarty (left).</div>
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<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">DNA was first isolated by the Swiss physician <a href="http://en.wikipedia.org/wiki/Friedrich_Miescher" title="Friedrich Miescher" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Friedrich Miescher</a> who, in 1869, discovered a microscopic substance in the pus of discarded surgical bandages. As it resided in the nuclei of cells, he called it "nuclein".<sup id="cite_ref-161" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-161" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[161]</a></sup> In 1878, Albrecht Kossel isolated the non-protein component of "nuclein", nucleic acid, and later isolated its five primary <a href="http://en.wikipedia.org/wiki/Nucleobases" title="Nucleobases" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">nucleobases</a>.<sup id="cite_ref-Yale_Jones_1953_162-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Yale_Jones_1953-162" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[162]</a></sup> In 1919, Phoebus Levene identified the base, sugar and phosphate nucleotide unit.<sup id="cite_ref-163" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-163" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[163]</a></sup> Levene suggested that DNA consisted of a string of nucleotide units linked together through the phosphate groups. However, Levene thought the chain was short and the bases repeated in a fixed order. In 1937 <a href="http://en.wikipedia.org/wiki/William_Astbury" title="William Astbury" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">William Astbury</a> produced the first X-ray diffraction patterns that showed that DNA had a regular structure.<sup id="cite_ref-164" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-164" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[164]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In 1927, <a href="http://en.wikipedia.org/wiki/Nikolai_Koltsov" title="Nikolai Koltsov" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nikolai Koltsov</a> proposed that inherited traits would be inherited via a "giant hereditary molecule" made up of "two mirror strands that would replicate in a semi-conservative fashion using each strand as a template".<sup id="cite_ref-Soyfer_165-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-Soyfer-165" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[165]</a></sup> In 1928, <a href="http://en.wikipedia.org/wiki/Frederick_Griffith" title="Frederick Griffith" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Frederick Griffith</a> discovered that <a href="http://en.wikipedia.org/wiki/Trait_(biology)" title="Trait (biology)" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">traits</a> of the "smooth" form of <i>Pneumococcus</i> could be transferred to the "rough" form of the same bacteria by mixing killed "smooth" bacteria with the live "rough" form.<sup id="cite_ref-166" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-166" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[166]</a></sup> This system provided the first clear suggestion that DNA carries genetic information—the <a href="http://en.wikipedia.org/wiki/Avery%E2%80%93MacLeod%E2%80%93McCarty_experiment" title="Avery–MacLeod–McCarty experiment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Avery–MacLeod–McCarty experiment</a>—when <a href="http://en.wikipedia.org/wiki/Oswald_Avery" title="Oswald Avery" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Oswald Avery</a>, along with coworkers <a href="http://en.wikipedia.org/wiki/Colin_Munro_MacLeod" title="Colin Munro MacLeod" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Colin MacLeod</a> and <a href="http://en.wikipedia.org/wiki/Maclyn_McCarty" title="Maclyn McCarty" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Maclyn McCarty</a>, identified DNA as the <a href="http://en.wikipedia.org/wiki/Griffith%27s_experiment" title="Griffith's experiment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">transforming principle</a> in 1943.<sup id="cite_ref-167" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-167" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[167]</a></sup> DNA's role in <a href="http://en.wikipedia.org/wiki/Heredity" title="Heredity" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">heredity</a> was confirmed in 1952, when <a href="http://en.wikipedia.org/wiki/Alfred_Hershey" title="Alfred Hershey" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Alfred Hershey</a> and <a href="http://en.wikipedia.org/wiki/Martha_Chase" title="Martha Chase" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Martha Chase</a> in the <a href="http://en.wikipedia.org/wiki/Hershey%E2%80%93Chase_experiment" title="Hershey–Chase experiment" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Hershey–Chase experiment</a> showed that DNA is the <a href="http://en.wikipedia.org/wiki/Genetic_material" title="Genetic material" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">genetic material</a> of the <a href="http://en.wikipedia.org/wiki/Enterobacteria_phage_T2" title="Enterobacteria phage T2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">T2 phage</a>.<sup id="cite_ref-168" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-168" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[168]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In 1953, <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">James Watson</a> and <a href="http://en.wikipedia.org/wiki/Francis_Crick" title="Francis Crick" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Francis Crick</a> suggested what is now accepted as the first correct double-helix model of <a href="http://en.wikipedia.org/wiki/Molecular_structure_of_Nucleic_Acids" title="Molecular structure of Nucleic Acids" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA structure</a> in the journal <i><a href="http://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nature</a></i>.<sup id="cite_ref-FWPUB_5-2" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-FWPUB-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[5]</a></sup> Their double-helix, molecular model of DNA was then based on a single <a href="http://en.wikipedia.org/wiki/X-ray_diffraction" title="X-ray diffraction" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-ray diffraction</a> image (labeled as "<a href="http://en.wikipedia.org/wiki/Photo_51" title="Photo 51" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Photo 51</a>")<sup id="cite_ref-169" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-169" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[169]</a></sup> taken by <a href="http://en.wikipedia.org/wiki/Rosalind_Franklin" title="Rosalind Franklin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Rosalind Franklin</a> and <a href="http://en.wikipedia.org/wiki/Raymond_Gosling" title="Raymond Gosling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Raymond Gosling</a> in May 1952, as well as the information that the DNA bases are paired — also obtained through private communications from Erwin Chargaff in the previous years. <a href="http://en.wikipedia.org/wiki/Chargaff%27s_rules" title="Chargaff's rules" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Chargaff's rules</a> played a very important role in establishing double-helix configurations for B-DNA as well as A-DNA.</p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">Experimental evidence supporting the Watson and Crick model was published in a series of five articles in the same issue of <i>Nature</i>.<sup id="cite_ref-NatureDNA50_170-0" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatureDNA50-170" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[170]</a></sup> Of these, Franklin and Gosling's paper was the first publication of their own X-ray diffraction data and original analysis method that partially supported the Watson and Crick model;<sup id="cite_ref-NatFranGos_41-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatFranGos-41" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[41]</a></sup><sup id="cite_ref-171" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-171" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[171]</a></sup> this issue also contained an article on DNA structure by <a href="http://en.wikipedia.org/wiki/Maurice_Wilkins" title="Maurice Wilkins" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Maurice Wilkins</a> and two of his colleagues, whose analysis and <i>in vivo</i> B-DNA X-ray patterns also supported the presence <i>in vivo</i> of the double-helical DNA configurations as proposed by Crick and Watson for their double-helix molecular model of DNA in the previous two pages of <i>Nature</i>.<sup id="cite_ref-NatWilk_42-1" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-NatWilk-42" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[42]</a></sup> In 1962, after Franklin's death, Watson, Crick, and Wilkins jointly received the Nobel Prize in <a href="http://en.wikipedia.org/wiki/Nobel_Prize_in_Physiology_or_Medicine" title="Nobel Prize in Physiology or Medicine" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Physiology or Medicine</a>.<sup id="cite_ref-172" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-172" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[172]</a></sup> Nobel Prizes were awarded only to living recipients at the time. A debate continues about who should receive credit for the discovery.<sup id="cite_ref-173" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-173" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[173]</a></sup></p>
