=== <span style="font -size="4:16px;">A highly annotated whole-genome sequence of a Korean individual</font><br /span>===<br />Nature Letter.<br /><br />8th July 2009<br /><br /span style="font-size:16px;">Recent advances in sequencing technologies have initiated an era of personal genome sequences. To date, human genome sequences have been reported for individuals with ancestry in three distinct geographical regions: a Yoruba African, two individuals of northwest European origin, and a person from China^{<a href="[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08211.html#B1"><font color="#000080">1, </font></a>]}^{<a href="[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08211.html#B2"><font color="#000080">2, </font></a>]}^{<a href="[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08211.html#B3"><font color="#000080">3, </font></a>]}^{<a href="[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08211.html#B4"><font color="#000080">4</font></a>]}. Here we provide a highly annotated, whole-genome sequence for a Korean individual, known as AK1. The genome of AK1 was determined by an exacting, combined approach that included whole-genome shotgun sequencing (27.8<img style="BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; VERTICAL-ALIGN: middle; BORDER-TOP: 0px; BORDER-RIGHT: 0px" alt="times" src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> coverage), targeted bacterial artificial chromosome sequencing, and high-resolution comparative genomic hybridization using custom microarrays featuring more than 24&nbsp;million probes. Alignment to the NCBI reference, a composite of several ethnic clades^{<a href="[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08211.html#B5"><font color="#000080">5, </font></a>]}^{<a href="[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08211.html#B6"><font color="#000080">6</font></a>]}, disclosed nearly 3.45&nbsp;million single nucleotide polymorphisms (SNPs), including 10,162 non-synonymous SNPs, and 170,202 deletion or insertion polymorphisms (indels). SNP and indel densities were strongly correlated genome-wide. Applying very conservative criteria yielded highly reliable copy number variants for clinical considerations. Potential medical phenotypes were annotated for non-synonymous SNPs, coding domain indels, and structural variants. The integration of several human whole-genome sequences derived from several ethnic groups will assist in understanding genetic ancestry, migration patterns and population bottlenecks.<br /><br /><a href="[http://wwwkogic.naturenet/index.com/nature/journal/vaop/ncurrent/php?title=The_second_Korean_human_genome&action=edit Link to fullarticle]<br/nature08211.html">http:<br//www> Nature.nature&nbsp;2009.com/nature/journal/vaop/ncurrent/full/nature0821107.html08</aspan><br />&nbsp;<br /><font size="4">=== See also<br />==== </span style="font-size:16px;">[[The_first_Korean_human_genome|The first Korean human genome]]</span><br />[[A_korean_genome_sequence_is_announced_to_the_public_using_a_Solexa_sequencer_2008_12_04|<span style="font-size:16px;">A korean genome sequence is announced to the public using a Solexa sequencer 2008 12 04</span>]]<br/> <br/> &nbsp;