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<div class="contrib-group fm-author"><span style="font-size: x-small">David R. Bentley,^{<font size="2">1</font>} Shankar Balasubramanian,<font size="2">^2*Harold P. Swerdlow,^*1&dagger;</font> Harold Geoffrey P. SwerdlowSmith,<font size="2">¹John Milton,^{1&daggersect;}Clive G. Brown,^{1&sect;</fontsup> Geoffrey Kevin P. SmithHall,^{<font size="2">1</font>} John MiltonDirk J. Evers,<font size="2">¹Colin L. Barnes,^&sect;1,2</font> Clive GHelen R. BrownBignell,<font size="2">¹Jonathan M. Boutell,^&sect;1Jason Bryant,^{1</fontsup> Kevin PRichard J. HallCarter,^{1<font size="2"/sup>1R. Keira Cheetham,</fontsup>1} Dirk Anthony J. EversCox,^{<font size="2">1</font>} Colin LDarren J. BarnesEllis,<font size="2">^1,Michael R. Flatbush,²³</font> Helen RNiall A. BignellGormley,^{<font size="2">1</font>} Jonathan MSean J. BoutellHumphray,^{<font size="2">1</font>} Jason BryantLeslie J. Irving,^{<font size="2">1</font>} Richard JMirian S. CarterKarbelashvili,^{<font size="2">1</font>3} RScott M. Keira CheethamKirk,^{3<font size="2"/sup>1Heng Li,</fontsup>4} Anthony J. CoxXiaohai Liu,^{1,2<font size="2"/sup>1Klaus S. Maisinger,</fontsup>1} Darren Lisa J. EllisMurray,^{<font size="2">1</font>} Michael R. FlatbushBojan Obradovic,^{1<font size="2"/sup>3Tobias Ost,</fontsup>1} Niall AMichael L. GormleyParkinson,^{<font size="2">1</fontsup>Mark R. Pratt,³ Sean Isabelle M. J. HumphrayRasolonjatovo,^{1<font size="2"/sup>1Mark T. Reed,</fontsup>3} Leslie J. IrvingRoberto Rigatti,^{1<font size="2"/sup>1Chiara Rodighiero,</fontsup>1} Mirian SMark T. KarbelashviliRoss,^{1<font size="2"/sup>3Andrea Sabot,</fontsup>1} Scott MSubramanian V. KirkSankar,^{<font size="2">3</font>} Heng LiAylwyn Scally,^{4<font size="2"/sup>4Gary P. Schroth,</fontsup>3} Xiaohai LiuMark E. Smith,<font size="2"sup>1}1Vincent P. Smith,}1}2Anastassia Spiridou,</sup>1</fontsup> Klaus SPeta E. MaisingerTorrance,^{1<font size="2"/sup>1Svilen S. Tzonev,</fontsup>3} Lisa JEric H. MurrayVermaas,^{3<font size="2"/sup>1Klaudia Walter,</fontsup>4} Bojan ObradovicXiaolin Wu,^{<font size="2">1</font>} Tobias OstLu Zhang,^{<font size="2">1</font>3} Michael LMohammed D. ParkinsonAlam,^{3<font size="2"/sup>1Carole Anastasi,</fontsup>1} Mark RIfy C. PrattAniebo,^{<font size="2">3</font>1} Isabelle David M. JD. RasolonjatovoBailey,^{<font size="2">1</font>} Mark TIain R. ReedBancarz,^{<font size="2">3</font>1} Roberto RigattiSaibal Banerjee,<sup>3<font size="2">1</font><//sup> Chiara RodighieroSelena G. Barbour,^{<font size="2">1</font>} Mark TPrimo A. RossBaybayan,^{3<font size="2"/sup>1Vincent A. Benoit,</fontsup>1} Andrea SabotKevin F. Benson,^{1<font size="2"/sup>1Claire Bevis,</fontsup>1} Subramanian VPhillip J. SankarBlack,^{1<font size="2"/sup>3Asha Boodhun,</fontsup>1} Aylwyn ScallyJoe S. Brennan,<sup>1<font size="2"/sup>4</fontJohn A. Bridgham,³ Gary PRob C. SchrothBrown,^{<font