<p style="margin: 0.4em 0px 0.5em; line-height: 19.200000762939453px; font-family: sans-serif; font-size: 12.800000190734863px;">In an influential presentation in 1957, Crick laid out the <a href="http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology" title="Central dogma of molecular biology" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">central dogma of molecular biology</a>, which foretold the relationship between DNA, RNA, and proteins, and articulated the "adaptor hypothesis".<sup id="cite_ref-174" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-174" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[174]</a></sup> Final confirmation of the replication mechanism that was implied by the double-helical structure followed in 1958 through the Meselson–Stahl experiment.<sup id="cite_ref-175" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-175" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[175]</a></sup> Further work by Crick and coworkers showed that the genetic code was based on non-overlapping triplets of bases, called codons, allowing <a href="http://en.wikipedia.org/wiki/Har_Gobind_Khorana" title="Har Gobind Khorana" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Har Gobind Khorana</a>, <a href="http://en.wikipedia.org/wiki/Robert_W._Holley" title="Robert W. Holley" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Robert W. Holley</a> and <a href="http://en.wikipedia.org/wiki/Marshall_Warren_Nirenberg" title="Marshall Warren Nirenberg" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Marshall Warren Nirenberg</a> to decipher the genetic code.<sup id="cite_ref-176" class="reference" style="line-height: 1em; unicode-bidi: -webkit-isolate;"><a href="http://en.wikipedia.org/wiki/DNA#cite_note-176" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none; white-space: nowrap;">[176]</a></sup> These findings represent the birth of molecular biology.</p>
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<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="See_also">See also</span></h2>
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<td style="padding: 0px 0.2em; vertical-align: middle; font-style: italic; font-weight: bold;"><a href="http://en.wikipedia.org/wiki/Portal:Molecular_and_Cellular_Biology" title="Portal:Molecular and Cellular Biology" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Molecular and Cellular Biology portal</a></td>
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<ul style="line-height: 1.5em; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=);">
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Autosome" title="Autosome" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Autosome</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Crystallography" title="Crystallography" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Crystallography</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/DNA-encoded_chemical_library" title="DNA-encoded chemical library" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA-encoded chemical library</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/DNA_microarray" title="DNA microarray" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA microarray</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/DNA_sequencing" title="DNA sequencing" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">DNA sequencing</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Genetic_disorder" title="Genetic disorder" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Genetic disorder</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Haplotype" title="Haplotype" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Haplotype</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/List_of_nucleic_acid_simulation_software" title="List of nucleic acid simulation software" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">List of nucleic acid simulation software</a>- Nucleic acid modeling</li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Meiosis" title="Meiosis" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Meiosis</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Nucleic_acid_double_helix" title="Nucleic acid double helix" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nucleic acid double helix</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Nucleic_acid_notation" title="Nucleic acid notation" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nucleic acid notation</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Phosphoramidite" title="Phosphoramidite" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Phosphoramidite</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Southern_blot" title="Southern blot" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Southern blot</a></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/X-ray_scattering_techniques" title="X-ray scattering techniques" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">X-ray scattering techniques</a></li>
<li style="margin-bottom: 0.1em;"><i><a href="http://en.wikipedia.org/wiki/Proteopedia" title="Proteopedia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA</a></i></li>
</ul>
</div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="References">References</span></h2>
<div class="reflist references-column-width" style="font-size: 11.199999809265137px; margin-bottom: 0.5em; font-family: sans-serif; line-height: 19.200000762939453px; -webkit-column-width: 30em; list-style-type: decimal;">
<ol class="references" style="line-height: 1.5em; margin: 0.3em 0px 0.5em 3.2em; padding: 0px; list-style-image: none; list-style-type: inherit;">
<li id="cite_note-1" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Russell, Peter (2001). <i>iGenetics</i>. New York: Benjamin Cummings. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-8053-4553-1" title="Special:BookSources/0-8053-4553-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-8053-4553-1</a>.</span></span></li>
<li id="cite_note-2" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Saenger, Wolfram (1984). <i>Principles of Nucleic Acid Structure</i>. New York: Springer-Verlag. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-387-90762-9" title="Special:BookSources/0-387-90762-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-387-90762-9</a>.</span></span></li>
<li id="cite_note-Alberts-3" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Alberts_3-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Alberts_3-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Alberts, Bruce; Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walters (2002).<i>Molecular Biology of the Cell; Fourth Edition</i>. New York and London: Garland Science. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-8153-3218-1" title="Special:BookSources/0-8153-3218-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-8153-3218-1</a>.<a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/145080076+48122761+57023651+69932405" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">145080076 48122761 57023651 69932405</a>.</span></span></li>
<li id="cite_note-Butler-4" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Butler_4-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Butler, John M. (2001). <i>Forensic DNA Typing</i>. Elsevier.<a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/978-0-12-147951-0" title="Special:BookSources/978-0-12-147951-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">978-0-12-147951-0</a>. <a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/223032110+45406517" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">223032110 45406517</a>.</span>pp. 14–15.</span></li>
<li id="cite_note-FWPUB-5" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-FWPUB_5-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-FWPUB_5-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-FWPUB_5-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>c</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Watson J.D. and Crick F.H.C. (1953). <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/watsoncrick.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A Structure for Deoxyribose Nucleic Acid"</a> (PDF). <i>Nature</i> <b>171</b>(4356): 737–738. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..737W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..737W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171737a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171737a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054692" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054692</a>.</span></span></li>
<li id="cite_note-6" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Mandelkern M, Elias J, Eden D, Crothers D (1981). "The dimensions of DNA in solution". <i>J Mol Biol</i> <b>152</b> (1): 153–61. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2F0022-2836%2881%2990099-1" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/0022-2836(81)90099-1</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7338906" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7338906</a>.</span></span></li>
<li id="cite_note-7" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Gregory S; Barlow, KF; McLay, KE; Kaul, R; Swarbreck, D; Dunham, A; Scott, CE; Howe, KL; Woodfine, K (2006). "The DNA sequence and biological annotation of human chromosome 1". <i>Nature</i> <b>441</b> (7091): 315–21.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2006Natur.441..315G" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2006Natur.441..315G</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature04727" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature04727</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16710414" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16710414</a>.</span></span></li>
<li id="cite_note-autogenerated2-8" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-autogenerated2_8-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Watson J.D. and Crick F.H.C. (1953). <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/watsoncrick.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A Structure for Deoxyribose Nucleic Acid"</a> (PDF). <i>Nature</i> <b>171</b> (4356): 737–738. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..737W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..737W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171737a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171737a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054692" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054692</a><span class="reference-accessdate">. Retrieved 4 May 2009</span>.</span></span></li>
<li id="cite_note-berg-9" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-berg_9-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-berg_9-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-berg_9-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>c</b></i></sup></a></span> <span class="reference-text">Berg J., Tymoczko J. and Stryer L. (2002)<i>Biochemistry.</i> W. H. Freeman and Company <a href="http://en.wikipedia.org/wiki/Special:BookSources/0716749556" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-7167-4955-6</a></span></li>
<li id="cite_note-IUPAC-10" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-IUPAC_10-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/misc/naabb.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Abbreviations and Symbols for Nucleic Acids, Polynucleotides and their Constituents</a> IUPAC-IUB Commission on Biochemical Nomenclature (CBN). Retrieved 3 January 2006.</span></li>
<li id="cite_note-Ghosh-11" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Ghosh_11-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Ghosh_11-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Ghosh A, Bansal M (2003). "A glossary of DNA structures from A to Z". <i>Acta Crystallogr D</i> <b>59</b> (4): 620–6.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0907444903003251" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0907444903003251</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12657780" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12657780</a>.</span></span></li>
<li id="cite_note-12" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-12" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1D65" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">PDB 1D65</a></span></li>
<li id="cite_note-Yakovchuk2006-13" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Yakovchuk2006_13-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Yakovchuk P, Protozanova E, Frank-Kamenetskii MD (2006). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360284" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Base-stacking and base-pairing contributions into thermal stability of the DNA double helix"</a>. <i>Nucleic Acids Res.</i> <b>34</b> (2): 564–74. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fnar%2Fgkj454" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/nar/gkj454</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360284" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1360284</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16449200" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16449200</a>.</span></span></li>
<li id="cite_note-14" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-14" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Verma S, Eckstein F (1998). "Modified oligonucleotides: synthesis and strategy for users". <i>Annu. Rev. Biochem.</i><b>67</b>: 99–134. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.biochem.67.1.99" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.biochem.67.1.99</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9759484" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9759484</a>.</span></span></li>
<li id="cite_note-Kiljunen2005-15" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Kiljunen2005_15-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Kiljunen S, Hakala K, Pinta E, Huttunen S, Pluta P, Gador A, Lönnberg H, Skurnik M (2005). "Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine".<i>Microbiology</i> <b>151</b> (12): 4093–4102.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1099%2Fmic.0.28265-0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1099/mic.0.28265-0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16339954" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16339954</a>.</span></span></li>
<li id="cite_note-Simpson1998-16" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Simpson1998_16-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Simpson L (1998). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33841" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A base called J"</a>. <i>Proc Natl Acad Sci USA</i> <b>95</b> (5): 2037–2038.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.95.5.2037" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.95.5.2037</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33841" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">33841</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9482833" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9482833</a>.</span></span></li>
<li id="cite_note-Borst2008-17" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Borst2008_17-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Borst P, Sabatini R (2008). "Base J: discovery, biosynthesis, and possible functions". <i>Annual review of microbiology</i> <b>62</b>: 235–51.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.micro.62.081307.162750" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.micro.62.081307.162750</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/18729733" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">18729733</a>.</span></span></li>
<li id="cite_note-Cross1999-18" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Cross1999_18-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Cross M, Kieft R, Sabatini R, Wilm M, de Kort M, der Marel GA, van Boom JH, van Leeuwen F, Borst P <i>et al.</i>(1999). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171720" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans"</a>. <i>EMBO J</i> <b>18</b>(22): 6573–6581. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Femboj%2F18.22.6573" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/emboj/18.22.6573</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171720" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1171720</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10562569" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10562569</a>.</span></span></li>
<li id="cite_note-DiPaolo2005-19" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-DiPaolo2005_19-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">DiPaolo C, Kieft R, Cross M, Sabatini R (2005). "Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein". <i>Mol Cell</i> <b>17</b> (3): 441–451.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.molcel.2004.12.022" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.molcel.2004.12.022</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15694344" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">15694344</a>.</span></span></li>
<li id="cite_note-Vainio2009-20" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Vainio2009_20-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Vainio S, Genest PA, ter Riet B, van Luenen H, Borst P (2009). "Evidence that J-binding protein 2 is a thymidine hydroxylase catalyzing the first step in the biosynthesis of DNA base J". <i>Molecular and biochemical parasitology</i> <b>164</b>(2): 157–61. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.molbiopara.2008.12.001" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.molbiopara.2008.12.001</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19114062" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19114062</a>.</span></span></li>
<li id="cite_note-Iyer2009-21" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Iyer2009_21-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Iyer LM, Tahiliani M, Rao A, Aravind L (2009). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995806" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids"</a>.<i>Cell Cycle</i> <b>8</b> (11): 1698–1710.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.4161%2Fcc.8.11.8580" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.4161/cc.8.11.8580</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995806" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2995806</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19411852" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19411852</a>.</span></span></li>
<li id="cite_note-van_Luenen2012-22" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-van_Luenen2012_22-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A <i>et al.</i>(2012). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684241" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Leishmania"</a>. <i>Cell</i> <b>150</b> (5): 909–921.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.cell.2012.07.030" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.cell.2012.07.030</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684241" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">3684241</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/22939620" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">22939620</a>.</span></span></li>
<li id="cite_note-Hazelbaker2012-23" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Hazelbaker2012_23-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Hazelbaker DZ, Buratowski S (2012). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648658" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Transcription: base J blocks the way"</a>. <i>Curr Biol</i> <b>22</b> (22): R960–2.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.cub.2012.10.010" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.cub.2012.10.010</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648658" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">3648658</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/23174300" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">23174300</a>.</span></span></li>
<li id="cite_note-24" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-24" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wing R, Drew H, Takano T, Broka C, Tanaka S, Itakura K, Dickerson R (1980). "Crystal structure analysis of a complete turn of B-DNA". <i>Nature</i> <b>287</b> (5784): 755–8.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1980Natur.287..755W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1980Natur.287..755W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F287755a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/287755a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7432492" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7432492</a>.</span></span></li>
<li id="cite_note-Pabo1984-25" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Pabo1984_25-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Pabo1984_25-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Pabo C, Sauer R (1984). "Protein-DNA recognition".<i>Annu Rev Biochem</i> <b>53</b>: 293–321.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.bi.53.070184.001453" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.bi.53.070184.001453</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/6236744" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">6236744</a>.</span></span></li>