size="2">3</font>1} Mark EAndrew A. SmithBrown,^{1<font size="2"/sup>1Dale H. Buermann,</fontsup>3} Vincent PAbass A. SmithBundu,^{<font size="2">1</font>} Anastassia SpiridouJames C. Burrows,<sup>3<font size="2"/sup> Nigel P. Carter,<sup>14</fontsup> Nestor Castillo,³ Peta Maria Chiara E. TorranceCatenazzi,<sup><font size="2">1</fontsup> Simon Chang,³ Svilen SR. TzonevNeil Cooley,^{1<font size="2"/sup>3Natasha R. Crake,</fontsup>1} Eric HOlubunmi O. VermaasDada,^{1<font size="2"/sup>3Konstantinos D. Diakoumakos,</fontsup>1} Klaudia WalterBelen Dominguez-Fernandez,^{<font size="2">4</font>1} Xiaolin WuDavid J. Earnshaw,^{1,2<font size="2"/sup>1Ugonna C. Egbujor,</fontsup>1} Lu ZhangDavid W. Elmore,^{<font size="2">3</fontsup> Sergey S. Etchin,³ Mohammed DMark R. AlamEwan,^{3<font size="2"/sup>3Milan Fedurco,</fontsup>5} Carole AnastasiLouise J. Fraser,^{<font size="2">1</font>} Ify CKarin V. AnieboFuentes Fajardo,^{<font size="2">1</font>} David MW. D. BaileyScott Furey,^{2<font size="2"/sup>1David George,</fontsup>3} Iain RKimberley J. BancarzGietzen,^{<font size="2">16</fontsup>Colin P. Goddard,} Saibal Banerjee,1}George S. Golda,<font size="2"sup>3</fontsup> Philip A. Granieri,³ Selena GDavid E. BarbourGreen,^{1<font size="2">1/sup> David L. Gustafson,</fontsup>3} Primo ANancy F. BaybayanHansen,^{7<font size="2"/sup>3Kevin Harnish,</fontsup>1} Vincent AChristian D. BenoitHaudenschild,^{3<font size="2"/sup>1Narinder I. Heyer,</fontsup>1} Kevin FMatthew M. BensonHims,<sup><font size="2">1</fontsup>Johnny T. Ho,³ Claire BevisAdrian M. Horgan,^{1<font size="2"/sup>1Katya Hoschler,</fontsup>1} Phillip J. BlackSteve Hurwitz,^{3<font size="2"/sup>1Denis V. Ivanov,</fontsup>3} Asha BoodhunMaria Q. Johnson,^{3<font size="2"/sup>1Terena James,</fontsup>1} Joe ST. A. BrennanHuw Jones,^{1<font size="2"/sup>1Gyoung-Dong Kang,</fontsup>1} John ATzvetana H. BridghamKerelska,^{<font size="2">3</font>} Rob CAlan D. BrownKersey,^{1<font size="2"/sup>1Irina Khrebtukova,</fontsup>3} Andrew AAlex P. BrownKindwall,<sup>3<font size="2"/sup> Zoya Kingsbury,^1</font> Dale HPaula I. BuermannKokko-Gonzales,^{1<font size="2"/sup>3Anil Kumar,</fontsup>1} Abass Marc A. BunduLaurent,^{6<font size="2"/sup>1Cynthia T. Lawley,</fontsup>6} James CSarah E. BurrowsLee,^{<font size="2">3</font>1} Nigel P. CarterXavier Lee,^{3<font size="2"/sup>4Arnold K. Liao,</fontsup>3} Nestor CastilloJennifer A. Loch,^{1<font size="2"/sup> Mitch Lok,^{3</fontsup> Shujun Luo,³ Maria Chiara ERadhika M. CatenazziMammen,^{<font size="2">1</font>} Simon ChangJohn W. Martin,^{<font size="2">3</font>} RPatrick G. Neil CooleyMcCauley,^{<font size="2">1</font>} Natasha R. CrakePaul McNitt,^{3<font size="2"/sup>1Parul Mehta,</fontsup>1} Olubunmi OKeith W. DadaMoon,^{<font size="2">1</font>3} Konstantinos DJoe W. DiakoumakosMullens,^{3<font size="2"/sup>1Taksina Newington,</fontsup>1} Belen Dominguez-FernandezZemin