<li id="cite_note-26" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-26" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Clausen-Schaumann H, Rief M, Tolksdorf C, Gaub H (2000). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1300792" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Mechanical stability of single DNA molecules"</a>.<i>Biophys J</i> <b>78</b> (4): 1997–2007.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2000BpJ....78.1997C" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2000BpJ....78.1997C</a>. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2FS0006-3495%2800%2976747-6" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/S0006-3495(00)76747-6</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1300792" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1300792</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10733978" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10733978</a>.</span></span></li>
<li id="cite_note-27" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-27" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Chalikian T, Völker J, Plum G, Breslauer K (1999). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22151" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A more unified picture for the thermodynamics of nucleic acid duplex melting: A characterization by calorimetric and volumetric techniques"</a>. <i>Proc Natl Acad Sci USA</i> <b>96</b> (14): 7853–8. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1999PNAS...96.7853C" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1999PNAS...96.7853C</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.96.14.7853" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.96.14.7853</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22151" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">22151</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10393911" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10393911</a>.</span></span></li>
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<li id="cite_note-35" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-35" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Lamb R, Horvath C (1991). "Diversity of coding strategies in influenza viruses". <i>Trends Genet</i> <b>7</b> (8): 261–6.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2F0168-9525%2891%2990326-L" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/0168-9525(91)90326-L</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/1771674" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1771674</a>.</span></span></li>
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<li id="cite_note-40" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-40" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Franklin RE, Gosling RG (6 March 1953). <a rel="nofollow" class="external text" href="http://web.archive.org/web/20070612083334/http://hekto.med.unc.edu:8080/CARTER/carter_WWW/Bioch_134/PDF_files/Franklin_Gossling.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The Structure of Sodium Thymonucleate Fibres I. The Influence of Water Content"</a>. <i>Acta Crystallogr</i> <b>6</b> (8–9): 673–7.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0365110X53001939" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0365110X53001939</a>. Archived from <a rel="nofollow" class="external text" href="http://hekto.med.unc.edu:8080/CARTER/carter_WWW/Bioch_134/PDF_files/Franklin_Gossling.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">the original</a> on 2007-06-12.</span><br />
<span class="citation journal" style="word-wrap: break-word;">Franklin RE, Gosling RG (1953). "The structure of sodium thymonucleate fibres. II. The cylindrically symmetrical Patterson function". <i>Acta Crystallogr</i> <b>6</b> (8–9): 678–85.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1107%2FS0365110X53001940" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1107/S0365110X53001940</a>.</span></span></li>
<li id="cite_note-NatFranGos-41" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatFranGos_41-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatFranGos_41-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Franklin, Rosalind and Gosling, Raymond (1953).<a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/franklingosling.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Molecular Configuration in Sodium Thymonucleate. Franklin R. and Gosling R.G"</a> (PDF). <i>Nature</i> <b>171</b>(4356): 740–1. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..740F" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..740F</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171740a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171740a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054694" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054694</a>.</span></span></li>
<li id="cite_note-NatWilk-42" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatWilk_42-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatWilk_42-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wilkins M.H.F., A.R. Stokes A.R. & Wilson, H.R. (1953). <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/wilkins.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Molecular Structure of Deoxypentose Nucleic Acids"</a> (PDF). <i>Nature</i> <b>171</b> (4356): 738–740.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1953Natur.171..738W" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1953Natur.171..738W</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F171738a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/171738a0</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/13054693" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">13054693</a>.</span></span></li>
<li id="cite_note-43" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-43" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Leslie AG, Arnott S, Chandrasekaran R, Ratliff RL (1980). "Polymorphism of DNA double helices". <i>J. Mol. Biol.</i> <b>143</b> (1): 49–72. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2F0022-2836%2880%2990124-2" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/0022-2836(80)90124-2</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7441761" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7441761</a>.</span></span></li>
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<li id="cite_note-arsenic_extremophile-51" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-arsenic_extremophile_51-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-arsenic_extremophile_51-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation news" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://www.bbc.co.uk/news/science-environment-11886943" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Arsenic-loving bacteria may help in hunt for alien life"</a>. <i>BBC News</i>. 2 December 2010<span class="reference-accessdate">. Retrieved 2 December 2010</span>.</span></span></li>
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<li id="cite_note-Nature-54" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Nature_54-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;"><Please add first missing authors to populate metadata.>, Cressey (3 October 2012). "'Arsenic-life' Bacterium Prefers Phosphorus after all". <i>Nature News</i>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnews.2012.11520" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/news.2012.11520</a>.</span></span></li>
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<li id="cite_note-Nugent-56" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Nugent_56-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Nugent_56-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Nugent_56-2" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>c</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Nugent C, Lundblad V (1998). "The telomerase reverse transcriptase: components and regulation". <i>Genes Dev</i> <b>12</b> (8): 1073–85. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1101%2Fgad.12.8.1073" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1101/gad.12.8.1073</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9553037" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9553037</a>.</span></span></li>
<li id="cite_note-57" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-57" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Wright W, Tesmer V, Huffman K, Levene S, Shay J (1997). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC316649" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Normal human chromosomes have long G-rich telomeric overhangs at one end"</a>. <i>Genes Dev</i> <b>11</b> (21): 2801–9. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1101%2Fgad.11.21.2801" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1101/gad.11.21.2801</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC316649" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">316649</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9353250" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9353250</a>.</span></span></li>
<li id="cite_note-58" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-58" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://ndbserver.rutgers.edu/atlas/xray/structures/U/ud0017/ud0017.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">NDB UD0017</a></span></li>
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<li id="cite_note-77" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-77" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Beckman KB, Ames BN (1997). "Oxidative decay of DNA". <i>J. Biol. Chem.</i> <b>272</b> (32): 19633–6.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1074%2Fjbc.272.32.19633" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1074/jbc.272.32.19633</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/9289489" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">9289489</a>.</span></span></li>
<li id="cite_note-78" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-78" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Valerie K, Povirk L (2003). "Regulation and mechanisms of mammalian double-strand break repair". <i>Oncogene</i> <b>22</b>(37): 5792–812. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fsj.onc.1206679" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/sj.onc.1206679</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12947387" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12947387</a>.</span></span></li>
<li id="cite_note-Weinberg-79" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Weinberg_79-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation news" style="word-wrap: break-word;">Johnson, George (28 December 2010). <a rel="nofollow" class="external text" href="http://www.nytimes.com/2010/12/28/health/28cancer.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Unearthing Prehistoric Tumors, and Debate"</a>. <i><a href="http://en.wikipedia.org/wiki/The_New_York_Times" title="The New York Times" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">The New York Times</a></i>. "If we lived long enough, sooner or later we all would get cancer."</span></span></li>
<li id="cite_note-80" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-80" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Alberts, B, Johnson A, Lewis J, et al. (2002). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/books/NBK26897/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The Preventable Causes of Cancer"</a>. <i>Molecular biology of the cell</i> (4th ed.). New York: Garland Science. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-8153-4072-9" title="Special:BookSources/0-8153-4072-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-8153-4072-9</a>. "A certain irreducible background incidence of cancer is to be expected regardless of circumstances: mutations can never be absolutely avoided, because they are an inescapable consequence of fundamental limitations on the accuracy of DNA replication, as discussed in Chapter 5. If a human could live long enough, it is inevitable that at least one of his or her cells would eventually accumulate a set of mutations sufficient for cancer to develop."</span></span></li>
<li id="cite_note-81" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-81" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Bernstein H, Payne CM, Bernstein C, Garewal H, Dvorak K (2008). Cancer and aging as consequences of un-repaired DNA damage. In: New Research on DNA Damages (Editors: Honoka Kimura and Aoi Suzuki) Nova Science Publishers, Inc., New York, Chapter 1, pp. 1-47. open access, but read only<a rel="nofollow" class="external free" href="https://www.novapublishers.com/catalog/product_info.php?products_id=43247" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAdUlEQVQYV2P4//8/Awxv3LThf0dXKxyD+DA5DEUg+tWrV2AaWTFcIboJyJrhCtGtRMcgebhpL2/4/v//Lvn//x+7IRjIfn8v+P/t055gxZgKPzaC8Y/nMYQVLpnM8f/zo3AqKfzyOOL/h/sh/59c9sBUSIyvAeRdJWjk4E//AAAAAElFTkSuQmCC); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">https://www.novapublishers.com/catalog/product_info.php?products_id=43247</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/1604565810" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 1604565810</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/9781604565812" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-1604565812</a></span></li>
<li id="cite_note-82" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-82" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Hoeijmakers JH (October 2009). "DNA damage, aging, and cancer". <i>N. Engl. J. Med.</i> <b>361</b> (15): 1475–85.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1056%2FNEJMra0804615" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1056/NEJMra0804615</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19812404" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19812404</a>.</span></span></li>
<li id="cite_note-83" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-83" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Freitas AA, de Magalhães JP (2011). "A review and appraisal of the DNA damage theory of ageing". <i>Mutat. Res.</i><b>728</b> (1–2): 12–22. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.mrrev.2011.05.001" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.mrrev.2011.05.001</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/21600302" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">21600302</a>.</span></span></li>
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<li id="cite_note-101" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-101" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Jenuwein T, Allis C (2001). "Translating the histone code". <i>Science</i> <b>293</b> (5532): 1074–80.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1126%2Fscience.1063127" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1126/science.1063127</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11498575" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11498575</a>.</span></span></li>
<li id="cite_note-102" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-102" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Ito T (2003). "Nucleosome assembly and remodelling".<i>Curr Top Microbiol Immunol</i>. Current Topics in Microbiology and Immunology <b>274</b>: 1–22. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1007%2F978-3-642-55747-7_1" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1007/978-3-642-55747-7_1</a>. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/978-3-540-44208-0" title="Special:BookSources/978-3-540-44208-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">978-3-540-44208-0</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12596902" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12596902</a>.</span></span></li>
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<li id="cite_note-105" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-105" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Iftode C, Daniely Y, Borowiec J (1999). "Replication protein A (RPA): the eukaryotic SSB". <i>Crit Rev Biochem Mol Biol</i> <b>34</b> (3): 141–80.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1080%2F10409239991209255" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1080/10409239991209255</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10473346" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10473346</a>.</span></span></li>
<li id="cite_note-106" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-106" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=1LMB" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">PDB 1LMB</a></span></li>
<li id="cite_note-107" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-107" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Myers L, Kornberg R (2000). "Mediator of transcriptional regulation". <i>Annu Rev Biochem</i> <b>69</b>: 729–49.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1146%2Fannurev.biochem.69.1.729" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1146/annurev.biochem.69.1.729</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/10966474" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10966474</a>.</span></span></li>
<li id="cite_note-108" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-108" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Spiegelman B, Heinrich R (2004). "Biological control through regulated transcriptional coactivators". <i>Cell</i> <b>119</b>(2): 157–67. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1016%2Fj.cell.2004.09.037" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1016/j.cell.2004.09.037</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/15479634" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">15479634</a>.</span></span></li>
<li id="cite_note-109" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-109" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Li Z, Van Calcar S, Qu C, Cavenee W, Zhang M, Ren B (2003). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166200" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells"</a>. <i>Proc Natl Acad Sci USA</i><b>100</b> (14): 8164–9. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2003PNAS..100.8164L" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2003PNAS..100.8164L</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.1332764100" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.1332764100</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166200" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">166200</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12808131" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12808131</a>.</span></span></li>
<li id="cite_note-110" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-110" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Created from <a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=1RVA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">PDB 1RVA</a></span></li>
<li id="cite_note-111" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-111" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Bickle T, Krüger D (1993). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372918" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Biology of DNA restriction"</a>.<i>Microbiol Rev</i> <b>57</b> (2): 434–50. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372918" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">372918</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/8336674" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">8336674</a>.</span></span></li>
<li id="cite_note-Doherty-112" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink">^ <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Doherty_112-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>a</b></i></sup></a> <a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Doherty_112-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;"><sup style="line-height: 1em;"><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Doherty A, Suh S (2000). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113121" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Structural and mechanistic conservation in DNA ligases"</a>. <i>Nucleic Acids Res</i> <b>28</b>(21): 4051–8. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fnar%2F28.21.4051" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/nar/28.21.4051</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC113121" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">113121</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11058099" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11058099</a>.</span></span></li>