Ning,^{4<font size="2"/sup>1Bee Ling Ng,</fontsup>4} David JSonia M. EarnshawNovo,<font size="2">^1,Michael J. O'Neill,²³</font> Ugonna CMark A. EgbujorOsborne,^{1,2<font size="2"/sup>1Andrew Osnowski,</fontsup>1} David W. ElmoreOmead Ostadan,^{<font size="2">3</font>,6} Sergey SLambros L. EtchinParaschos,^{3<font size="2"/sup>3Lea Pickering,</fontsup>1} Mark RAndrew C. EwanPike,^{<font size="2">31</fontsup>Alger C. Pike,} Milan Fedurco3} D. Chris Pinkard,^{3<font size="2"/sup>5Daniel P. Pliskin,</fontsup>3} Louise J. FraserJoe Podhasky,^{3<font size="2"/sup>1Victor J. Quijano,</fontsup>3} Karin V. Fuentes FajardoCome Raczy,^{<font size="2">1</font>} WVicki H. Scott FureyRae,^{1<font size="2"/sup>2Stephen R. Rawlings,</fontsup>1} David GeorgeAna Chiva Rodriguez,^{<font size="2">3</font>1} Kimberley JPhyllida M. GietzenRoe,^{1<font size="2"/sup>6John Rogers,</fontsup>1} Colin PMaria C. GoddardRogert Bacigalupo,^{<font size="2">1</font>} George S. GoldaNikolai Romanov,^{1<font size="2"/sup>3Anthony Romieu,</fontsup>5} Philip ARithy K. GranieriRoth,^{<font size="2">3</fontsup>Natalie J. Rourke,¹ David ESilke T. GreenRuediger,^{1<font size="2"/sup>1Eli Rusman,</fontsup>3} David LRaquel M. GustafsonSanches-Kuiper,^{<font size="2">3</font>1} Nancy FMartin R. HansenSchenker,^{<font size="2">7</font>1} Kevin HarnishJosefina M. Seoane,^{3<font size="2"/sup>1Richard J. Shaw,</fontsup>1} Christian DMitch K. HaudenschildShiver,^{<font size="2">3</fontsup>Steven W. Short,} Narinder I3} Ning L. HeyerSizto,^{3<font size="2"/sup>1Johannes P. Sluis,</fontsup>3} Matthew MMelanie A. HimsSmith,^{1<font size="2"/sup>1Jean Ernest Sohna Sohna,</fontsup>1} Johnny TEric J. HoSpence,^{<font size="2">3</font>} Adrian M. HorganKim Stevens,^{1<font size="2"/sup>1Neil Sutton,</fontsup>1} Katya HoschlerLukasz Szajkowski,^{<font size="2">1</font>} Steve HurwitzCarolyn L. Tregidgo,^{1<font size="2"/sup>3Gerardo Turcatti,</fontsup>5} Denis V. IvanovStephanie vandeVondele,^{1<font size="2"/sup>3Yuli Verhovsky,</fontsup>3} Maria QSelene M. JohnsonVirk,^{<font size="2">3</font>} Terena JamesSuzanne Wakelin,^{3<font size="2"/sup>1Gregory C. Walcott,</fontsup>3} T. A. Huw JonesJingwen Wang,¹ Graham J. Worsley,<font size="2"sup>1</fontsup> Juying Yan,³ Gyoung-Dong KangLing Yau,^{<font size="2">1</font>3} Tzvetana H. KerelskaMike Zuerlein,^{<font size="2">3</font>} Alan D. KerseyJane Rogers,^{4<font size="2"/sup>1James C. Mullikin,</fontsup>7} Irina KhrebtukovaMatthew E. Hurles,^{<font size="2">34</fontsup>Nick J. McCooke,} Alex P1&Dagger;} John S. KindwallWest,^{3<font size="2"/sup>3Frank L. Oaks,</fontsup>3} Zoya KingsburyPeter L. Lundberg,^{<font size="2">1</font>3} Paula I. Kokko-GonzalesDavid Klenerman,^{<font size="2">1</font>*} Anil KumarRichard Durbin,^{4<font size="2">1</font>} Marc A. Laurent,^{<font size="2">6</font>} Cynthia T. Lawley,^{<font size="2">6</font>} Sarah E. Lee,^{<font size="2">1</font>} Xavier