<li id="cite_note-113" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-113" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Schoeffler A, Berger J (2005). "Recent advances in understanding structure-function relationships in the type II topoisomerase mechanism". <i>Biochem Soc Trans</i> <b>33</b> (Pt 6): 1465–70. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1042%2FBST20051465" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1042/BST20051465</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16246147" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16246147</a>.</span></span></li>
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<li id="cite_note-144" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-144" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Jeffreys A, Wilson V, Thein S (1985). "Individual-specific 'fingerprints' of human DNA". <i>Nature</i> <b>316</b> (6023): 76–9.<a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1985Natur.316...76J" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1985Natur.316...76J</a>. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F316076a0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/316076a0</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/2989708" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2989708</a>.</span></span></li>
<li id="cite_note-145" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-145" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://web.archive.org/web/20061214004903/http://www.forensic.gov.uk/forensic_t/inside/news/list_casefiles.php?case=1" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Colin Pitchfork — first murder conviction on DNA evidence also clears the prime suspect</a> Forensic Science Service Accessed 23 December 2006</span></li>
<li id="cite_note-146" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-146" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation web" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://massfatality.dna.gov/Introduction/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"DNA Identification in Mass Fatality Incidents"</a>. National Institute of Justice. September 2006.</span></span></li>
<li id="cite_note-147" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-147" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Pierre_Baldi" title="Pierre Baldi" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Baldi, Pierre</a>; Brunak, Soren (2001). <i>Bioinformatics: The Machine Learning Approach</i>. MIT Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/978-0-262-02506-5" title="Special:BookSources/978-0-262-02506-5" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">978-0-262-02506-5</a>. <a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/45951728" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">45951728</a>.</span></span></li>
<li id="cite_note-148" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-148" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Gusfield, Dan. <i>Algorithms on Strings, Trees, and Sequences: Computer Science and Computational Biology</i>.<a href="http://en.wikipedia.org/wiki/Cambridge_University_Press" title="Cambridge University Press" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Cambridge University Press</a>, 15 January 1997. <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780521585194" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-521-58519-4</a>.</span></li>
<li id="cite_note-149" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-149" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Sjölander K (2004). "Phylogenomic inference of protein molecular function: advances and challenges".<i>Bioinformatics</i> <b>20</b> (2): 170–9.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1093%2Fbioinformatics%2Fbth021" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1093/bioinformatics/bth021</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/14734307" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">14734307</a>.</span></span></li>
<li id="cite_note-Mount-150" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Mount_150-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation book" style="word-wrap: break-word;">Mount DM (2004). <i>Bioinformatics: Sequence and Genome Analysis</i> (2 ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-87969-712-1" title="Special:BookSources/0-87969-712-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-87969-712-1</a>.<a href="http://en.wikipedia.org/wiki/OCLC" title="OCLC" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">OCLC</a> <a rel="nofollow" class="external text" href="http://www.worldcat.org/oclc/55106399" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">55106399</a>.</span></span></li>
<li id="cite_note-151" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-151" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Rothemund PW (2006). "Folding DNA to create nanoscale shapes and patterns". <i>Nature</i> <b>440</b> (7082): 297–302. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2006Natur.440..297R" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2006Natur.440..297R</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature04586" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature04586</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16541064" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16541064</a>.</span></span></li>
<li id="cite_note-152" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-152" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Andersen ES, Dong M, Nielsen MM (2009). "Self-assembly of a nanoscale DNA box with a controllable lid".<i>Nature</i> <b>459</b> (7243): 73–6. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/2009Natur.459...73A" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2009Natur.459...73A</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature07971" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature07971</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19424153" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19424153</a>.</span></span></li>
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<li id="cite_note-163" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-163" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Levene P, (1 December 1919). "The structure of yeast nucleic acid". <i>J Biol Chem</i> <b>40</b> (2): 415–24.</span></span></li>
<li id="cite_note-164" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-164" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Astbury W, (1947). "Nucleic acid". <i>Symp. SOC. Exp. Biol.</i> <b>1</b> (66).</span></span></li>
<li id="cite_note-Soyfer-165" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-Soyfer_165-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Valery N. Soyfer (2001). "The consequences of political dictatorship for Russian science". <i>Nature Reviews Genetics</i><b>2</b> (9): 723–729. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2F35088598" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/35088598</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/11533721" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">11533721</a>.</span></span></li>
<li id="cite_note-166" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-166" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Lorenz MG, Wackernagel W (1994). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372978" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Bacterial gene transfer by natural genetic transformation in the environment"</a>. <i>Microbiol. Rev.</i> <b>58</b> (3): 563–602.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372978" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">372978</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/7968924" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">7968924</a>.</span></span></li>
<li id="cite_note-167" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-167" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Avery O, MacLeod C, McCarty M (1944). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135445" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type Iii"</a>. <i>J Exp Med</i> <b>79</b>(2): 137–158. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1084%2Fjem.79.2.137" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1084/jem.79.2.137</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135445" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2135445</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/19871359" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">19871359</a>.</span></span></li>
<li id="cite_note-168" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-168" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Hershey A, Chase M (1952). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147348" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage"</a>. <i>J Gen Physiol</i> <b>36</b> (1): 39–56.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1085%2Fjgp.36.1.39" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1085/jgp.36.1.39</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147348" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">2147348</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12981234" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12981234</a>.</span></span></li>
<li id="cite_note-169" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-169" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">The B-DNA X-ray pattern <a rel="nofollow" class="external text" href="http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/pictures/sci9.001.5.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">on the right of this linked image</a> was obtained by <a href="http://en.wikipedia.org/wiki/Rosalind_Franklin" title="Rosalind Franklin" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Rosalind Franklin</a> and <a href="http://en.wikipedia.org/wiki/Raymond_Gosling" title="Raymond Gosling" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Raymond Gosling</a> in May 1952 at high hydration levels of DNA and it has been labeled as "Photo 51"</span></li>
<li id="cite_note-NatureDNA50-170" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-NatureDNA50_170-0" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Nature Archives <a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/archive.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Double Helix of DNA: 50 Years</a></span></li>
<li id="cite_note-171" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-171" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation web" style="word-wrap: break-word;"><a rel="nofollow" class="external text" href="http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/pictures/franklin-typeBphoto.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"Original X-ray diffraction image"</a>. Osulibrary.oregonstate.edu<span class="reference-accessdate">. Retrieved 6 February 2011</span>.</span></span></li>
<li id="cite_note-172" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-172" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://nobelprize.org/nobel_prizes/medicine/laureates/1962/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">The Nobel Prize in Physiology or Medicine 1962</a>Nobelprize .org Accessed 22 December 06</span></li>
<li id="cite_note-173" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-173" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Brenda Maddox (23 January 2003). <a rel="nofollow" class="external text" href="http://www.biomath.nyu.edu/index/course/hw_articles/nature4.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The double helix and the 'wronged heroine'"</a> (PDF). <i>Nature</i> <b>421</b> (6921): 407–408. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature01399" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature01399</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12540909" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12540909</a>.</span></span></li>
<li id="cite_note-174" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-174" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text">Crick, F.H.C. <a rel="nofollow" class="external text" href="http://genome.wellcome.ac.uk/assets/wtx030893.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">On degenerate templates and the adaptor hypothesis (PDF).</a> genome.wellcome.ac.uk (Lecture, 1955). Retrieved 22 December 2006.</span></li>
<li id="cite_note-175" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-175" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><span class="citation journal" style="word-wrap: break-word;">Meselson M, Stahl F (1958). <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528642" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">"The replication of DNA in Escherichia coli"</a>. <i>Proc Natl Acad Sci USA</i> <b>44</b> (7): 671–82. <a href="http://en.wikipedia.org/wiki/Bibcode" title="Bibcode" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Bibcode</a>:<a rel="nofollow" class="external text" href="http://adsabs.harvard.edu/abs/1958PNAS...44..671M" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">1958PNAS...44..671M</a>.<a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1073%2Fpnas.44.7.671" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1073/pnas.44.7.671</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Central" title="PubMed Central" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMC</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528642" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">528642</a>.<a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/16590258" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">16590258</a>.</span></span></li>
<li id="cite_note-176" style="margin-bottom: 0.1em;"><span class="mw-cite-backlink"><b><a href="http://en.wikipedia.org/wiki/DNA#cite_ref-176" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">^</a></b></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://nobelprize.org/nobel_prizes/medicine/laureates/1968/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">The Nobel Prize in Physiology or Medicine 1968</a>Nobelprize.org Accessed 22 December 06</span></li>
</ol>
</div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="Further_reading">Further reading</span></h2>
<div class="refbegin references-column-width" style="font-size: 11.199999809265137px; margin-bottom: 0.5em; font-family: sans-serif; line-height: 19.200000762939453px; -webkit-column-width: 30em;">
<ul style="line-height: 1.5em; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=);">
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Berry, Andrew; <a href="http://en.wikipedia.org/wiki/James_Watson" title="James Watson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Watson, James</a>. (2003). <i>DNA: the secret of life</i>. New York: Alfred A. Knopf. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-375-41546-7" title="Special:BookSources/0-375-41546-7" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-375-41546-7</a>.</span></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Calladine, Chris R.; Drew, Horace R.; Luisi, Ben F. and Travers, Andrew A. (2003). <i>Understanding DNA: the molecule & how it works</i>. Amsterdam: Elsevier Academic Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-12-155089-3" title="Special:BookSources/0-12-155089-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-12-155089-3</a>.</span></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Dennis, Carina; Julie Clayton (2003). <i>50 years of DNA</i>. Basingstoke: Palgrave Macmillan. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/1-4039-1479-6" title="Special:BookSources/1-4039-1479-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">1-4039-1479-6</a>.</span></li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Horace_Freeland_Judson" title="Horace Freeland Judson" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Judson, Horace F</a>. 1979. <i>The Eighth Day of Creation: Makers of the Revolution in Biology</i>. Touchstone Books, <a href="http://en.wikipedia.org/wiki/Special:BookSources/0671225405" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-671-22540-5</a>. 2nd edition: Cold Spring Harbor Laboratory Press, 1996 paperback: <a href="http://en.wikipedia.org/wiki/Special:BookSources/0879694785" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-87969-478-5</a>.</li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Robert_Olby" title="Robert Olby" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Olby, Robert C.</a> (1994). <i>The path to the double helix: the discovery of DNA</i>. New York: Dover Publications. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-486-68117-3" title="Special:BookSources/0-486-68117-3" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-486-68117-3</a>.</span>, first published in October 1974 by MacMillan, with foreword by Francis Crick;the definitive DNA textbook,revised in 1994 with a 9 page postscript</li>
<li style="margin-bottom: 0.1em;">Micklas, David. 2003. <i>DNA Science: A First Course</i>. Cold Spring Harbor Press: <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780879696368" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-87969-636-8</a></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Matt_Ridley" title="Matt Ridley" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Ridley, Matt</a> (2006). <i>Francis Crick: discoverer of the genetic code</i>. Ashland, OH: Eminent Lives, Atlas Books. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-06-082333-X" title="Special:BookSources/0-06-082333-X" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-06-082333-X</a>.</span></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;">Olby, Robert C. (2009). <i>Francis Crick: A Biography</i>. Plainview, N.Y: Cold Spring Harbor Laboratory Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-87969-798-9" title="Special:BookSources/0-87969-798-9" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-87969-798-9</a>.</span></li>
<li style="margin-bottom: 0.1em;">Rosenfeld, Israel. 2010. <i>DNA: A Graphic Guide to the Molecule that Shook the World</i>. Columbia University Press: <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780231142717" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-231-14271-7</a></li>
<li style="margin-bottom: 0.1em;">Schultz, Mark and Zander Cannon. 2009. <i>The Stuff of Life: A Graphic Guide to Genetics and DNA</i>. Hill and Wang: <a href="http://en.wikipedia.org/wiki/Special:BookSources/0809089475" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 0-8090-8947-5</a></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Gunther_Stent" title="Gunther Stent" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Stent, Gunther Siegmund</a>; Watson, James. (1980). <i><a href="http://en.wikipedia.org/wiki/The_Double_Helix" title="The Double Helix" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">The double helix: a personal account of the discovery of the structure of DNA</a></i>. New York: Norton. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-393-95075-1" title="Special:BookSources/0-393-95075-1" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-393-95075-1</a>.</span></li>
<li style="margin-bottom: 0.1em;">Watson, James. 2004. <i>DNA: The Secret of Life</i>. Random House: <a href="http://en.wikipedia.org/wiki/Special:BookSources/9780099451846" class="internal mw-magiclink-isbn" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN 978-0-09-945184-6</a></li>
<li style="margin-bottom: 0.1em;"><span class="citation book" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Maurice_Wilkins" title="Maurice Wilkins" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Wilkins, Maurice</a> (2003). <i>The third man of the double helix the autobiography of Maurice Wilkins</i>. Cambridge, Eng: University Press. <a href="http://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">ISBN</a> <a href="http://en.wikipedia.org/wiki/Special:BookSources/0-19-860665-6" title="Special:BookSources/0-19-860665-6" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">0-19-860665-6</a>.</span></li>
</ul>
</div>
<h2 style="background-image: none; font-weight: normal; margin: 0px 0px 0.6em; overflow: hidden; padding-top: 0.5em; padding-bottom: 0.17em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(170, 170, 170); font-size: 19.200000762939453px; font-family: sans-serif; line-height: 19.200000762939453px;"><span class="mw-headline" id="External_links">External links</span></h2>