Lee,^{<font size="2">3</font>} Arnold K. Liao,^{<font size="2">3</font>} Jennifer A. Loch,^{<font size="2">1</font>} Mitch Lok,^{<font size="2">3</font>} Shujun Luo,^{<font size="2">3</font>} Radhika M. Mammen,^{<font size="2">1</font>} John W. Martin,^{<font size="2">3</font>} Patrick G. McCauley,^{<font size="2">1</font>} Paul McNitt,^{<font size="2">3</font>} Parul Mehta,^{<font size="2">1</font>} Keith W. Moon,^{<font size="2">3</font>} Joe W. Mullens,^{<font size="2">3</font>} Taksina Newington,^{<font size="2">1</font>} Zemin Ning,^{<font size="2">4</font>} Bee Ling Ng,^{<font size="2">4</font>} Sonia M. Novo,^{<font size="2">1</font>} Michael J. O'Neill,^{<font size="2">3</font>} Mark A. Osborne,<font size="2">^1,²</font> Andrew Osnowski,^{<font size="2">1</font>} Omead Ostadan,<font size="2">^3,⁶</font> Lambros L. Paraschos,^{<font size="2">3</font>} Lea Pickering,^{<font size="2">1</font>} Andrew C. Pike,^{<font size="2">1</font>} Alger C. Pike,^{<font size="2">3</font>} D. Chris Pinkard,^{<font size="2">3</font>} Daniel P. Pliskin,^{<font size="2">3</font>} Joe Podhasky,^{<font size="2">3</font>} Victor J. Quijano,^{<font size="2">3</font>} Come Raczy,^{<font size="2">1</font>} Vicki H. Rae,^{<font size="2">1</font>} Stephen R. Rawlings,^{<font size="2">1</font>} Ana Chiva Rodriguez,^{<font size="2">1</font>} Phyllida M. Roe,^{<font size="2">1</font>} John Rogers,^{<font size="2">1</font>} Maria C. Rogert Bacigalupo,^{<font size="2">1</font>} Nikolai Romanov,^{<font size="2">1</font>} Anthony Romieu,^{<font size="2">5</font>} Rithy K. Roth,^{<font size="2">3</font>} Natalie J. Rourke,^{<font size="2">1</font>} Silke T. Ruediger,^{<font size="2">1</font>} Eli Rusman,^{<font size="2">3</font>} Raquel M. Sanches-Kuiper,^{<font size="2">1</font>} Martin R. Schenker,^{<font size="2">1</font>} Josefina M. Seoane,^{<font size="2">3</font>} Richard J. Shaw,^{<font size="2">1</font>} Mitch K. Shiver,^{<font size="2">3</font>} Steven W. Short,^{<font size="2">3</font>} Ning L. Sizto,^{<font size="2">3</font>} Johannes P. Sluis,^{<font size="2">3</font>} Melanie A. Smith,^{<font size="2">1</font>} Jean Ernest Sohna Sohna,^{<font size="2">1</font>} Eric J. Spence,^{<font size="2">3</font>} Kim Stevens,^{<font size="2">1</font>} Neil Sutton,^{<font size="2">1</font>} Lukasz Szajkowski,^{<font size="2">1</font>} Carolyn L. Tregidgo,^{<font size="2">1</font>} Gerardo Turcatti,^{<font size="2">5</font>} Stephanie vandeVondele,^{<font size="2">1</font>} Yuli Verhovsky,^{<font size="2">3</font>} Selene M. Virk,^{<font size="2">3</font>} Suzanne Wakelin,^{<font size="2">3</font>} Gregory C. Walcott,^{<font size="2">3</font>} Jingwen Wang,^{<font size="2">1</font>} Graham J. Worsley,^{<font size="2">1</font>} Juying Yan,^{<font size="2">3</font>} Ling Yau,^{<font size="2">3</font>} Mike Zuerlein,^{<font size="2">3</font>} Jane Rogers,^{<font size="2">4</font>} James C. Mullikin,^{<font size="2">7</font>} Matthew E. Hurles,^{<font size="2">4</font>} Nick J. McCooke,<font size="2">¹^&Dagger;</font> John S. West,^{<font size="2">3</font>} Frank L. Oaks,^{<font size="2">3</font>} Peter L. Lundberg,^{<font size="2">3</font>} David Klenerman,<font size="2">²^*</font> Richard Durbin,<sup><font size="2">4</font><//sup> and Anthony J. Smith<sup><font size="2">1</fontsup></supspan></div>