<table class="vertical-navbox nowraplinks infobox bordered" cellspacing="5" cellpadding="0" style="border-style: solid; border-color: rgb(170, 170, 170); font-size: 11.199999809265137px; background-color: rgb(249, 249, 249); color: rgb(0, 0, 0); margin: 0px 0px 1em 1em; padding: 0.2em; float: right; clear: right; text-align: center; line-height: 1.4em; border-collapse: collapse; font-family: sans-serif; width: auto; border-spacing: 0.4em 0px;">
<tbody>
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<th style="border-style: solid; border-color: rgb(170, 170, 170); vertical-align: top; padding: 0.2em 0.4em; line-height: 1.2em; background-color: rgb(239, 239, 239); font-size: 1em;">Library resources</th>
</tr>
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<th style="border-style: solid; border-color: rgb(170, 170, 170); vertical-align: top; padding: 0.1em;">About DNA</th>
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<tr>
<td class="plainlist" style="border-style: solid; border-color: rgb(170, 170, 170); vertical-align: top; padding: 0px 0.1em 0.4em;">
<ul style="line-height: inherit; list-style: none none; margin: 0px; padding: 0px;">
<li style="margin-bottom: 0px;"><a class="external text" href="http://tools.wmflabs.org/ftl/cgi-bin/ftl?st=&su=DNA&library=OLBP" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); white-space: nowrap; padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Online books</a></li>
<li style="margin-bottom: 0px;"><a class="external text" href="http://tools.wmflabs.org/ftl/cgi-bin/ftl?st=&su=DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); white-space: nowrap; padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Resources in your library</a></li>
<li style="margin-bottom: 0px;"><a class="external text" href="http://tools.wmflabs.org/ftl/cgi-bin/ftl?st=&su=DNA&library=0CHOOSE0" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); white-space: nowrap; padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Resources in other libraries</a></li>
</ul>
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<td class="mbox-text plainlist" style="border: none; padding: 0.25em 0.9em; width: 161.3249969482422px;">Wikiquote has a collection of quotations related to: <i><b><a href="http://en.wikiquote.org/wiki/Special:Search/DNA" class="extiw" title="q:Special:Search/DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: none !important; padding: 0px !important;">DNA</a></b></i></td>
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<div style="text-align: center; white-space: nowrap;"><b>Listen to this article</b> (<a href="http://en.wikipedia.org/wiki/File:Dna.ogg" title="File:Dna.ogg" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none !important; padding: 0px !important;">info/dl</a>)
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<div style="font-size: xx-small; line-height: 1.6em; margin-left: 60px;">This audio file was created from a revision of the "<span class="fn">DNA</span>" article dated 2007-02-12, and does not reflect subsequent edits to the article. (<a href="http://en.wikipedia.org/wiki/Wikipedia:Media_help" title="Wikipedia:Media help" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none !important; padding: 0px !important;">Audio help</a>)</div>
<div style="text-align: center; clear: both;"><b><a href="http://en.wikipedia.org/wiki/Wikipedia:Spoken_articles" title="Wikipedia:Spoken articles" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none !important; padding: 0px !important;">More spoken articles</a></b></div>
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<ul style="line-height: 19.200000762939453px; margin: 0.3em 0px 0px 1.6em; padding: 0px; list-style-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAUAAAANAQMAAABb8jbLAAAABlBMVEX///8AUow5QSOjAAAAAXRSTlMAQObYZgAAABNJREFUCB1jYEABBQw/wLCAgQEAGpIDyT0IVcsAAAAASUVORK5CYII=); font-family: sans-serif; font-size: 12.800000190734863px;">
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.dmoz.org/Science/Biology/Biochemistry_and_Molecular_Biology/Biomolecules/Nucleic_Acids/DNA//" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA</a> at the <a href="http://en.wikipedia.org/wiki/Open_Directory_Project" title="Open Directory Project" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Open Directory Project</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://pipe.scs.fsu.edu/displar.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA binding site prediction on protein</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://nobelprize.org/educational_games/medicine/dna_double_helix/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA the Double Helix Game</a> From the official Nobel Prize web site</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.fidelitysystems.com/Unlinked_DNA.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA under electron microscope</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.dnalc.org/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Dolan DNA Learning Center</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nature.com/nature/dna50/archive.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Double Helix: 50 years of DNA</a>, <i><a href="http://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nature</a></i></li>
<li style="margin-bottom: 0.1em;"><i><a href="http://en.wikipedia.org/wiki/Proteopedia" title="Proteopedia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA</a></i></li>
<li style="margin-bottom: 0.1em;"><i><a href="http://en.wikipedia.org/wiki/Proteopedia" title="Proteopedia" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Proteopedia</a> <a rel="nofollow" class="external text" href="http://www.proteopedia.org/wiki/index.php/Forms_of_DNA" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Forms_of_DNA</a></i></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nature.com/encode/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">ENCODE threads explorer</a> ENCODE Home page. <a href="http://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Nature (journal)</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.ncbe.reading.ac.uk/DNA50/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Double Helix 1953–2003</a> National Centre for Biotechnology Education</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.genome.gov/10506718" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Genetic Education Modules for Teachers</a>—<i>DNA from the Beginning</i> Study Guide</li>
<li style="margin-bottom: 0.1em;"><a href="http://en.wikipedia.org/wiki/Protein_Data_Bank" title="Protein Data Bank" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PDB Molecule of the Month</a> <i><a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb23_1.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">pdb23_1</a></i></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://mason.gmu.edu/~emoody/rfranklin.html" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Rosalind Franklin's contributions to the study of DNA</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.genome.gov/10506367" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">U.S. National DNA Day</a>—watch videos and participate in real-time chat with top scientists</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nytimes.com/packages/pdf/science/dna-article.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Clue to chemistry of heredity found</a> <a href="http://en.wikipedia.org/wiki/The_New_York_Times" title="The New York Times" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">The New York Times</a> June 1953. First American newspaper coverage of the discovery of the DNA structure</li>
<li style="margin-bottom: 0.1em;"><span class="citation journal" style="word-wrap: break-word;"><a href="http://en.wikipedia.org/wiki/Robert_Olby" title="Robert Olby" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">Olby R</a> (2003). "Quiet debut for the double helix". <i>Nature</i> <b>421</b> (6921): 402–5. <a href="http://en.wikipedia.org/wiki/Digital_object_identifier" title="Digital object identifier" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">doi</a>:<a rel="nofollow" class="external text" href="http://dx.doi.org/10.1038%2Fnature01397" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">10.1038/nature01397</a>. <a href="http://en.wikipedia.org/wiki/PubMed_Identifier" title="PubMed Identifier" class="mw-redirect" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">PMID</a> <a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/pubmed/12540907" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">12540907</a>.</span></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.dnaftb.org/" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">DNA from the Beginning</a> Another DNA Learning Center site on DNA, genes, and heredity from Mendel to the human genome project.</li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://orpheus.ucsd.edu/speccoll/testing/html/mss0660a.html#abstract" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">The Register of Francis Crick Personal Papers 1938 – 2007</a> at Mandeville Special Collections Library, <a href="http://en.wikipedia.org/wiki/University_of_California,_San_Diego" title="University of California, San Diego" style="text-decoration: none; color: rgb(11, 0, 128); background-image: none;">University of California, San Diego</a></li>
<li style="margin-bottom: 0.1em;"><a rel="nofollow" class="external text" href="http://www.nature.com/polopoly_fs/7.9746!/file/Crick%20letter%20to%20Michael.pdf" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(http://upload.wikimedia.org/wikipedia/commons/2/23/Icons-mini-file_acrobat.gif); padding-right: 18px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Seven-page, handwritten letter that Crick sent to his 12-year-old son Michael in 1953 describing the structure of DNA.</a> See <a rel="nofollow" class="external text" href="http://www.nature.com/news/crick-s-medal-goes-under-the-hammer-1.12705" style="text-decoration: none; color: rgb(102, 51, 102); background-image: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAKCAYAAACNMs+9AAAAVklEQVR4Xn3PgQkAMQhDUXfqTu7kTtkpd5RA8AInfArtQ2iRXFWT2QedAfttj2FsPIOE1eCOlEuoWWjgzYaB/IkeGOrxXhqB+uA9Bfcm0lAZuh+YIeAD+cAqSz4kCMUAAAAASUVORK5CYII=); padding-right: 13px; background-position: 100% 50%; background-repeat: no-repeat no-repeat;">Crick’s medal goes under the hammer</a>, Nature, 5 April 2013.</li>
</ul>