<div class="fm-affl">^{<font size="2">1</font>}<span style="font-size: small">Illumina Cambridge Ltd., (Formerly Solexa Ltd) Chesterford Research Park, Little Chesterford, Nr Saffron Walden, Essex. CB10 1XL, UK</span></div><div class="fm-affl">^{<span style="font -size="2: small">2</fontsup>2}Department of Chemistry, University of Cambridge, The University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK</span></div><div class="fm-affl">^{<span style="font -size="2: small">3</fontsup>3}Illumina Hayward, (Formerly Solexa Inc) 23851 Industrial Bvld, Hayward, CA 94343, USA</span></div><div class="fm-affl">^{<span style="font -size="2: small">4</fontsup>4}The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK</span></div><div class="fm-affl">^{<span style="font -size="2: small">5</fontsup>5}Manteia Predictive Medicine S.A. Zone Industrielle, Coinsins, CH-1267, Switzerland</span></div><div class="fm-affl">^{<span style="font -size="2: small">6</fontsup>6}Illumina Inc. ,Corporate Headquarters, 9883 Towne Centre Drive, San Diego, CA 92121, USA</span></div><div class="fm-affl">^{<span style="font -size="2: small">7</fontsup>7}National Human Genome Research Institute, National Institutes of Health, 41 Center Drive, MSC 2132, 9000 Rockville Pike, Bethesda, MD 20892-2132, USA</span></div><div id="FN1" class="fm-footnote">^{<span style="font -size="2: small">*</fontsup>*}Inventors and founders of Solexa Ltd</span></div><div id="FN2" class="fm-footnote"><sup><span style="font -size="2: small">^{&dagger;</font>}The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK</span></div><div id="FN3" class="fm-footnote"><sup><span style="font -size="2: small">^{&sect;</font>}Oxford Nanopore Technologies, Begbroke Science Park, Sandy Lane, Kidlington. OX5 1PF</span></div><div id="FN4" class="fm-footnote"><sup><span style="font -size="2: small">^{&Dagger;</font>}Pronota, NV, VIB Bio-Incubator, Technologiepark 4, B-9052 Zwijnaarde / Ghent, Belgium</span></div><div id="cor1" class="fm-footnote"><span style="font-size: small">Correspondence and requests for materials should be addressed to David.R. Bentley (<span class="email-label">Email: </span></span><span class="e_id4842102"><a class="ext-reflink" href="mailto:dbentley@illumina.com"><span style="font-size: small">dbentley@illumina.com</span></a></span><span style="font-size: small"> <script language="JavaScript" type="text/javascript"><!--

//--></script>)</span></div><p><span style="font-size: small">&nbsp;</span></p>